Trace mineral grade nitric acid

Manufactured by Thermo Fisher Scientific

Trace mineral grade nitric acid is a high-purity, concentrated nitric acid solution designed for trace metal analysis. It is used as a sample digestion and preparation reagent in analytical laboratories.

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Lab products found in correlation

Plasma quant ms elite, by Analytik Jena (1 mentions) Hydrochloric acid (hcl), by Thermo Fisher Scientific (1 mentions) Icp ms, by Analytik Jena (1 mentions)

Spelling variants of this product

Nitric acid (193 citations) Trace nitric acid (2 citations)

3 protocols using trace mineral grade nitric acid

Trace Metal Analysis of Samples

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Composition analysis was carried out at the Analytical Chemistry Services of the Iowa State University Veterinary Diagnostic Laboratory. Samples were analysed for copper and zinc content using an Inductively Coupled Plasma Mass Spectrometry (Plasma Quant MS Elite, Analytik Jena Inc. Woburn, MA, USA) in CRI mode with hydrogen as the skimmer gas. Standards were obtained from Inorganic Ventures (Christiansburg, VA). 15 mL centrifuge tubes and trace mineral grade nitric acid were purchased from Fisher Scientific (Pittsburgh, PA). Samples were partitioned into 15 mL tubes and digested in 70% nitric acid at 70 °C in a dry heat bath for 2 h. After digestion, samples were diluted using 1% nitric acid. Samples with elevated copper content occasionally needed an additional dilution made using 1% nitric acid and were analysed by ICP-MS after the dilution. For copper and zinc analysis, yttrium was used as internal standards for the ICP-MS analysis.

Pan C., Phadke K.S., Li Z., Ouyang G., Kim T.H., Zhou L., Slaughter J., Bellaire B., Ren S, & Cui J. (2022). Sprayable copper and copper–zinc nanowires inks for antiviral surface coating. RSC Advances, 12(10), 6093-6098.

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Elemental Analysis of Mouse Colon Samples

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Colon samples were carefully excised from mice designated for biochemical and neurochemical analyses and weighed prior to sample preparation. Samples were analyzed for cadmium (Cd), Ca, cromium (Cr), cobalt (Co), copper (Cu), iron (Fe), Mg, Mn, molybdenum (Mo), phosphorus (P), potassium (K), selenium (Se), sodium (Na), and zinc (Zn), using ICP-MS (Analytik Jena, Inc.) in CRI mode with hydrogen as the skimmer gas. Standards for elemental analyses were obtained from Inorganic Ventures, and digestion vessels, trace mineral grade nitric acid, and hydrochloric acid were obtained from Fisher Scientific. Briefly, samples were digested in 70% v/v nitric acid at 60°C for

\geq 12 h

. Preweighed samples were transferred to

15 -mL

tubes, and

0.25 mL

of 70% nitric acid was added. All samples were digested overnight at 60°C. After digestion, all samples were diluted to

5 mL

using 1% v/v nitric acid with 0.5% v/v hydrochloric acid and then analyzed by ICP-MS. For quality control, bismuth (Bi), scandium (Sc), indium (In), lithium (Li), yttrium (Y) and terbium (Tb) were used as internal standards for the ICP-MS.

Ghaisas S., Harischandra D.S., Palanisamy B., Proctor A., Jin H., Dutta S., Sarkar S., Langley M., Zenitsky G., Anantharam V., Kanthasamy A., Phillips G.J, & Kanthasamy A. (2021). Chronic Manganese Exposure and the Enteric Nervous System: An in Vitro and Mouse in Vivo Study. Environmental Health Perspectives, 129(8), 087005.

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Elemental Analysis of Microglial Cells

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Microglial cell line samples were carefully scraped and counted prior to
sample preparation. Samples were analyzed for different metals including, Cd,
Ca, Cr, Co, Cu, Fe, Mg, Mn, Mo, P, K, Se, Na, and Zn using ICP-MS (Analytik Jena
Inc. Woburn, MA, USA) in CRI mode with hydrogen as the skimmer gas. Standards
for elemental analyses were obtained from Inorganic Ventures (Christiansburg,
VA) and digestion vessels, trace mineral grade nitric acid and hydrochloric acid
were obtained from Fisher Scientific (Pittsburgh, PA). Briefly, samples were
digested in 70% nitric acid at 60˚C for ≥12 hours. Pre-weighed
samples were transferred to 15 mL tubes and 0.25 mL of 70% nitric acid was
added. All samples were digested overnight at 60˚C. After digestion, all
samples were diluted to 5 mL using 1% nitric acid with 0.5% hydrochloric acid
and then analyzed by ICP-MS. For quality control, Bi, Sc, In, Li, Y, and Tb were
used as internal standards for the ICP-MS.

Sarkar S., Rokad D., Malovic E., Luo J., Harischandra D.S., Jin H., Anantharam V., Huang X., Lewis M., Kanthasamy A, & Kanthasamy A.G. (2019). Manganese Activates NLRP3 Inflammasome Signaling and Propagates Exosomal Release of ASC in Microglial Cells. Science signaling, 12(563), eaat9900.

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