Tim trio mri scanner

Imaging consisted of structural MRI and two different positron emission tomography (PET) imaging sessions: 1) amyloid imaging with [¹¹C]PIB and 2) quantitative cerebral blood flow imaging with [¹⁵O]water (with arterial blood sampling) under 3 conditions (counting task, list remembering task, rest task (eyes open, ears unplugged). All PET imaging was performed on a Siemens ECAT EXACT HR+ with transmission imaging ([⁶⁸Ge]) for attenuation correction performed prior to the injection of the radiotracers. MR imaging was performed on a 3.0T Siemens TIM Trio MRI Scanner or on a GE 750W 3T scanner. All image analyses were performed using the PMOD suite of tools (PVIEW, PFUSION, PNEURO, PXMOD, PKIN, PALZ, v. 3.7 and 3.8, PMOD Technologies, Ltd, Zurich, Switzerland).

Structural MRI was acquired as volumetric sagittal T1 MP-RAGE (TI=900ms, TE=3.2ms, TR=8.5ms, flip angle=8°, FOV=256×256×192mm, matrix=256×256×192, bandwidth= 250Hz/pixel, acceleration=2) on a 3.0T Siemens TIM Trio MRI Scanner or on a GE 750W 3T scanner.