Biograph 16hr pet ct scanner

Manufactured by Siemens

Sourced in United States

The Biograph 16HR PET/CT scanner is a medical imaging device that combines positron emission tomography (PET) and computed tomography (CT) technologies. It is designed to capture high-resolution images of the body's metabolic and anatomical structures.

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Lab products found in correlation

Cti rds eclipse st, by Siemens (4 mentions) Cti rds eclips st, by Siemens (1 mentions) Explora fdg4 module, by Siemens (1 mentions)

Close spelling variants of this product

Biograph PET/CT scanner (30 citations) Biograph 16HR (11 citations) Siemens scanners (11 citations) PET/CT scanner (10 citations) CT scanners (7 citations) Biograph 16HR PET/CT (3 citations)

14 protocols using biograph 16hr pet ct scanner

Automated Production and Imaging Protocol for 18F-FDG PET/CT

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¹⁸ F-FDG was produced automatically by cyclotron (Siemens CTI RDS Eclips ST, Knoxville, Tennessee, USA) using Explora FDG₄ module in our center. Radiochemical purity was over 95%.
Before the ¹⁸ F-FDG PET/CT, all the patients were requested to fast at least 4 h. At the time of the tracer injection (dosage: 7.4 MBq/kg), the patients presented blood glucose level under 10 mmol/L. Before and after injection, patients were kept lying comfortably in a quiet, dimly lit room. Scanning was initiated 1 h after administration of the tracer. The images were obtained on a Siemens biograph 16HR PET/CT scanner (Knoxville, Tennessee, USA). The transaxial intrinsic spatial resolution was 4.1 mm (full-width at half-maximum) in the center of the field of view. The data acquisition procedure was as follows: CT scanning was first performed, from the proximal thighs to head, with 120 kV, 80 ~ 250 mA, pitch 3.6, rotation time 0.5. Immediately after CT scanning, a PET emission scan that covered the identical transverse field of view was obtained. Acquisition time was 2 ~ 3 min per table position. PET image data sets were reconstructed iteratively by applying the CT data for attenuation correction, and coregistered images were displayed on a workstation.

Yang Z., Shi Q., Zhang Y., Pan H., Yao Z., Hu S., Shi W., Zhu B., Zhang Y, & Hu C. (2015). Pretreatment 18 F-FDG uptake heterogeneity can predict survival in patients with locally advanced nasopharyngeal carcinoma——a retrospective study. Radiation Oncology (London, England), 10, 4.

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FLT-PET/CT Imaging for Locoregionally Advanced Nasopharyngeal Carcinoma

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According to the inclusion criteria, all enrolled patients received FLT-PET/CT scan at the completion of CIRT, which was defined to be performed one week prior to or after completion of CIRT. Images of FLT-PET/CT for patients with LR-NPC are illustrated in Figure 1.FLT-PET/CT was performed using a Siemens biograph 16HR PET/CT scanner (Knoxville, Tennessee, USA). Scanning was initiated 1h after administration of the trace (dosage: 7.4 MBq/kg). The trans-axial intrinsic spatial resolution was 4.1 mm (full-width at half-maximum) in the center of the field of view. The data acquisition procedure was as follows: emission images of 3-4 bed positions from head to base of lung were recorded, with 2-3 min per bed position in 3-dimensional mode. CT images were acquired for anatomic correlation and attenuation correction using 120kV, 80~250mA, pitch 3.6, rotation time 0.5 and no contrast agent was allowed.

Hu J., Yang Z., Gao J., Hu W., Yang J., Qiu X., Zhang Y., Ma G., Kong L, & Lu J.J. (2020). Volumetric parameters derived from FLT-PET performed at completion of treatment predict efficacy of Carbon-ion Radiotherapy in patients with locally recurrent Nasopharyngeal Carcinoma. Journal of Cancer, 11(23), 7073-7080.

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FDG PET/CT Imaging for Skeletal Metastases

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All the patients fasted for 4–6 h before PET/CT and their blood glucose levels were under 10 mmol/L at the time of FDG injection. Examination was initiated 1 h after i.v. injection of FDG (7.4 MBq/kg). FDG PET/CT scanning was performed on Siemens biograph 16HR PET/CT scanner (Knoxville, Tennessee, USA). First, unenhanced low-dose CT scans (120 kV automatic mA, modulation range of 130–370 mA) were acquired. Immediately after CT scans, three-dimensional PET scans were acquired (3–4 min per bed position). PET data were reconstructed iteratively by applying CT data for attenuation correction, and co-registered images were displayed on a workstation.
Images were reviewed and manipulated in a multimodality computer platform (Syngo, Siemens, Knoxville, Tennessee, USA). Two experienced nuclear medicine physicians, unaware of patients’ clinical information, evaluated the images independently. The reviewers reached a consensus in cases of discrepancy. FDG uptakes of lesions were measured as the maximum standardized uptake value (SUVmax).
Criteria for diagnosing of skeletal metastases by FDG PET/CT are increased standardized uptake value (SUV) on PET image, and osteoblastic lesions, osteolytic lesions, mixed osteoblastic/osteolytic lesions, or no demonstrable anatomical change on CT image. Presence of fracture lines or callus formation was interpreted as a fracture.

Zhu M., Liu X., Qu Y., Hu S., Zhang Y., Li W., Zhou X., Yang H., Zhou L., Wang Q., Hou Y., Chen Y., Wang Y., Wang Y., Lu Z., Luo Z, & Hu X. (2019). Bone metastasis pattern of cancer patients with bone metastasis but no visceral metastasis. Journal of Bone Oncology, 15, 100219.

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Whole-Body FDG PET/CT Imaging Protocol

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The whole-body FDG PET/CT was performed as previously described [24 (link)]. Briefly, ¹⁸F-FDG was made automatically by cyclotron (Siemens CTI RDS Eclipse ST; Knoxville, TN, USA) using an Explora FDG4 module. Patients had been fasting for more than 6 h. Scanning was started 1 h after intravenous injection of the tracer (7.4 MBq/kg). The images were acquired on a Siemens biograph 16HR PET/CT scanner with a transaxial intrinsic spatial resolution of 4.1 mm. CT scanning was first initiated from the proximal thighs to the head, with 120 kV, 80–250 mA, pitch 3.6, and rotation time 0.5 s. Image interpretation was carried out on a multimodality computer platform (Syngo; Siemens). Quantification of metabolic activity was acquired using the standardized uptake value (SUV) normalized to bodyweight and the maximum SUV (SUVmax) for each lesion was calculated.

Li Q., Li Y., Liang L., Li J., Luo D., Liu Q., Cai S, & Li X. (2018). Klotho negatively regulated aerobic glycolysis in colorectal cancer via ERK/HIF1α axis. Cell Communication and Signaling : CCS, 16, 26.

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Automated Production and Quantification of 18F-FDG PET/CT

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¹⁸F-FDG was produced automatically by cyclotron (Siemens CTI RDS Eclipse ST, Knoxville, Tennessee, USA) using the Explora FDG4 module in our center, and the radiochemical purity was over 95%. All patients fasted at least 6 h and the venous blood glucose levels were maintained under 10 mmol/L before ¹⁸F-FDG injection (7.4 MBq/kg). Patients were required to be quiet after injection for approximately 1 h. Siemens biograph 16HR PET/CT scanner (Knoxville, Tennessee, USA) was performed for scanning. The transaxial intrinsic spatial resolution was 4.1 mm (full-width at half-maximum) in the center of the view. CT scanning (120 kV, 80–250 mA, pitch 3.6, rotation time 0.5) from the proximal thighs to the head was first performed for data acquisition, following by a PET emission scan. The acquisition time was 2–3 min/bed. PET image data sets were iteratively reconstructed using the attenuation correction of CT data, and the infused images were displayed on a workstation. The reconstructed images were then converted to a semiquantitative image corrected by the injection dose and the subject’s body weight (SUV).

Liu S., Xia L., Yang Z., Ge H., Wang C., Pan H., Song S, & Zhou Z. (2020). The feasibility of 18F-FDG PET/CT for predicting pathologic risk status in early-stage uterine cervical squamous cancer. Cancer Imaging, 20, 63.

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Glucose Uptake in Pancreatic Cancer

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To assess the correlation between PRMT5 and glucose uptake in pancreatic cancer patients, we examined the SUVmax in pancreatic cancer patients via PET/CT imaging, a technique that measures glucose uptake via glycolysis by assessing 18F-FDG uptake. The SUVmax was obtained and calculated according to our previous reports. Briefly, ¹⁸F-FDG was automatically made in a cyclotron (Siemens CTI RDS Eclipse ST) using an Explora FDG4 module. Patients were fasted for more than 6 h. Scanning started 1 h after intravenous injection of the tracer (7.4 MBq/kg). Images were acquired on a Siemens biograph 16HR PET/CT scanner with a transaxial intrinsic spatial resolution of 4.1 mm. CT scanning was initiated from the proximal thighs to the head at 120 kV and 80–250 mA with a pitch of 3.6 and a rotation time of 0.5 s. Image interpretation was carried out on a multimodality computer platform (Syngo, Siemens). Metabolic activity was quantified using the SUVs normalized to the body weights of the patients, and the SUVmax for each lesion was calculated [29 (link)].

Qin Y., Hu Q., Xu J., Ji S., Dai W., Liu W., Xu W., Sun Q., Zhang Z., Ni Q., Zhang B., Yu X, & Xu X. (2019). PRMT5 enhances tumorigenicity and glycolysis in pancreatic cancer via the FBW7/cMyc axis. Cell Communication and Signaling : CCS, 17, 30.

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18F-FES PET/CT Imaging Protocol

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All of the chemicals were obtained from commercial sources and were used without further purification. The MMSE precursor and the authentic ¹⁸F-FES was purchased from Jiangsu Huayi Chemical Co, Ltd. (Suzhou, Jiangsu, China). ¹⁸F-FES was prepared according to the published methods [16 (link)]. To prevent ¹⁸F-FES false-negative results, ER antagonists were discontinued for a minimum of 5 weeks before the study. The use of aromatase inhibitors was allowed [17 (link)]. All of the patients received an injection of approximately 222 MBq (6 mCi) of ¹⁸F-FES over 2 min. Scanning consisted of a whole-body PET/CT examination (2–3 min per table position) initiated 1 h after the administration of the tracer on a Siemens biograph ¹⁶HR PET/CT scanner. The transaxial intrinsic spatial resolution was 4.1 mm (full width at half maximum) in the center of the field of view. The PET/CT data acquisition protocol was as follows: CT scanning was first acquired from the proximal thighs to the head using a low-dose technique (120 kV, 80–250 mA, pitch 3.6, rotation time 0.5 ms). Immediately after the CT scan, a PET emission scan that covered the identical transverse field-of-view was obtained. We used a Gaussian-filter iterative reconstruction method to reconstruct the PET images. The coregistered images were displayed on a workstation.

Xie Y., Du X., Zhao Y., Gong C., Hu S., You S., Song S., Hu X., Yang Z, & Wang B. (2022). Chemotherapy Shows a Better Efficacy Than Endocrine Therapy in Metastatic Breast Cancer Patients with a Heterogeneous Estrogen Receptor Expression Assessed by 18F-FES PET. Cancers, 14(14), 3531.

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Standardized 18F-FDG PET/CT Imaging Protocol

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Two patients underwent ¹⁸F-FDG PET/CT examinations at our hospital, and another patient underwent an ¹⁸F-FDG PET/CT examination at a different hospital. All patients were requested to fast at least 4 h before the ¹⁸F-FDG PET/CT scan. At the time of tracer injection (dose: 7.4 MBq/kg), the serum glucose level should be controlled between 3.9 mmol/l and 7.1 mmol/l. Before and after injection, patients were kept lying comfortably in a quiet, dimly lit room. Scanning was initiated 1 h after administration of the tracer. The images were obtained on a Siemens Biograph 16HR PET/CT scanner (Siemens, Munich, Germany). The transaxial intrinsic spatial resolution was 4.1 mm (full-width at half-maximum) in the center of the field of view. The data acquisition procedure was as follows: CT scanning was first performed from the proximal thighs to the head (120 kV, 80,250 mA, pitch 3.6, and rotation time 0.5). Immediately after CT scanning, PET emission scanning that covered the identical transverse field of view was performed. The acquisition time was 2.3 min per table position. PET imaging data sets were reconstructed iteratively by applying the CT data for attenuation correction, and coregistered images were displayed on a workstation^{11 (link)}.

Zhang X., Ni S.J., Wang X.H., Huang D, & Tang W. (2020). Adult pancreatoblastoma: clinical features and Imaging findings. Scientific Reports, 10, 11285.

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Whole-body 18F-FDG PET/CT Imaging Protocol

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The Whole-body ¹⁸F-FDG positron emission tomography/ computed tomography imaging was performed as previously described 47 (link). Patients fasted for at least 8 h to ensure low levels of serum glucose. Scanning started 1 h after intravenous injection of the tracer (7.4 MBq/kg). The images were acquired on a Siemens biograph 16HR PET/CT scanner with a transaxial intrinsic spatial resolution of 4.1 mm. Quantification of metabolic activity was acquired using the standard uptake value (SUV) normalized to body weight, and the SUVmax for each lesion was calculated.

Sun H., Wang H., Wang X., Aoki Y., Wang X., Yang Y., Cheng X., Wang Z, & Wang X. (2020). Aurora-A/SOX8/FOXK1 signaling axis promotes chemoresistance via suppression of cell senescence and induction of glucose metabolism in ovarian cancer organoids and cells. Theranostics, 10(15), 6928-6945.

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PET/CT Imaging Protocol for Tumor and Lymph Node Assessment

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Patients were required to fast for at least 6 h before PET/CT scan. ¹⁸F-FDG was given intravenously at a dose of 7.4 MBq/kg. After resting for 1 h, the PET/CT scan was performed using a Siemens Biograph 16HR PET/CT Scanner (Knoxville, TN, USA). The patient kept a supine position with elbows on the forehead in a full carbon flatbed. The scanning range was from the proximal thighs to the head. CT scanning was performed before PET acquisition. The parameters of CT scanning were as follows: 120 kV, 110 mA, slice thickness of 5 mm, rotation time of 0.5 s, and pitch of 1 mm. The PET scan duration was 2–3 min per bed for 6–8 beds. The PET images were reconstructed using the ordered subset maximum expectation iteration method after attenuation correction using CT images. More details have been described previously.^{22 (link)}SUV-T was defined as the maximum SUV (SUVmax) of the primary tumor, SUV-N was defined as SUVmax of the lymph nodes, and SUV NTR was defined as the lymph NTR of SUVmax. For multiple lymph nodes, SUVmax is defined as the highest SUVmax of the neck lymph nodes, regardless of the size of the lymph nodes.

Kong F.F., Pan G.S., Ni M.S., Du C.R., Hu C.S, & Ying H.M. (2024). Prognostic value of lymph node-to-primary tumor ratio of PET standardized uptake value for nasopharyngeal carcinoma: a recursive partitioning risk stratification analysis. Therapeutic Advances in Medical Oncology, 16, 17588359241233235.

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