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Sprague dawley cd igs rats

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The Sprague-Dawley CD (IGS) rats are a widely used outbred rat strain. They are known for their calm temperament and suitability for a variety of research applications.

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Nih 07 diet, by LabDiet (1 mentions)

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Sprague-Dawley rats (3110 citations) Sprague-Dawley (76 citations) CD Sprague Dawley rats (16 citations) CD (Sprague Dawley) IGS rats (7 citations) CD IGS rats (4 citations) ) IGS rats (3 citations) Male Sprague-Dawley CD IGS rats (3 citations) CD-Sprague-Dawley (2 citations) CRL Sprague-Dawley CD® IGS rats (2 citations)

5 protocols using sprague dawley cd igs rats

1

Sprague-Dawley Rat Breeding Protocol

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Male sires and nulliparous female Sprague–Dawley CD (IGS) rats (Charles River Laboratories, Raleigh, NC, strain #001) were habituated for at least one week in the vivarium (AAALAC-accredited) prior to breeding. Animals were maintained on a 14:10 h light:dark cycle (lights on at 600 h) with controlled temperature (19 ± 1 °C) and humidity (50% ± 10%). Animals were housed in a barrier using the Modular Animal Caging System (Alternative Design, Siloam Spring, AR). HEPA filtered air was supplied to cages directly (Alternative Design, Siloam Spring, AR) at 30 air changes/h. Water was provided to each cage using an automated system (SE Lab Group, Napa, CA); NIH-07 diet was provided ad libitum except during the FeD feeding period. A curved stainless steel enclosure was placed in each cage as enrichment [71] (link). Following cohabitation, detection of a sperm plug counted as E0. Birth was designated as P0 and offspring were weaned at P28 [10] , [57] (link).
Amos-Kroohs R.M., Bloor C.P., Qureshi M.A., Vorhees C.V, & Williams M.T. (2015). Effects of developmental exposure to manganese and/or low iron diet: Changes to metal transporters, sucrose preference, elevated zero-maze, open-field, and locomotion in response to fenfluramine, amphetamine, and MK-801. Toxicology Reports, 2, 1046-1056.
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2

Sprague-Dawley Rat Breeding and Weaning

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Male sires and nulliparous female Sprague-Dawley CD (IGS) rats (Charles River Laboratories, Raleigh, NC, strain #001) were habituated for at least one week in the vivarium (AAALAC-accredited) prior to breeding. Animals were maintained on a 14:10 h light:dark cycle (lights on at 600 h) with controlled temperature (19 ± 1 °C) and humidity (50% ± 10%). Animals were housed in a barrier using the Modular Animal Caging System (Alternative Design, Siloam Spring, AR). HEPA filtered air was supplied to cages directly (Alternative Design, Siloam Spring, AR) at 30 air changes/h. Water was provided to each cage using an automated system (SE Lab Group, Napa, CA); NIH-07 diet was provided ad libitum except during the FeD feeding period. A curved stainless steel enclosure was placed in each cage as enrichment (Vorhees et al., 2008 (link)). Following cohabitation, detection of a sperm plug counted as E0. Birth was designated as P0 and offspring were weaned at P28 (Blass and Teicher, 1980 (link); Redman and Sweney, 1976 (link)).
Amos-Kroohs R.M., Bloor C.P., Qureshi M.A., Vorhees C.V, & Williams M.T. (2015). Effects of developmental exposure to manganese and/or low iron diet: Changes to metal transporters, sucrose preference, elevated zero-maze, open-field, and locomotion in response to fenfluramine, amphetamine, and MK-801. Toxicology Reports, 2, 1046-1056.
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3

Sprague-Dawley Rat Breeding and Culling Protocol

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Male and nulliparous female (175–200 g when received) Sprague-Dawley CD/IGS rats (strain 001) were obtained from Charles River Laboratories, Raleigh, NC and acclimated for not less than one week before breeding. Rats were maintained in an AAALAC International accredited vivarium on a 14:10 h light-dark cycle (lights on at 600 h) with controlled temperature (19 ± 1 °C) and humidity (50 ± 10%). Rats were provided with ad lib NIH-07 diet (LabDiet, Richmond, IN) and reverse osmosis, UV filtered water. An adult male and female were housed together until the morning a sperm plug was found (embryonic day (E)0). On E1 females were housed individually in polycarbonate cages (26 cm × 48 cm and 20 cm tall) containing woodchip bedding and a semicircular stainless steel enclosure as environmental enrichment (Vorhees, C. V. et al., 2008 (link)). Parturition was designated postnatal day (P)0 and on P1 litters were briefly removed, weighed, sexed, and using a random number table, 4 males and 4 females were retained and the rest culled. If a litter had too few of one sex and another litter had extra pups born within 24 h, 1–2 pups were in-fostered to the litter with too few of one sex. Weaning was on P28 at which time same sex pairs from each litter were housed together (2/cage).
Sprowles J.L., Vorhees C.V, & Williams M.T. (2021). Impact of preweaning stress on long-term neurobehavioral outcomes in Sprague-Dawley rats: differential effects of barren cage rearing, pup isolation, and the combination. Neurotoxicology and teratology, 84, 106956.
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Sprague-Dawley Rat Breeding and Rearing Protocol

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Nulliparous female Sprague-Dawley CD (IGS) rats (Charles River Laboratories, Raleigh, NC; strain #001), approximately 60 days old on arrival were habituated for not less than one week to the vivarium (AAALAC International accredited) before breeding by being placed with male sires of the same strain and supplier. Animals were maintained on a 14-10 h light-dark cycle (lights on 600 h) with controlled temperature (19 ± 1°C) and humidity (50% ± 10%). Animals were housed in a barrier facility using a Modular Caging System (Alternative Design, Siloam Spring, AR). HEPA filtered air was supplied to each cage (Alternative Design, Siloam Spring, AR) with 30 air changes/h. Reverse osmosis filtered water (SE Lab Group, Napa, CA) and NIH-07 diet were provided ad libitum. A semicircular stainless steel enclosure was placed in standard cages for enrichment (Vorhees et al., 2008 (link)). Females were separated the day a sperm plug was detected and this day was designated E0. Birth was counted as postnatal day P0; on P1, litters were culled to 10, five per sex, using a random number table. Pups were removed from dams on P28 into same sex cages (4/cage) and re-housed (2/cage) on P42. Maternal body weight was measured on E7, 15, 21, and P1 and 28. Pups were weighed on P1, during dosing and on P42 and P60.
Amos-Kroohs R.M., Davenport L.L., Atanasova N., Abdulla Z.I., Skelton M.R., Vorhees C.V, & Williams M.T. (2016). Developmental Manganese Neurotoxicity in Rats: Cognitive Deficits in Allocentric and Egocentric Learning and Memory. Neurotoxicology and teratology, 59, 16-26.
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5

Sprague Dawley CD IGS Rat Study

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Twenty-nine (n = 29) P16–18 infant male Sprague Dawley CD IGS rats (Charles River Laboratoires Italia, Calco, Italy) were used in this study. Animals were treated in accordance with the European Community Directives 86/609/EEC and 2010/63/EU, and the 3R concept has been considered when planning the experiments. The animal study protocol was approved by the Ethical Committee of the University of Bologna. Rats were individually housed under controlled conditions (temperature: 24 ± 1 °C; humidity: 50 ± 5%), maintained on a 12:12 h light-dark cycle, and fed ad libitum.
Zironi I, & Aicardi G. (2022). Hypoxia Depresses Synaptic Transmission in the Primary Motor Cortex of the Infant Rat—Role of Adenosine A1 Receptors and Nitric Oxide. Biomedicines, 10(11), 2875.
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