Qicpic tm system

The granule size distributions were analysed via dynamic image analysis using the QICPIC TM system (Sympatec, Clausthal-Zellerfeld, Germany), equipped with a vibrating feeder system (Vibri/L TM ) for gravimetric feeding of granules. The WINDOX 5 software (Sympatec, Clausthal-Zellerfeld, Germany)
was used to calculate the median granule size (d50) as the diameter of a circle of equal projection area.
The percentage of fines, yield and oversized granules were defined as the fractions <150 µm, between 150 and 1500 µm and >1500 µm, respectively. The breakage ratio was calculated to quantify the breakage of granules after fluid bed drying by Equation 2:
where d50 and d50, BD represent the median granule size after FBD and median granule size obtained with tray-drying, respectively.

The granule size of milled and unmilled granules was determined via dynamic image analysis using the QICPIC TM system (Sympatec, Clausthal-Zellerfeld, Germany) equipped with a vibrating feeder system (Vibri/L TM ) for gravimetrical feeding of the granules. Samples of 20 g were measured in duplicate. Windox 5 software (Sympatec, Clausthal-Zellerfeld, Germany) was used to calculate the median granule size (d50) as the equivalent projected circle diameter based on a volume distribution. The fines and oversized granules were defined as the fractions <150 µm and >1500 µm, respectively.
The yield of the process was defined as the percentage of granules between 150 and 1500 µm.

Granule size was analyzed before and after milling via dynamic image analysis using the QICPIC TM system (Sympatec, Clausthal-Zellerfeld, Germany) equipped with a vibrating feeder system (Vibri/L TM ) for gravimetrical feeding of the granules.
Samples of 20 g were measured in duplicate. Windox 5 software (Sympatec, Clausthal-Zellerfeld, Germany) was used to calculate the median granule size (d 50 )
as the equivalent projected circle diameter based on a volume distribution. The amounts of fines and oversized granules were defined as the fractions <150 µm and >1500 µm, respectively. The yield of the process was defined as the percentage of granules between 150 and 1500 µm.