The largest database of trusted experimental protocols

Sd rats

Manufactured by Koatech

SD rats are laboratory rodents used for research purposes. They are a widely used strain of rat in various scientific studies. SD rats have well-characterized biological and physiological properties, making them a valuable model for researchers.

Automatically generated - may contain errors

4 protocols using sd rats

1

Indomethacin-Induced Acute Stomach Injury in Rats

Check if the same lab product or an alternative is used in the 5 most similar protocols
Forty male SD rats were purchased from KOATECH (Gyeonggi-do, Korea). All animals were divided into four groups (n = 10 per group): control, indomethacin-induced acute stomach injury, positive control (AE), and experimental (ECC). All animals were maintained at 22 ± 2 °C with 55 ± 5% humidity and a 12/12 h light/dark cycle. Rats were fasted for 48 h, and then AE and ECC (10 mL/kg) were orally injected into animals in each group. The dose concentration was determined by referring to previous studies [1 (link)]. After 30 min, indomethacin (80 mg/kg) was orally administered to induce acute stomach injury. Five hours later, all animals were sacrificed under inhalation anesthesia with isoflurane, and their stomachs and serum were extracted for experiments. All diets and water were freely provided. This study was approved by the KNOTUS Institutional Animal Care and Use Committee (AEC-20120608-0001; Korea).
+ Open protocol
+ Expand
2

Urate-Lowering Therapy in Rats

Check if the same lab product or an alternative is used in the 5 most similar protocols
Either PAT101 (1.0 mg/kg) or rasburicase (0.325 mg/kg) was administrated into the caudal vein of 6-week-old male SD rats (KOATECH, Korea) (n = 5 per group) once a week for a total of 4 times and blood was collected at a scheduled time point.
+ Open protocol
+ Expand
3

Pharmacokinetic Study of Drugs Using Rat Liver S9 Fraction

Check if the same lab product or an alternative is used in the 5 most similar protocols
ACS/HPLC reagent-grade acetonitrile, methanol, and water were procured from Honeywell (Morristown, NJ, USA). HPLC-grade dimethyl sulfoxide (DMSO) and formic acid (FA) were procured from Junsei Chemical Co., Ltd. (Tokyo, Japan) and Dae-Jung Chemicals and Metals Co., Ltd. (Siheung, Republic of Korea). Buspirone (BUS), dextromethorphan (DEX), diclofenac (DIC), and alpelisib (IS) were procured from MedKoo Bioscience, Inc. (Morrisville, NC, USA). Magnesium Chloride (MgCl2), β-nicotinamide adenine dinucleotide 2′-phosphate reduced tetrasodium salt hydrate (NADPH), polyethylene glycol 400 (PEG400), and potassium phosphate buffer were procured from Sigma-Aldrich Co. (St. Louis, MO, USA). Sprague Dawley (SD) rat liver S9 fraction was procured from Sekisui Xenotech (Kansas City, KS, USA). SD rats (Male; nine-week-old; weighing range: 250–270 g) were supplied by Koatech Co. (Pyeongtaek, Republic of Korea). The SD rats were used for pharmacokinetic studies after an acclimation period of 7 days. Feeding, excluding water, was restricted for 12 h before starting the pharmacokinetics study. All animal studies were conducted with approval from the Institutional Animal Care and Use Committee of Pusan National University (approval number: PNU-2023-3245).
+ Open protocol
+ Expand
4

Dietary Impacts on Rat Metabolism

Check if the same lab product or an alternative is used in the 5 most similar protocols
4-week-old male SD rats (Koatech, Pyeongtaek, Korea) were housed in a temperature (23 ± 3°C) and humidity (55 ± 15%) controlled room with a ratio of 12-hour light/12-hour darkness, and were fed normal diet (Jongang Lab Animal, Seoul, Korea) for 1 week. Then, the animals were separately fed two kinds of diets, the normal diet and the high-fat diet for 6 weeks. The compositions of the normal diet and the high-fat diet which modified the AIN-76 dietary composition (Reeves et al., 1993 (link)), are shown in Supplemental Table 1.
+ Open protocol
+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required

Sign up now

Revolutionizing how scientists
search and build protocols!