Synapt g2 si quadrupole tof

Manufactured by Waters Corporation

The Synapt G2-Si (Quadrupole/TOF) is a high-performance mass spectrometry instrument that combines a quadrupole and a time-of-flight (TOF) analyzer. It is designed for accurate and sensitive detection and analysis of a wide range of molecular species. The instrument's core function is to ionize, separate, and detect analytes based on their mass-to-charge ratio.

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Lab products found in correlation

Uplc binary pump, by Waters Corporation (1 mentions) 4000 series explorer software, by AB Sciex (1 mentions) Peaks studio software, by Bioinformatics Solutions (1 mentions) Leucine enkephaline solution, by Waters Corporation (1 mentions) Sodium formate solution, by Merck Group (1 mentions)

Spelling variants of this product

Synapt G2-Si (145 citations) Synapt G2 (120 citations) Synapt G2-Si quadrupole time of flight (Q-TOF) mass spectrometer (3 citations) Synapt G2‐Si HDMS quadrupole time‐of‐flight (Q‐TOF) mass spectrometer (2 citations)

2 protocols using synapt g2 si quadrupole tof

Comprehensive Analytical Techniques for Sample Characterization

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Example 2

LC/MS analyses were conducted on a Shimadzu Prominence LCMS-2020 system equipped with an ElectroSpray Ionization (ESI) probe and using a Kinetex® column (4.6 mm×100 mm, 2.6 m XB-C18, 100 Å, 1.8 mL/min) and a 10.5 min. gradient from water (0.1% HCOOH) and CH₃CN (0.1% HCOOH) (CH₃CN 10-100%) and detection at 220 nm and 254 nm. High Resolution Mass Spectrometry (HRMS) was performed on a Waters Synapt G2-Si (Quadrupole/TOF) equipped with a Waters UPLC binary pump and an FTN (Flow-Through Needle) injector. The mass spectrometer was operated in High resolution mode; calibration was performed using a sodium formate solution; and lock-mass correction was performed using a Leucine-enkephalin solution (Waters). Matrix-Assisted Laser Desorption Ionization Time-of-Flight (MALDI-TOF) mass spectrometry was performed using a AB SCIEX 4800 Plus MALDI-TOF/TOF® instrument equipped with an alpha-cyano-4-hydroxycinnamic acid matrix. The spectra were acquired using the 4000 Series Explorer Software (Ab Sciex, v 3.2.3). The PEAKS Studio software (Bioinformatics Solutions, v.7.0) was used for spectra analysis and DENOVO sequencing.

US11571456B2. Process for the linear synthesis of gram-positive class II bacteriocins and compositions and uses thereof (2023-02-07). UNIVERSITÉ LAVAL [CA]. Inventors: François Bédard [CA], Éric Biron [CA], Riadh Hammami [CA], Ismail Fliss [CA].

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Analytical Characterization of Chemical Compounds

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All the chemical reagents and solvents from commercial sources were used without further purification. Amino acid derivatives were purchased from Matrix Innovation (Quebec, QC, Canada). tert-Butyl-(4-aminobutyl)carbamate and 4-tert-butoxybenzylamine building blocks were prepared as previously described. High-resolution mass spectrometry was performed on a Waters Synapt G2-Si (Quadrupole/TOF) with a Waters UPLC binary pump and FTN injector. The mass spectrometer was operated in High resolution mode and calibration performed with a sodium formate solution (Sigma) and lock-mass correction using a leucine-enkephaline solution (Waters).

Vézina-Dawod S., Perreault M., Guay L.D., Gerber N., Gobeil S, & Biron E. (2021). Synthesis and biological evaluation of novel 1,4-benzodiazepin-3-one derivatives as potential antitumor agents against prostate cancer. Bioorganic & medicinal chemistry, 45.

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