Signa 1.5 t machine

PET imaging was performed using an Eminence STARGATE PET scanner (Shimadzu). After intravenous injection of 18 F-THK5351 (185 MBq) or 11 C-PiB (296 MBq), dynamic PET images were obtained for 60 min ( 18 F-THK5351) or 70 min ( 11 C-PiB) with the patient's eyes closed. T1-weighted MR images were obtained with a SIGNA 1.5-T machine (GE Healthcare) using a previously described method (4). SUV images of 18 F-THK5351 (40-60 min after injection) and 11 C-PiB (50-70 min after injection) were obtained by normalizing tissue radioactivity concentration by injected dose and body weight. The regional SUV-to-cerebellar cortex SUV ratio (SUVR) was used as an index of tracer retention. PET images were coregistered on MR images using SPM12 software (SPM12; Wellcome Department of Imaging Neuroscience, UCL). Regions of interest were drawn on the coregistered MR image using PMOD software (version 3.7; PMOD Technologies GmbH).

PET imaging was performed using an Eminence STARGATE PET scanner (Shimadzu). After intravenous injection of 18 F-THK5117 (185 MBq), 18 F-THK5351 (185 MBq), or 11 C-PiB (296 MBq), dynamic PET images were obtained for 90 min ( 18 F-THK5117 and 18 F-THK5351) or 70 min ( 11 C-PiB), with the patients' eyes closed. MRI was performed on all participants. T1-and T2-weighted MR images were obtained using a SIGNA 1.5-T machine (GE Healthcare). In T1-weighted MRI, a 3-dimensional volumetric acquisition of a T1weighted gradient echo sequence produced a gapless series of thin axial sections using a vascular time-of-flight spoiled gradient recalled echo sequence (echo time/repetition time, 2.4/50 ms; flip angle, 45°; acquisition matrix, 256 • 256; 1 excitation; field of view, 22 cm; slice thickness, 2.0 mm).