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Acrylfentanyl

Manufactured by Cayman Chemical
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Sourced in United States

Acrylfentanyl is a synthetic opioid that is used in research and development. It is a chemical compound that can be used in the analysis and evaluation of various substances. The core function of Acrylfentanyl is to serve as a research tool for the study and understanding of opioid-related compounds and their effects.

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Lab products found in correlation

Acetyl fentanyl, by Cayman Chemical (4 mentions) Furanyl fentanyl, by Cayman Chemical (3 mentions) 4 anpp, by Cayman Chemical (2 mentions) Methanol, by Merck Group (2 mentions) Ammonium formate, by Merck Group (2 mentions) Methoxyacetylfentanyl, by Cayman Chemical (2 mentions) Valeryl fentanyl, by Cayman Chemical (2 mentions) Acetic acid, by Merck Group (2 mentions) Alfentanil, by Cayman Chemical (1 mentions) Morphine, by Cayman Chemical (1 mentions) Para fluorofentanyl, by Cayman Chemical (1 mentions) Despropionylpara fluorofentanyl, by Cayman Chemical (1 mentions) Fentanyl d5, by Cayman Chemical (1 mentions) Acetonitrile, by Merck Group (1 mentions) Sodium bicarbonate, by Merck Group (1 mentions) Sodium carbonate, by Merck Group (1 mentions) 2 propanol, by Merck Group (1 mentions) Procaine, by Merck Group (1 mentions) Methanol, by Cerilliant (1 mentions) Butyryl fentanyl, by Cayman Chemical (1 mentions)

4 protocols using acrylfentanyl

1

Quantitative Analysis of Synthetic Opioids

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Standard of acetylfentanyl (hydrochloride), acrylfentanyl (hydrochloride), alfentanil (hydrochloride), butyrylfentanyl, carfentanyl, (±)-cis-3-methylfentanyl (hydrochloride), (±)-cis-3-methylthiofentanyl (hydrochloride), fentanyl (hydrochloride), furanylfentanyl (hydrochloride), α-methylfentanyl (hydrochloride), α-methylthiofentanyl (hydrochloride), β-hydroxyfentanyl (hydrochloride), ortho-fluorofentanyl (hydrochloride), ocfentanyl, para-fluorofentanyl (hydrochloride), remifentanyl (hydrochloride), sufentanyl, 4-ANPP, norfentanyl, butyrylfentanyl carboxy metabolite, despropionylpara-fluorofentanyl, (±)-trans-3-methyl norfentanyl, methoxyacetyl norfentanyl (hydrochloride), valerylfentanyl carboxy metabolite, morphine, methadone, EDDP, 6-MAM, codeine, MT-45, fentanyl-d5 (hydrochloride) and nordentanyl-d5 were purchased from Cayman Chemical (Ann Arbor, MI, USA) in form of methanolic solution at the concentration of 1 mg mL−1. Working solutions were prepared at the concentration of 1 μg mL−1 and stored at −20 °C. Water, methanol, acetonitrile and 2-propanol were obtained from Carlo Erba (Milano, Italia) while sodium carbonate, sodium bicarbonate and ammonium formate were purchased from Sigma-Aldrich (Milwaukee, WI, USA).
Vincenti F., Montesano C., Pirau S., Gregori A., Di Rosa F., Curini R, & Sergi M. (2021). Simultaneous Quantification of 25 Fentanyl Derivatives and Metabolites in Oral Fluid by Means of Microextraction on Packed Sorbent and LC–HRMS/MS Analysis. Molecules, 26(19), 5870.
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2

Opioid and Synthetic Opioid Separations

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The run buffer used for opioid and synthetic opioid separations was 12 mmol/L acetic acid, 3.3 mmol/L ammonium acetate pH 4.4 (Sigma-Aldrich, St. Louis, MO, USA) in ultrapure water (Millipore Milli-Q, 18.0 MΩ-cm). Acetaminophen, caffeine, mannitol, procaine, quinine, and methanol were all purchased from Sigma-Aldrich (St. Louis, MO, USA).
All fentanyl analogues (acetyl fentanyl, acryl fentanyl, benzyl fentanyl, butyryl fentanyl, furanyl fentanyl, methacryl fentanyl, methoxyacetyl fentanyl, phenyl fentanyl, valeryl fentanyl) were purchased as hydrochloride salts from Cayman Chemical (Ann Arbor, MI, USA) or, when possible, as 1 mg·mL−1 methanolic solutions. Powdered standards and samples were dissolved gravimetrically in methanol (Sigma-Aldrich, St. Louis, MO). The remaining opioids and narcotics (heroin, fentanyl, cocaine, U-47700) were purchased as 1 mg·mL−1 solutions in methanol or acetonitrile from Cerilliant (Round Rock, TX, USA). All sample dilutions were prepared in run buffer, and methanol was added as necessary to allow for a constant 4 % by volume organic solvent across all analyses. When increased analyte concentrations were desired, standards were concentrated to assure each sample contained a maximum of 4 % (v/v) solvent.
Krauss S.T., Ross D, & Forbes T.P. (2019). Separation and detection of trace fentanyl from complex mixtures using gradient elution moving boundary electrophoresis.. Analytical chemistry, 91(20), 13014-13021.
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3

Quantification of Novel Fentanyl Analogs

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Acetylfentanyl, acrylfentanyl, furanylfentanyl and 4-fluoro-isobutyrylfentanyl were purchased as powders from Cayman Chemical (Ann Arbor, USA), diclofenac from Sigma (Stockholm, Sweden). Cryopreserved hepatocytes LiverPool (10-donor-pool), InVitro Gro HT and InVitro Gro KHB media were obtained from Bioreclamation IVT (Brussels, Belgium). Liquid chromatography mass spectrometry grade acetonitrile, water, methanol and formic acid were from Fisher Scientific (Gothenburg, Sweden), ammonium formate from Fluka (Sigma-Aldrich, Stockholm, Sweden), ammonium acetate and acetic acid from Merck (Darmstadt, Germany). The βglucuronidase/sulfatase mixture (Helix pomatia) was purchased from Roche (Mannheim, Germany). Ultra-pure water was prepared in-house using a MilliQ Gradient 10 production unit (Millipore, Billerica, USA).
Watanabe S., Vikingsson S., Roman M., Green H., Kronstrand R, & Wohlfarth A. (2017). In Vitro and In Vivo Metabolite Identification Studies for the New Synthetic Opioids Acetylfentanyl, Acrylfentanyl, Furanylfentanyl, and 4-Fluoro-Isobutyrylfentanyl. The AAPS journal, 19(4).
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4

Sourcing and Characterization of Fentanyl Analogues

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Fentanyl, 4-ANPP, Valeryl Fentanyl, Furanyl Fentanyl, Methoxyacetyl Fentanyl, Acetyl Fentanyl, Acryl Fentanyl, and 2′-fluoro ortho-FluoroFentanyl were purchased from Cayman Chemical Company (Ann Arbor, MI). Perchloric acid was obtained from Fisher Scientific (Fair Lawn, NJ). Potassium chloride was received from Sigma-Aldrich (St. Louis, MO). Water (18.2 MΩ) was obtained using a Millipore Direct-Q ® UV water purification system (Billerica, MA).
Ott C.E., Perez-Estebañez M., Hernandez S., Kelly K., Dalzell K.A., Arcos‐Martínez M.J., Heras A., Colina Á., & Arroyo‐Mora L.E. (2022). Forensic Identification of Fentanyl and its Analogs by Electrochemical-Surface Enhanced Raman Spectroscopy (EC-SERS) for the Screening of Seized Drugs of Abuse. Frontiers in Analytical Science, 2.
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