Phenylbiguanide

Manufactured by Merck Group

Sourced in United States

Phenylbiguanide is a chemical compound used in various laboratory applications. It functions as a biguanide derivative. Further details on its specific uses or applications are not available.

Automatically generated - may contain errors

Lab products found in correlation

Potassium cyanide, by Merck Group (1 mentions) Escherichia coli lps, by Merck Group (1 mentions) Proguanil, by Merck Group (1 mentions) Phenformin, by Merck Group (1 mentions)

2 protocols using phenylbiguanide

Investigating Immune and Autonomic Responses

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Escherichia coli LPS [(1.5 or 2.5 mg kg⁻¹, 0111: B4 dissolved in pyrogenic-free saline [35 (link)]], potassium cyanide [KCN, 40 μg diluted in 0.05 mL of saline (Sal) [36 (link)]], and phenylbiguanide [(PBG, 5.0 μg kg⁻¹) [37 (link)]] were purchased from Sigma-Aldrich, USA.

Amorim M.R., de Deus J.L., Cazuza R.A., Mota C.M., da Silva L.E., Borges G.S., Batalhão M.E., Cárnio E.C, & Branco L.G. (2019). Neuroinflammation in the NTS is associated with changes in cardiovascular reflexes during systemic inflammation. Journal of Neuroinflammation, 16, 125.

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Biguanide Compound Screening Protocol

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Phenformin, phenyl biguanide (PubChem CID: 5932) (Sigma-Aldrich Ltd.), isopropyl biguanide (PubChem CID: 9570185), chloroPhenformin (PubChem CID: 67587204) (AKOS GmbH), and benzyl biguanide (PubChem CID: 9570091) (Angene International Ltd.) were added from aqueous stock solutions, and proguanil (Sigma-Aldrich Ltd.) and bis-isopropyl biguanide (PubChem CID: 23437065) (European Directorate for the Quality of Medicines and Healthcare) from stock solutions in DMSO.

Bridges H.R., Sirviö V.A., Agip A.N, & Hirst J. (2016). Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase. BMC Biology, 14, 65.

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