Il 4 clone 11b11

Manufactured by BioXCell

Sourced in United States

IL-4; clone 11B11 is a monoclonal antibody that binds to and neutralizes the cytokine interleukin-4 (IL-4). It is commonly used in research applications to study the role of IL-4 in various biological processes.

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Lab products found in correlation

Isotype control antibody, by BioXCell (1 mentions) Clone r4 6a2, by BioXCell (1 mentions) Clone 17f3, by BioXCell (1 mentions)

2 protocols using il 4 clone 11b11

Modulating Corneal Inflammation with Cytokine Antibodies

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As previously described, we used monoclonal antibodies against mouse interleukin-4 (IL-4; clone 11B11; 5 μg/g/dose; Bio-X-cell, West Lebanon, NH, USA) or rat antibody against mouse IL-13 (clone 38213; 5 μg/g; R&D Systems, Minneapolis, MN, USA), and administered them intraperitoneally [16 (link)]. Controls were treated with similar doses of isotype control antibodies (Bio-X-cell). Mice were treated with IL-4 monoclonal antibody (mAb), IL-13mAb, or isotype control antibodies 24 hours prior to corneal surgery, then weekly (IL-4mAb) or every 4 days (IL-13mAb) for 2 weeks after surgery.

Savetsky I.L., Ghanta S., Gardenier J.C., Torrisi J.S., García Nores G.D., Hespe G.E., Nitti M.D., Kataru R.P, & Mehrara B.J. (2015). Th2 Cytokines Inhibit Lymphangiogenesis. PLoS ONE, 10(6), e0126908.

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Cytokine Neutralization for CCA Tumor Model

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IFNγ, IL4, or IL17a neutralization was performed by i.p. injections of 100 µg of rat IgG1 antibodies targeting IFNγ (clone R4-6A2; BioXCell), IL4 (clone 11B11; BioXcell), or IL17a (clone 17F3; BioXCell) at the following time points: 3 d and 1 d before CCA cell engraftment, then 1 d after, then repeated three times a week throughout the whole course of the experiment. Isotype control (clone HRPN; BioXCell) was delivered i.p. at the same dose and time points.

Paillet J., Plantureux C., Lévesque S., Le Naour J., Stoll G., Sauvat A., Caudana P., Tosello Boari J., Bloy N., Lachkar S., Martins I., Opolon P., Checcoli A., Delaune A., Robil N., de la Grange P., Hamroune J., Letourneur F., Autret G., Leung P.S., Gershwin M.E., Zhu J.S., Kurth M.J., Lekbaby B., Augustin J., Kim Y., Gujar S., Coulouarn C., Fouassier L., Zitvogel L., Piaggio E., Housset C., Soussan P., Maiuri M.C., Kroemer G, & Pol J.G. (2021). Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma. The Journal of Experimental Medicine, 218(10), e20200853.

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