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Mimics research v 21

Manufactured by Materialise
Sourced in Belgium

Mimics (Research v 21.0) is a software application developed by Materialise. It is designed for the analysis and visualization of medical image data, such as those obtained from CT or MRI scans. The core function of Mimics (Research v 21.0) is to process and manipulate this image data, allowing users to create 3D models and perform various analyses.

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2 protocols using mimics research v 21

1

Detailed Craniofacial Reconstruction Modeling

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The digital model process illustrated in Figure 1A began with a preoperation spiral CT scan (Siemens Somatom Definition Flash). DICOM (Digital Imaging and Communications in Medicine) images from the scanner were imported into Mimics (Research v 21.0, Materialise, Leuven, Belgium) for segmentation of the skull. A mask created using the “Bone CT” threshold (226-3071 HU) was used to isolate the bone material from the surrounding soft tissue based on variations in Hounsfield units. The mask was manually edited to remove artifacts. A 3D object of the bone mask was generated and exported as a standard tessellation (STL) file. This STL file was imported into Geomagic (2014, 3D Systems, Rock Hill, S.C.), in which a smoothing operation was performed. A coordinate system was manually established and defined using the X-Y-Z axes as shown in Figure 1B. This also established the medial, sagittal, and coronal planes. The anterior (A)-posterior (P) axis was defined as the x-axis, the superior (S)-inferior (I) axis was defined as the y-axis, and the lateral (L)-medial (M) axis was defined as the z-axis.
The intact nontrauma side was isolated and a mirror function across the mid-sagittal plane was performed. The skull model was further isolated approximately 30 mm superiorly of the orbit, inferiorly to include a portion of the upper dentition, and posteriorly to include the full zygomatic arch.
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2

Multimodal Imaging of Device Structures

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Optical images of the various devices were taken using a SZ16 Stereomicroscope (Olympus) equipped with an Infinity 2 CCD camera (Lumenera). Computer tomography (CT) scans were obtained on a MicroCT 35, ScanCo Medical, Brüttisellen, Switzerland. The following conditions were used: X-ray tube potential 70 kVp, integration time 300 ms, X-ray intensity 145 μA, isotropic voxel size 12 um, frame averaging 1, projections 500, medium resolution scan. CT scans were converted to DIACOM format and segmented in Mimics Research V21.0 (Materialise). Scanning electron micrographs were acquired on a FEI Inspect F using a10 kV applied voltage, spot size of 1.0, working distance of 10.5 mm, and a dwell time of 3 μs.
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