Nicotine salt ditartrate dihydrate

Manufactured by Thermo Fisher Scientific

Nicotine salt (ditartrate dihydrate) is a lab equipment product. It is a chemical compound that serves as a source of nicotine for various research and analytical applications.

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Lab products found in correlation

Menthol, by Thermo Fisher Scientific (2 mentions) Methylbutyl acetate, by Tokyo Chemical Industry (1 mentions) Ethyl acetate, by Chem-Impex (1 mentions) Hexyl acetate, by Tokyo Chemical Industry (1 mentions) Propylene glycol, by Tedia (1 mentions)

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Nicotine ditartrate dihydrate (7 citations) Nicotine (5 citations) (ditartrate dihydrate (2 citations)

2 protocols using nicotine salt ditartrate dihydrate

E-Liquid Flavor and Nicotine Preparation

Cited 2 times

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Hexyl acetate (catalog #A0032) and methylbutyl acetate (catalog #A1076) were obtained from TCI Chemicals, ethyl acetate was obtained from Chem-Impex International (catalog #00757), nicotine salt (ditartrate dihydrate) was obtained from Acros Organics (catalog #AC415660500), (-)-menthol was obtained from Alfa Aesar (catalog #A10474), dihydro-β-erythroidine (DhβE) hydrobromide was purchased from ApexBio (catalog #B7030), propylene glycol was obtained from Tedia (catalog# PR1494-065), and vegetable glycerin was obtained from J.T. Baker (catalog #2143-01). All e-liquids were mixed with the vehicle, propylene glycol and vegetable glycerin (PGVG; 50:50 ratio), at a final concentration of 15 mg/ml for flavor (GA-mix, Hexyl acetate, ethyl acetate, or methylbutyl acetate) and 6 mg/ml nicotine (menthol plus nicotine e-liquids only). For GA-mix we used Hexyl acetate, ethyl acetate, and methylbutyl acetate (3:1:1, respectively) following analytical investigations into commercial e-liquids (Tierney et al., 2016 (link); Omaiye et al., 2019 (link)).

Cooper S.Y., Willis C.V., Richardson M.R., Hill S.P., Wright S.K., Elmore M.B., Mitchell Z.B., González Castro A.K, & Henderson B.J. (2023). Chemical Flavorants in Vaping Products Alter Neurobiology in a Sex-Dependent Manner to Promote Vaping-Related Behaviors. The Journal of Neuroscience, 43(8), 1360-1374.

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Nicotine-Menthol E-Liquid Formulation

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(−)-nicotine (N2472–100ML, lot#: 2AH0278) was obtained from Spectrum. Nicotine-salt (ditartrate dihydrate) was obtained from Acros Organics (AC415660500). (−)-menthol was obtained from Alfa Aesar (A10474). Both nicotine formulations were mixed with propylene glycol and vegetable glycerin (PGVG) at a 50:50 ratio at a final concentration of 6 mg/mL. This dose was selected based on our previous investigation [11 ]. For both formulations, nicotine content was based upon molecular weight of freebase to ensure equal amounts of nicotine were present.

Henderson B.J, & Cooper S.Y. (2021). Nicotine formulations impact reinforcement-related behaviors in a mouse model of vapor self-administration. Drug and alcohol dependence, 224, 108732.

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