Fdl169

Manufactured by Selleck Chemicals

The FDL169 is a laboratory instrument designed for performing fluorescence detection and analysis. It is capable of measuring the fluorescence intensity of samples, which can be useful in various scientific applications.

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Lab products found in correlation

Vx 809, by Selleck Chemicals (3 mentions) Vx 661, by Selleck Chemicals (2 mentions) Vx 770, by Selleck Chemicals (2 mentions) Wheat germ agglutinin (wga), by Thermo Fisher Scientific (1 mentions) Forskolin, by Merck Group (1 mentions) Na k atpase ab76020, by Abcam (1 mentions)

3 protocols using fdl169

Characterization of CFTR Modulators

Cited 1 time

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CFTR modulators VX-770, VX-661, VX-809, and FDL169 were purchased from Selleckchem. Correctors 4172, 3151 from Life Chemicals, and 6258 from Maybridge have been described before (21 (link)). VX-445 EN1 and EN2 were purchased from MedChemExpress, with an enantiomeric excess of 92% and 75.6% as determined by chiral liquid chromatography. ABBV-2222 and VX-445 were synthesized as described below. The combination of VX-661 (lumacaftor), VX-445 (elexacaftor), and VX-770 (ivacaftor) is sold by Vertex Pharmaceuticals under the trade name Trikafta.

Veit G., Roldan A., Hancock M.A., Da Fonte D.F., Xu H., Hussein M., Frenkiel S., Matouk E., Velkov T, & Lukacs G.L. (2020). Allosteric folding correction of F508del and rare CFTR mutants by elexacaftor-tezacaftor-ivacaftor (Trikafta) combination. JCI Insight, 5(18), e139983.

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CFTR Modulators Potentiation and Correction

Cited 2 times

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CFTR modulators VX-770, VX-661, VX-809, FDL169 were purchased from Selleckchem. VX-445 and ABBV-2222 were synthesized as described before [27 (link)]. 4172 and 3151 were acquired from Life Chemicals and their function as CFTR correctors has been described [19 (link)].

Veit G., Velkov T., Xu H., Vadeboncoeur N., Bilodeau L., Matouk E, & Lukacs G.L. (2021). A Precision Medicine Approach to Optimize Modulator Therapy for Rare CFTR Folding Mutants. Journal of Personalized Medicine, 11(7), 643.

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Forskolin and CFTR Modulator Study

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Forskolin (#11018) was purchased from Sigma-Aldrich (St Louis, MO); VX-809 (#S1565) and FDL169 (#S8795) were purchased from Selleck Chemicals (Houston, TX); HSP27 (SC13132), HSP70 (SC66048) antibodies were purchased from Santa Cruz Biotechnology (Dallas, TX); Sox9 (ab185230) and Na⁺/K⁺ ATPase (#ab76020) antibodies were purchased from Abcam (Cambridge, United Kingdom); WGA (#W11261) was purchased from Invitrogen (Waltham, MA); and HSP90 (ADI-SPA-830F) antibody was purchased from Enzo Life Sciences (Farmingdale, NY).

Yanda M.K., Tomar V, & Cebotaru L. (2021). Therapeutic Potential for CFTR Correctors in Autosomal Recessive Polycystic Kidney Disease. Cellular and Molecular Gastroenterology and Hepatology, 12(5), 1517-1529.

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