All participants underwent fMRI scanning with a 3.0T MRI scanner (Achieva, Philips Medical System, Best, Netherlands) to obtain T2*-weighted single-shot echo-planar imaging sequences with the following parameters: 165 axial volume scans: voxel size, 2.75 × 2.75 × 3.0 mm
3; slice number, 31 (interleaved); matrix, 80 × 80; slice thickness, 3.0 mm; gap, 1.0 mm; repetition time (TR), 2000 ms; echo time (TE), 30 ms; and field of view (FOV), 220 mm. Subjects were instructed to rest and keep their eyes closed without sleeping, moving, or thinking about anything specific for 5 min 30 s.
A 3D-T1-turbo field echo sequence was also obtained with the following parameters: axial acquisition with FOV, 220 mm; voxel size, 0.98 × 0.98 × 1.2 mm
3; TR, 9.6 ms; TE, 4.6 ms; flip angle, 8°; no gap; and total acquisition time, 5 min 29.3 s.
DAT scans were performed with a
GE PET-CT DSTe scanner (GE Discovery STE, GE Healthcare Technologies, Milwaukee, WI), which obtained images with a 3D-resolution of 2.3 mm thickness at half-maximum. All participants fasted for at least 6 h before DAT scanning. Each patient received 5 mCi (185 MBq) of 18F-FP-CIT intravenous injection, and images were acquired in the 3D mode at 120 KVp and 380 mAs during a 20-min session that took place 90 min after each injection.
Oh S.W., Shin N.Y., Yoon U., Sin I, & Lee S.K. (2020). Shared functional neural substrates in Parkinson's disease and drug-induced parkinsonism: association with dopaminergic depletion. Scientific Reports, 10, 11617.