R1881

Manufactured by DuPont

R1881 is a synthetic androgen receptor agonist commonly used in research applications. It is a widely recognized and well-characterized chemical compound. The core function of R1881 is to selectively activate and bind to the androgen receptor, making it a valuable tool for studying androgen receptor signaling and related biological processes.

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Lab products found in correlation

Nile red, by Merck Group (1 mentions) Dihydrotestosterone dht, by Merck Group (1 mentions) Metformin 1 1 dimethylbiguanide hydrochloride, by Merck Group (1 mentions) Palmitate, by Merck Group (1 mentions)

Spelling variants of this product

Methyltrienolone (R1881) (2 citations)

2 protocols using r1881

Preparation of Lipid Modulators for Cellular Assays

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Triclosan [5-chloro-2-(2,4-dichlorophenoxy)phenol] (1) (Merck Calbiochem), methyl triclosan [5-chloro-2-(24-dichlorophenoxy)anisole] (2) (Sigma), C75 [(2R*,3S*)-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic acid] (Sigma, Tocris Bioscience), orlistat [N-formyl-L-leucine (1S)-1-[[2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester] (Sigma), AICAR [5-amino-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide] (Sigma), TOFA [5-(Tetradecyloxy)-2-furoic acid] (Sigma) were dissolved in DMSO, metformin [1,1-dimethylbiguanide hydrochloride] (Sigma) was dissolved in phosphate-buffered saline (PBS), Nile Red (Sigma) was dissolved in acetone and diluted in PBS, the androgens dihydrotestosterone (DHT) (Sigma), mibolerone (a kind gift from Dr. L. Butler) and R1881 (Dupont) as well as palmitate (Sigma) were dissolved in 95% ethanol (EtOH) and diluted in 20% ethanol.

Sadowski M.C., Pouwer R.H., Gunter J.H., Lubik A.A., Quinn R.J, & Nelson C.C. (2014). The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancer. Oncotarget, 5(19), 9362-9381.

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R1881 Cell Receptor Activation

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R1881 was purchased from DuPont (Boston, MA). Antibodies that were used are listed below. siGenome On Target Plus SmartPools were purchased from Thermo-Scientific (Lafayette, CO).

Liu S., Kumari S., Hu Q., Senapati D., Venkadakrishnan V.B., Wang D., DePriest A.D., Schlanger S.E., Ben-Salem S., Valenzuela M.M., Willard B., Mudambi S., Swetzig W.M., Das G.M., Shourideh M., Koochekpour S., Falzarano S.M., Magi-Galluzzi C., Yadav N., Chen X., Lao C., Wang J., Billaud J.N, & Heemers H.V. (2017). A comprehensive analysis of coregulator recruitment, androgen receptor function and gene expression in prostate cancer. eLife, 6, e28482.

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