Sprague dawley rats

Manufactured by CLEA Japan

Sourced in Japan

Sprague-Dawley rats are a commonly used laboratory animal model in medical and scientific research. They are a strain of albino rats bred for their docile temperament and reliability in experimental studies. Sprague-Dawley rats are known for their adaptability to various environments and their suitability for a wide range of research applications.

Automatically generated - may contain errors

Lab products found in correlation

Isoflurane inhalation solution, by Pfizer (2 mentions) Glutaraldehyde, by Nacalai Tesque (1 mentions) Salmon calcitonin, by Merck Group (1 mentions) Paraformaldehyde (pfa), by Merck Group (1 mentions) Crf 1, by Oriental Yeast (1 mentions) Forteo, by Eli Lilly (1 mentions) Tetracycline, by Fujifilm (1 mentions) Penicillin g potassium, by Meiji Seika Pharma (1 mentions) α mem, by Cytiva (1 mentions) Rapamycin, by LC Laboratories (1 mentions) C57bl 6n, by CLEA Japan (1 mentions) C57bl 6j, by CLEA Japan (1 mentions)

47 protocols using sprague dawley rats

Sprague-Dawley Rat Feeding Protocol

Check if the same lab product or an alternative is used in the 5 most similar protocols

Six-week-old male Sprague-Dawley (SD) rats were purchased from Clea Japan, Inc. (Tokyo, Japan) and allowed free access to tap water and food pellets (Clea Japan, Inc.). All protocols in
this study were approved by the Animal Research Committee and were performed in accordance with the guidelines for animal experiments of the Faculty of Agriculture, Tottori University.

TOMITA N., NAKAMURA T., SUNDEN Y, & MORITA T. (2019). Histopathological and immunohistochemical analysis of the cerebral white matter after transient hypoglycemia in rat. The Journal of Veterinary Medical Science, 82(1), 68-76.

+ Open protocol

+ Expand

Sprague-Dawley Rat Study Protocol

Check if the same lab product or an alternative is used in the 5 most similar protocols

Forty male Sprague–Dawley (SD) rats (age 7 weeks; CLEA Japan, Tokyo, Japan) were employed in this study. All study protocols and procedures were approved by the Animal Care and Use Committee, Kyushu Dental University (Protocol #16-027). This study was conducted in accordance with ARRIVE (Animal Research: Reporting In Vivo Experiments) guidelines and the National Institutes of Health guide for care and use of Laboratory animals.

Sano K., Usui M., Moritani Y., Nakazawa K., Hanatani T., Kondo H., Nakatomi M., Onizuka S., Iwata T., Sato T., Togari A., Ariyoshi W., Nishihara T, & Nakashima K. (2020). Co-cultured spheroids of human periodontal ligament mesenchymal stem cells and vascular endothelial cells enhance periodontal tissue regeneration. Regenerative Therapy, 14, 59-71.

+ Open protocol

+ Expand

Sourcing and Housing of ICR Mice and SD Rats

Check if the same lab product or an alternative is used in the 5 most similar protocols

Male institute of cancer research (ICR) mice and Sprague‐Dawley (SD) rats were supplied by CLEA Japan, Inc. (Tokyo, Japan) and Charles River Laboratories Japan Inc. (Yokohama, Japan), respectively. Animals were housed in a light‐controlled room (12‐h light/12‐h dark cycle with lights on at 07:00 am). After an acclimation period of at least 1 week, 6‐ to 9‐week‐old animals were used. The care and use of the animals and the experimental protocols were approved by the Institutional Animal Care and Use Committee of Takeda Pharmaceutical Company Limited (Osaka and Fujisawa, Japan). Four‐week‐old male SD rats were supplied by Charles River Laboratories Italia (Italy) for the electrophysiological study which was conducted by Aptuit Inc. (Verona, Italy) in accordance with national legislation and under authorization issued by the Italian Ministry of Health. Aptuit Inc. is committed to the highest standards of animal welfare and is subject to legislation under the Italian Legislative Decree no. 26/2014.

Suzuki K., Harada A., Suzuki H., Capuani C., Ugolini A., Corsi M, & Kimura H. (2017). Combined treatment with a selective PDE10A inhibitor TAK‐063 and either haloperidol or olanzapine at subeffective doses produces potent antipsychotic‐like effects without affecting plasma prolactin levels and cataleptic responses in rodents. Pharmacology Research & Perspectives, 6(1), e00372.

+ Open protocol

+ Expand

Rhodopsin S334ter Transgenic Rat Model

Check if the same lab product or an alternative is used in the 5 most similar protocols

The experimental procedures performed in this study conformed to the Association for Research in Vision and Ophthalmology (ARVO) Statement for the Use of Animals in Ophthalmic and Vision Research and were approved by the institutional Committee of Ethics for animal experiments (Approval Number: M11026).
The homozygous rhodopsin S334ter transgenic rats (line 4) were generously provided by Dr. Mathew M LaVail of the University of California. Sprague-Dawley (SD) rats were used as wild type (wt) control rats and were purchased from Clea Japan (Tokyo, Japan). The rats were maintained at the Hirosaki University Graduate School of Medicine Animal Care Service facility under a cycle of 12 h of light (50 lx illumination) and 12 h of darkness (<10 lx environmental illumination) in an air-conditioning atmosphere. Care was taken not to cause light-induced photoreceptor damage. The animals had ad libitum access to food and water.

Yamauchi K., Tanabu R., Monai N., Gonome T., Xie Y., Takahashi S., Ishiguro S.I, & Nakazawa M. (2018). The Spectral-Domain Optical Coherence Tomography Findings Associated with the Morphological and Electrophysiological Changes in a Rat Model of Retinal Degeneration, Rhodopsin S334ter-4 Rats. BioMed Research International, 2018, 5174986.

+ Open protocol

+ Expand

Sprague–Dawley Rat Experiment Protocol

Check if the same lab product or an alternative is used in the 5 most similar protocols

Eight-week-old female Sprague–Dawley (SD) rats weighing 200 g were purchased from CLEA Japan, Inc. (Tokyo, Japan). All animal experiments were approved by the Animal Experiment Committee of the Nihon University School of Medicine (AP10M071-4). All experimental procedures were carried out according to the Guide for the Care and Use of Laboratory Animals: Eighth Edition, Washington, DC: The National Academies Press, 2011.

Murata Y., Obinata D., Matsumoto T., Ikado Y., Kano K., Fukuda N., Yamaguchi K, & Takahashi S. (2022). Urethral injection of dedifferentiated fat cells ameliorates sphincter damage and voiding dysfunction in a rat model of persistence stress urinary incontinence. International Urology and Nephrology, 54(4), 789-797.

+ Open protocol

+ Expand

Sprague-Dawley Rat Study: Ethical Procedures

Check if the same lab product or an alternative is used in the 5 most similar protocols

Eight-week-old male Sprague-Dawley (SD) rats (CLEA Japan, Inc, Tokyo, Japan) were
used in this study. The experimental procedures and protocols were approved by
the Animal Ethics Committee of Keio University Tokyo, Japan (approval number:
A2022-044), and were conducted in accordance with the Guide for the Care and Use
of Laboratory Animals (National Institutes of Health, Bethesda, MD, USA).

Kojima H., Kushige H., Yagi H., Nishijima T., Moritoki N., Nagoshi N., Nakano Y., Tanaka M., Hori S., Hasegawa Y., Abe Y., Kitago M., Nakamura M, & Kitagawa Y. (2023). Combinational Treatment Involving Decellularized Extracellular Matrix Hydrogels With Mesenchymal Stem Cells Increased the Efficacy of Cell Therapy in Pancreatitis. Cell Transplantation, 32, 09636897231170437.

+ Open protocol

+ Expand

Sprague-Dawley Rat Housing and Acclimation

Check if the same lab product or an alternative is used in the 5 most similar protocols

Five-week-old male Sprague–Dawley (SD) rats were purchased from CLEA Japan, Inc. (Tokyo, Japan). Two or three rats were housed in a plastic rat cage (24.7 cm × 40.9 cm × 19.7 cm) with free access to tap water and laboratory animal feed (Oriental Yeast Co., Ltd., Tokyo, Japan) under a 12 h light/dark cycle (lights on/off at 8:00 a.m./p.m.) at 25°C ± 1°C and 50%–60% humidity. All animals were used for experiments after an acclimation period of 1 week. The experimental protocol was approved by the Wakayama Medical University Animal Experiment Committee (Nos 883 and 1050).

Yamamoto Y., Narumi K., Yamagishi N., Nishi T., Ito T., Iseki K., Kobayashi M, & Kanai Y. (2023). Oral administration of linoleic acid immediately before glucose load ameliorates postprandial hyperglycemia. Frontiers in Pharmacology, 14, 1197743.

+ Open protocol

+ Expand

Rat Tissue Characterization Protocol

Check if the same lab product or an alternative is used in the 5 most similar protocols

Sprague-Dawley (SD) rats were obtained from CLEA Japan Inc. (Tokyo, Japan). Glutaraldehyde was from Nakalai Tesque (Kyoto, Japan) and paraformaldehyde was from Merck (Darmstadt, Germany). ADM (rat) and calcitonin gene-related peptide (CGRP) (rat) were purchased from Bachem AG (Bubendorf, Switzerland) and peptide laboratory (Osaka, Japan). Salmon calcitonin was obtained from Sigma (St. Louis, MD). 125 I-labeled ADM (rat) (74 TBq/mmol) was purchased from Amersham Pharmacia Biotech (Buckinghamshire, UK). NR-M2 autoradiographic emulsion was obtained from Konica (Kyoto, Japan). 1α,25-Dihydroxyvitamin D 3 was purchased from Enzo Life Sciences (Farmingdale, NY). Sephadex G10 and tartrate-resistant acid phosphatase kits were obtained from Millipore-Sigma (Burlington, MA). Anti-endomucin antibody rat mAb (IgG2a) and anti-cathepsin K antibody (E-7) mouse mAb (IgG3k) were obtained from Santa Cruz (Dallas, TX).

Kukita T., Hiura H., Gu J.Y., Zhang J.Q., Kyumoto-Nakamura Y., Uehara N., Murata S., Sonoda S., Yamaza T., Takahashi I, & Kukita A. (2021). Modulation of osteoclastogenesis through adrenomedullin receptors on osteoclast precursors: initiation of differentiation by asymmetric cell division. Laboratory investigation; a journal of technical methods and pathology, 101(11).

+ Open protocol

+ Expand

Fatty Rats in Controlled Environment

Check if the same lab product or an alternative is used in the 5 most similar protocols

Male SDT fa/fa (fatty) rats and age-matched Sprague-Dawley (SD) rats were purchased from CLEA Japan, Inc. (Tokyo, Japan). Rats were housed in a climate-controlled room at a temperature of 23±3 °C, humidity of 55±15 %, and a 12 h lighting cycle. A powdered basal diet (CRF-1, Oriental Yeast Co., Ltd., Tokyo, Japan) and water were provided ad libitum. All experiments received prior approval from the committee for human care and use of animals at our laboratory in accordance with the Standards Relating to the Care and Management of Experimental Animals.

Motohashi Y., Kemmochi Y., Maekawa T., Tadaki H., Sasase T., Tanaka Y., Kakehashi A., Yamada T, & Ohta T. (2018). Diabetic macular edema-like ocular lesions in male spontaneously diabetic torii fatty rats. Physiological research, 67(3).

+ Open protocol

+ Expand

Bone Regeneration with rhBMP-2 and PTH

Check if the same lab product or an alternative is used in the 5 most similar protocols

A total of 72 male Sprague–Dawley rats (8–10 weeks old; CLEA Japan, Inc., Tokyo, Japan) were divided into four groups. Group I (n = 12) included animals that were implanted with control carrier alone. Group II (n = 12) included animals that were implanted with carrier containing 1 μg of rhBMP-2. Group III (n = 12) included animals that were implanted with carrier alone, followed by injections of PTH 1-34 (Forteo; Eli Lilly and Company, Indianapolis, IN). Group IV (n = 12) included animals that were implanted with carrier containing 1 μg of rhBMP-2, followed by injections of PTH 1-34. Group V included animals that were implanted with carrier containing 10 μg of rhBMP-2. Group VI included animals that were implanted with carrier containing 10 μg rhBMP-2, followed by injections of PTH 1-34.

Kanezaki S., Miyazaki M., Ishihara T., Notani N., Abe T., Tsubouchi Y., Kataoka M, & Tsumura H. (2019). Enhancement of the effects of intermittent parathyroid hormone (1-34) by bone morphogenetic protein in a rat femoral open fracture model. Journal of Orthopaedic Surgery and Research, 14, 403.

+ Open protocol

+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!