Before the mice were sacrificed for evaluating the treatment effect of MBZ-OS against secondary cysts of E. granulosus, the blood sera of 10 mice respectively from MBZ-OS and MBZ-1% trangacanth at a dose of 25 mg/kg, and untreated control group were collected and immediately ready for the liver function test. In order to observe the liver injury of mice infected with E. granulosus cysts, the blood of normal mice, which were kept for the same 8 months was also collected and served as uninfected group. The liver function test was carried out by Adicon Clinical Laboratories (Shanghai, China) with Automatic Chemistry Analyzer 640 (OLYMPUS, Japan). The total protein (TP), albumin (ALB), globulin (GLB), total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate transaminase (AST) were analyzed with Automatic Chemistry Analyzer 640 (Olympus, Japan).
Liu C.S., Zhang H.B., Lei W., Zhang C.W., Jiang B., Zheng Q., Yin J.H, & Han X.M. (2014). An alternative mebendazole formulation for cystic echinococcosis: the treatment efficacy, pharmacokinetics and safety in mice. Parasites & Vectors, 7, 589.
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