Prism 8 for mac osx

Manufactured by GraphPad

Sourced in United States

Prism 8 for Mac OSX is a data analysis and graphing software. It provides tools for data analysis, curve fitting, and graph creation. The software is compatible with Mac OSX operating systems.

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Prism 8 (45576 citations) GraphPad Prism for Mac (47 citations) Prism 8 for Mac (21 citations)

7 protocols using prism 8 for mac osx

Statistical Analysis of Treatment Groups

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Analyses were performed with Prism 8 for Mac OSX (Prism). Comparison of multiple treatment groups were made using 1-way analysis of variance (Tukey’s Multiple Comparisons Test). An unpaired t test was used for 2 groups.

Kiser Z.M., Lizcano A., Nguyen J., Becker G.L., Belcher J.D., Varki A.P, & Vercellotti G.M. (2019). Decreased Erythrocyte Binding of Siglec-9 Increases Neutrophil Activation in Sickle Cell Disease. Blood cells, molecules & diseases, 81, 102399.

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Comparative Analysis of Treatments

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Data are presented as mean standard deviation of mean if not otherwise indicated. Data were tested for normal distribution using the Kolmogorov-Smirnov test. Normal distribution was assumed when α > 0.1. T-tests were performed to detect pairwise differences within and between groups. For all tests, after Bonferroni correction for multiple comparisons, statistical significance was presumed at P < 0.05. Statistical analysis was performed using PRISM 8 for MAC OS X (La Jolla, CA, USA).

Schündeln M.M., Höppner J., Meyer F.L., Schmuck W., Kauther M.D., Hilken G., Levkau B., Rauner M, & Grasemann C. (2021). Prednisone prevents particle induced bone loss in the calvaria mouse model. Heliyon, 7(8), e07828.

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Skeletal Muscle Contractility Analysis

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Depending on data normality, tested with Shapiro–Wilk test, the following parametric or non‐parametric statistical tests were used. Comparisons between two groups were conducted with two‐tailed t‐test or Mann–Whitney U test. In instances where more than two groups needed to be compared, one‐way analysis of variance (ANOVA) or Kruskal–Wallis one‐way ANOVA were performed. Two‐way mixed ANOVAs [groups (CRE‐ littermate controls vs. FoxP1^iSkmTg/Tg) × treatment (vehicle vs. tamoxifen)] were used to test for differences in tissue masses as well as to evaluate differences between groups (CRE‐ littermate controls vs. FoxP1^iSkmTg/Tg) in forces evoked at different frequencies or throughout the fatiguing protocol. When ANOVAs detected differences, Tukey (for one‐way ANOVA), Dunn's (for Kruskal–Wallis one‐way ANOVA), and Sidak (two‐way ANOVA) post hoc analyses were used to test for differences among pairs of means. The alpha level of significance was set to 0.05. Data are reported as mean ± standard error. All statistical analyses were performed with SigmaPlot software for Windows (version 11, Systat, Chicago, IL, USA) and Prism 8 for MacOS X (GraphPad Software, La Jolla, CA, USA). Prism 8 was also used for figures.

Neyroud D., Nosacka R.L., Callaway C.S., Trevino J.G., Hu H., Judge S.M, & Judge A.R. (2021). FoxP1 is a transcriptional repressor associated with cancer cachexia that induces skeletal muscle wasting and weakness. Journal of Cachexia, Sarcopenia and Muscle, 12(2), 421-442.

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Detailed Statistical Analysis Protocol

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All values are given as mean ± SEM. Statistical analyses were performed using PRISM 8 for Mac OS X (GraphPad Software, Inc., La Jolla, CA). Data were tested for normality and equal variance to confirm the appropriateness of parametric tests. Data that followed a normal distribution were analyzed by Student t test, Welch t test, one-way ANOVA with Tukey post hoc test, or two-way ANOVA with Tukey or Sidak post hoc tests, where appropriate. Data that failed normal distribution were analyzed by Mann-Whitney U test or by Kruskal-Wallis test with Dunn post hoc test. A P value of less than 0.05 was considered significant.

Takanashi M., Kimura T., Li C., Tanaka M., Matsuhashi A., Yoshida H., Noda A., Xu P., Takase S., Okazaki S., Iizuka Y., Kumagai H., Ikeda Y., Gotoda T., Takahashi M., Yagyu H., Ishibashi S., Yamauchi T., Kadowaki T., Liang G, & Okazaki H. (2019). Critical role of SREBP-1c large-VLDL pathway in environment-induced hypertriglyceridemia of apoA-V deficiency. Arteriosclerosis, thrombosis, and vascular biology, 39(3), 373-386.

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Cocaine Sensitivity and Dopamine Receptor Expression

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All statistical tests were performed using Prism 8 for Mac OSX (GraphPad Software, LLC; San Diego, CA, USA); differences were considered statistically significant when p<0.05. D2R availability in each brain region was quantified as the distribution volume ratio (DVR) using the cerebellum as the reference region. Pearson correlations were computed between D2R availability ([¹¹C]raclopride DVR) in each brain region and two measures of sensitivity to cocaine: the dose at which acquisition occurred and the potency of cocaine as a reinforcer during determination of the initial self-administration curve, quantified as the ED₅₀ of each monkey’s curve (See Tryhus et al. 2021 ). Next, correlations were computed between D₃R sensitivity (ED₅₀ of the quinpirole-induced yawning curve, see Say et al. 2022 (link)) and the same two measures of cocaine self-administration. Note that because “dose at acquisition” is an ordinal rather than continuous variable, a non-parametric Spearman correlation was used for those analyses.

Wiederrecht G., Brizuela L., Elliston K., Sigal N.H, & Siekierka J.J. (1991). FKB1 encodes a nonessential FK 506-binding protein in Saccharomyces cerevisiae and contains regions suggesting homology to the cyclophilins.. Proceedings of the National Academy of Sciences of the United States of America, 88(3), 1029-1033.

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Morphine Analgesic Efficacy with NFP

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Tail-withdrawal latencies were recorded for each mouse and data were expressed as percent maximum possible effect (%MPE) as follows: [(test-baseline)/(10-baseline)*100]. Control data represented %MPE values obtained after administration of saline (morphine vehicle) and either 0.3 mg/kg NFP or saline (NFP's vehicle) on the respective test day. Within-group analyses were conducted separately for %MPE data generated during Day 1 and Day 7 for each group using a repeated measure ANOVA with morphine dose as the within-subjects factor. Fisher’s LSD post-hoc tests were used to identify significant differences of morphine dose vs control. Separate two-way ANOVAs comparing %MPE scores between the Vehicle and NFP groups during Day 1 and Day 7 were additionally conducted. Data were subsequently analyzed using Fisher’s LSD post-hoc tests comparing Vehicle and NFP groups at each morphine dose on each day. All statistical tests were conducted using microcomputer software (Prism 8 for Mac OSX, GraphPad Software, Inc., San Diego, CA), and all types of comparisons were considered statistically significant if P < 0.05.

Zheng Y., Obeng S., Reinecke B.A., Chen C., Phansalkar P.S., Walentiny D.M., Gerk P.M., Liu-Chen L.Y., Selley D.E., Beardsley P.M, & Zhang Y. (2019). Pharmacological characterization of 17-cyclopropylmethyl-3,14-dihydroxy-4,5-epoxy-6-[(3’-fluoro-4’-pyridyl)acetami do]morphinan (NFP) as a dual selective MOR/KOR ligand with potential applications in treating opioid use disorder. European journal of pharmacology, 865, 172812.

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Cocaine Reinforcement in Ethanol Drinkers

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All statistical tests were performed using Prism 8 for Mac OSX (GraphPad Software, LLC; San Diego, CA, USA); differences were considered statistically significant when p<0.05. To determine whether there were differences in sensitivity to acquisition of cocaine reinforcement between ethanol drinkers and controls, a log-rank (Mantel-Cox) analysis of Kaplan-Meier survival curves was performed. To compare the reinforcing potency of cocaine between the groups, the ED₅₀ of the ascending limb of the initial cocaine dose-effect curve was calculated by interpolation of the linear portion of the curve. A two-tailed, unpaired t-test compared these values between groups.

Tryhus A.M., Epperly P.M., Davenport A.T., Galbo L.K, & Czoty P.W. (2021). Effect of chronic binge-like ethanol consumption on subsequent cocaine reinforcement in rhesus monkeys. Drug and alcohol dependence, 223, 108707.

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