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Moxifloxacin hydrochloride

Manufactured by Alcon

Moxifloxacin hydrochloride is a synthetic antimicrobial agent. It is a broad-spectrum fluoroquinolone antibiotic used in the treatment of various bacterial infections.

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2 protocols using moxifloxacin hydrochloride

1

Refractive Lenticule Extraction Protocol

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A single experienced surgeon performed all the surgeries using the VisuMax FS laser system (Carl Zeiss Meditec AG, Jena, Germany) with a 500-kHz repetition rate under topical anesthesia (0.5% proparacaine hydrochloride, Sunways Pvt. Ltd., Maharashtra, India) instilled two to three times under aseptic precautions. Laser cut energy index was 170 nJ. Spot spacing was 2 μm for creation of the lenticule side cut and 4.5 μm for creation of the lenticule. Lenticule and cap diameter was 6.0 and 7.7 mm, respectively. Intended cap thickness was 110 μm. After the refractive lenticule was created, it was dissected and separated through the side-cut opening and removed manually. No fluid hydration or intraoperative massaging of the cornea was performed after lenticule removal. At the end of the procedure, the cornea was moistened with a wet merocel sponge. A drop of moxifloxacin hydrochloride 0.5% (Vigamox, Alcon Laboratories, Inc, Fort Worth, TX) was instilled in both eyes and the procedure was completed. Postoperative treatment included 0.5% moxifloxacin hydrochloride four times a day for 1 week, tapering dose of topical 1% prednisolone acetate suspension (Pred Forte, Allergan, Inc., Irvine, CA) starting from four times a day to once daily for 3 days each and a topical lubricant (Optive, Allergan, Inc.) four times a day for a month.
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2

Femtosecond Laser Refractive Surgery

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All surgeries were performed by a single experienced surgeon (R.S.) using the VisuMax femtosecond laser system with a 500 kHz repetition rate and pulse energy of 130 nJ. Preoperative anesthesia comprised proparacaine hydrochloride 0.5% (Paracain, Sunways Pvt Ltd, India) instilled 2 to 3 times under aseptic conditions. Laser cut energy index was preset at 170 nJ, and spot spacing ranged from 2 for the lenticule to 4.5 μm for the lenticular side cut, track distance was 3 mm, and lenticule diameter (optical zone) was 6.0 mm. The cornea above the anterior lenticular surface is referred to as the cap, and its diameter was 7.7 mm. The intended cap thickness was 110 μm. After the femtosecond laser cutting procedure, a standard lamellar corneal surgical technique of swiftly sweeping the dissector across the anterior interface followed by the posterior interface was employed (Fig. 1). Once both layers were separated, the lenticule was removed from the cornea using a pair of microforceps. Postoperative treatment included moxifloxacin hydrochloride 0.5% (Vigamox, Alcon Laboratories, Inc, Fort Worth, TX) for 1 week, topical prednisolone acetate 1% suspension (Pred Forte, Allergan, Inc, Irvine, CA) tapering dose over 2 weeks, and a lubricant (Optive, Allergan, Inc, Irvine, CA) for a month.
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