Phenacetin, bupropion, tolbutamide, dextromethorphan, midazolam, chlorzoxazone, and the diazepam (all purity> 98%) that used as internal standards (ISs) were purchased from J&K Scientific Ltd. (Beijing, China). Vonoprazan was purchased from Beijing Sunflower Scientific Ltd. (Beijing, China). Hydroxybupropion and hydroxymidazolam were purchased from Sigma-Aldrich (St Louis, USA). Dextrorphan, hydroxytolbutamide, hydroxychlorzoxazone, and 4-acetamidophenol were purchased from Toronto Research Chemicals (Toronto, Canada). Reduced nicotinamide adenine dinucleotide phosphate (NADPH) was acquired from Roche Pharmaceuticals Ltd. (Basel, Switzerland). Ultra-pure water was produced by Milli-Q, a reagent-standard water purification system (Millipore, Bedford, USA). Acetonitrile and methanol that of high performance liquid chromatography (HPLC) grade were obtained from Merck Company (Darmstadt, Germany).
Midazolam
Manufactured by J&K Scientific
Sourced in China, Hong Kong
Midazolam is a benzodiazepine medication commonly used as a sedative or anxiolytic in clinical settings. It is a short-acting drug that can be administered intravenously, intramuscularly, or orally. Midazolam works by enhancing the effects of gamma-aminobutyric acid (GABA) in the brain, which can lead to a calming effect and reduced anxiety. This product is typically used for procedural sedation, general anesthesia induction, and the treatment of certain types of seizures.
Automatically generated - may contain errors
Lab products found in correlation
Acetonitrile, by Merck Group (2 mentions)
Methanol, by Merck Group (2 mentions)
Diazepam, by J&K Scientific (1 mentions)
Hydroxybupropion, by Merck Group (1 mentions)
Hydroxytolbutamide, by LGC (1 mentions)
Tolbutamide, by J&K Scientific (1 mentions)
Dextrorphan, by LGC (1 mentions)
Milli q, by Merck Group (1 mentions)
Phenacetin, by J&K Scientific (1 mentions)
Chlorzoxazone, by J&K Scientific (1 mentions)
4 acetamidophenol, by LGC (1 mentions)
Nadph na4, by Roche (1 mentions)
2 protocols using midazolam
1
Analytical Method for Xenobiotic Metabolism
2
Quantitative Analysis of Sildenafil and Metabolite
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Sildenafil (purity 99.0%), its metabolite N-desmethyl sildenafil (purity 99.0%), and the Internal Standard (IS) Midazolam (over 99% purity) were purchased from J&K Scientific Ltd. (Hong Kong, China). The NADPH-Na4 was bought from Roche (Basel, Switzerland). Wild-type and recombinant human cytochrome P450 microsomes (CYP2C9 and CYP3A4) and CYP b5 expressed in insect baculovirus expression system were acquired from Beijing Hospital (Beijing, China). We got mass spectrometry analytical–grade methanol, acetonitrile and other organic solvents from Merck (Darmstadt, Germany). The ultrapure water was gained via Merck Millipore Milli-Q Advantage 10 system (Billerica, MA, USA). All other materials and reagents used were acquired from Sunflower and Technology Ltd. (Beijing, China). Spodoptera frugiperda (Sf)21 insect cells were purchased from Invitrogen (Carlsbad, CA, USA).
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