Disodium monohydrogen phosphate

SilMA was prepared from silk fibroin from Bombyx mori according to the protocol reported in [23 (link)]; Hepcidin-25 and fluorescent hepcidin (hepfitc) were from Promega (UK); Lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) was from TCI Chemicals (US); Tris(hydroxymethyl)aminomethane (Tris base), morpholino-ethane sulfonate (MES), sodium dihydrogen phosphate, disodium mono-hydrogen phosphate, sodium chloride, Kalium chloride, human serum albumin, angiotensin, cytochrome c, and serum sample were from Merck Sigma Aldrich (Darmstadt, Germany). All reagents were of commercial grade and used as received.

Galantamine hydrobromide was purchased from Xi'an Yiyang Bio-Tech (Xi'an City, China). Carbopol 940 was bought from Fisher Scientific (Waltham, MA, USA). Triethanolamine, propylene glycol, sodium chloride, potassium chloride, monopotassium phosphate, disodium monohydrogen phosphate, and sodium hydroxide were obtained from Merck (Darmstadt, Germany). Trifluoroacetic acid and acetonitrile were obtained from Avantor Performance Materials (Center Valley, PA, USA). All chemicals were of reagent or analytical grade and were used without further purification.

Norfloxacin (>98%), resorcinol (>99%), and toluene (>99.5%) were purchased from Sigma Aldrich (Darmastadt, Germany). Norfloxacin was a mixture of polymorph A, polymorph C, and the sesquihydrate Form I (Ref Code PUZGAT). See Figure S1 for further details [31 (link)].
The following chemicals were used to prepare buffer solutions: ethylenediamine (>98.8%) from J. T. Baker (Radnor, PA, USA), and trifluoroacetic acid (>99%) and acetic acid (>99%) from Merck (Darmastadt, Germany). To reach the desired pH value, 1 M sodium hydroxide Titrisol^® or 0.5 M hydrochloric acid Titrisol^®, also from Merck, were added.
For the dissolution rate determination, the following reagents were used: dimethyl sulfoxide (>99.9%, DMSO), potassium dihydrogen phosphate (>99.5%), 0.5 M potassium hydroxide Titrisol^®, and 0.5 M hydrochloric acid Titrisol^®, all from Merck. Potassium chloride (>99%) was from Sigma.
For HPLC quantification, acetonitrile (HPLC gradient-grade) from Fisher Scientific (Hampton, NH, USA) and a mixture of sodium dihydrogen phosphate monohydrate (>99%) and disodium monohydrogen phosphate (>99%) from Merck were used.
Water was purified by a Milli-Q plus system from Millipore (Bedford, MA, USA), with a resistivity of 18.2 MΩ cm.