Rosuvastatin

Manufactured by LGC

Sourced in United States, Canada

Rosuvastatin is a laboratory product that functions as a key analytical tool in various research and testing applications. It serves as a reference standard for the quantitative analysis of pharmaceutical and biological samples. This product enables precise measurements and accurate characterization of the target analyte, supporting the development and quality control of drugs and other related substances.

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Lab products found in correlation

3 protocols using rosuvastatin

Statin Drugs and Cholesterol Synthesis

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Nine statin drugs were obtained from commercial sources: Atorvastatin calcium salt trihydrate, simvastatin, pravastatin, mevastatin (PZ0001, S6196, P4498, M2537 Sigma, St Louis, MO, USA); fluvastatin, rosuvastatin, cerivastatin (F601250, R700500, C277000, Toronto Research Chemicals Inc., Toronto, ON, Canada); pitavastatin (S1759, Selleckchem, Boston, MA, USA); lovastatin (430-103-M050, Enzo life sciences, Farmingdale, NY, USA). We prepared 10 mM stock solution in DMSO for in vitro testing. For in vivo testing, pitavastatin was prepared as fresh suspension in methycellulose at 0.4 mg ml⁻¹ (for oral gavage). fluvastatin, cerivastatin, and pitavastatin were prepared as a solution at 0.25 mg ml⁻¹ in PBS for IP injection. GGTI-298 and FTI-277 (G5169, A1393, Sigma) were made into 10 mM stock solution in DMSO. AICAR (#S1802, Selleckchem) was made into 100 mM stock solution in PBS. Intermediate products of cholesterol synthesis were purchased from Sigma: mevalonolactone (M4667), farnesyl pyrophosphate ammonium salt (F6892), geranylgeranyl pyrophosphate ammonium salt (G6025), squalene (S3626), cholesterol solution (S5442), geranylpyrophosphate (G6772), and isopentenyl pyrophosphate triammonium salt solution (I0503).

Jiang P., Mukthavaram R., Chao Y., Nomura N., Bharati I.S., Fogal V., Pastorino S., Teng D., Cong X., Pingle S.C., Kapoor S., Shetty K., Aggrawal A., Vali S., Abbasi T., Chien S, & Kesari S. (2014). In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells. British Journal of Cancer, 111(8), 1562-1571.

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Targeted Steroid and Metabolite Analysis

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Rosuvastatin, d5-estrone sulfate, d5-DHEAS, ¹⁵N₄-CPI, d8-CPIII and d6-Rosuvastatin were purchased from Toronto Research Chemicals (Toronto, ON, Canada). CPI and CPIII were obtained from Frontier Specialty Chemicals (Logan, UT, United States). All other chemicals, unless otherwise stated, were obtained from Sigma-Aldrich (St. Louis, MO).

Medwid S., Price H.R., Taylor D.P., Mailloux J., Schwarz U.I., Kim R.B, & Tirona R.G. (2021). Organic Anion Transporting Polypeptide 2B1 (OATP2B1) Genetic Variants: In Vitro Functional Characterization and Association With Circulating Concentrations of Endogenous Substrates. Frontiers in Pharmacology, 12, 713567.

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Radiolabeled Compound Synthesis and Characterization

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[ 3 H]-fexofenadine (78 Ci/mmol, 99.7% radiochemical purity) was custom synthesized by Quotient Bioresearch (Fordham, Cambridgeshire, UK) by nonspecific labeling. [ 3 H]-rosuvastatin (5 mCi/mmol, 99% radiochemical purity) was purchased from American Radiolabeled Chemicals (St. Louis, MO). [ 3 H]bromosulfophthalein (10.6 Ci/mmol, 99.5% radiochemical purity) was obtained from Moravek (Brea, CA). [ 3 H]-estrone-3-sulfate (54.3 Ci/mmol, .97% radiochemical purity) was purchased from PerkinElmer (Woodbridge, ON, Canada). Unlabeled fexofenadine, d6-fexofenadine, rosuvastatin, and d6-rosuvastatin were purchased from Toronto Research Chemicals (Toronto, ON). Concentrated (4Â) GFJ (Minute Maid, 100% grapefruit juice frozen concentrate) and concentrated (4Â) AJ (no name, apple juice, frozen concentrate) were acquired from Walmart (London, ON) and Real Canadian Superstore (London, ON), respectively. The same GFJ and AJ stocks were used for all fruit juice experiments. All other chemicals, unless otherwise stated, were obtained from Sigma-Aldrich (St. Louis, MO).

Medwid S., Li M.M.J., Knauer M.J., Lin K., Mansell S.E., Schmerk C.L., Zhu C., Griffin K.E., Yousif M.D., Dresser G.K., Schwarz U.I., Kim R.B, & Tirona R.G. (2019). Fexofenadine and Rosuvastatin Pharmacokinetics in Mice with Targeted Disruption of Organic Anion Transporting Polypeptide 2B1. Drug metabolism and disposition: the biological fate of chemicals, 47(8).

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