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Anti c iap1

Manufactured by Enzo Life Sciences
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Anti-c-IAP1 is a laboratory reagent that binds to and inhibits the activity of the cellular inhibitor of apoptosis protein 1 (c-IAP1). c-IAP1 is a protein involved in regulating cell survival and programmed cell death (apoptosis). The Anti-c-IAP1 reagent can be used in research studies to investigate the role of c-IAP1 in cellular processes.

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Lab products found in correlation

Anti β actin, by Merck Group (2 mentions) Anti p100 p52, by Merck Group (2 mentions) Anti erk, by Cell Signaling Technology (2 mentions) Anti phospho erk, by Cell Signaling Technology (2 mentions) Z vad fmk, by Cayman Chemical (2 mentions) Birinapant, by Chemietek (2 mentions) Anti ciap2, by Cell Signaling Technology (2 mentions) Sp600125, by Selleck Chemicals (2 mentions) Trametinib, by LC Laboratories (2 mentions) Mouse anti gapdh, by Merck Group (1 mentions) Doxorubicin, by Merck Group (1 mentions) Cisplatin, by Merck Group (1 mentions) Murine tnf α, by Thermo Fisher Scientific (1 mentions) Strail apo2l, by Thermo Fisher Scientific (1 mentions) Anti tnfr1, by Abcam (1 mentions) Anti fadd, by Abcam (1 mentions) Rabbit anti mouse hrp conjugated antibody, by Merck Group (1 mentions) Birinapant, by Apexbio (1 mentions) Anti ripk1, by BD (1 mentions) Anti caspase 3, by BD (1 mentions)

3 protocols using anti c iap1

1

Antibody and Compound Usage in Study

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The following primary antibodies and materials were used in this study: anti-p100/p52 (Millipore); anti-c-IAP1 (Enzo Life Sciences, Farmingdale, NY, USA); anti-c-IAP2 (Cell Signaling, Danvers, MA, USA); anti-GST, anti-p65, and anti-RelB (Santa Cruz Biotechnology, San Diego, CA, USA); anti-phospho-JNK, anti-JNK, anti-phospho-ERK, and anti-ERK (Cell Signaling); anti-β-actin (Sigma-Aldrich, St. Louis, MO, USA); Birinapant (ChemieTek, Indianapolis, IN, USA); Enbrel (University of Michigan Hospital pharmacy); z-VAD-fmk (Cayman Chemical, Ann Arbor, MI, USA); Trametinib (LC Laboratories, Woburn, MA, USA); and SP600125 (SelleckChem, Houston, TX, USA). The Smac mimetic SM-164 (37 (link)) was a kind gift from Dr. Shaomeng Wang (University of Michigan).
Kocab A.J., Veloso A., Paulsen M.T., Ljungman M, & Duckett C.S. (2015). Effects of Physiological and Synthetic IAP Antagonism on c-IAP-Dependent Signaling. Oncogene, 34(43), 5472-5481.
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2

Antibody and Compound Usage in Study

Check if the same lab product or an alternative is used in the 5 most similar protocols
The following primary antibodies and materials were used in this study: anti-p100/p52 (Millipore); anti-c-IAP1 (Enzo Life Sciences, Farmingdale, NY, USA); anti-c-IAP2 (Cell Signaling, Danvers, MA, USA); anti-GST, anti-p65, and anti-RelB (Santa Cruz Biotechnology, San Diego, CA, USA); anti-phospho-JNK, anti-JNK, anti-phospho-ERK, and anti-ERK (Cell Signaling); anti-β-actin (Sigma-Aldrich, St. Louis, MO, USA); Birinapant (ChemieTek, Indianapolis, IN, USA); Enbrel (University of Michigan Hospital pharmacy); z-VAD-fmk (Cayman Chemical, Ann Arbor, MI, USA); Trametinib (LC Laboratories, Woburn, MA, USA); and SP600125 (SelleckChem, Houston, TX, USA). The Smac mimetic SM-164 (37 (link)) was a kind gift from Dr. Shaomeng Wang (University of Michigan).
Kocab A.J., Veloso A., Paulsen M.T., Ljungman M, & Duckett C.S. (2015). Effects of Physiological and Synthetic IAP Antagonism on c-IAP-Dependent Signaling. Oncogene, 34(43), 5472-5481.
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3

Apoptosis-Inducing Agents and Antagonists

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Drugs used in this study were recombinant murine sTRAIL/Apo2L (Peprotech; NJ, USA), murine TNFα (Peprotech), Debio1143/AT-406 (Selleck Chemicals; Texas, USA), LCL161 (Selleck Chemicals), SM-164 (ApexBio; Texas, USA), Birinapant (ApexBio), BV6 (ApexBio), GDC-0512 (Selleck), doxorubicin (Sigma-Aldrich; MO, USA) and cisplatin (Sigma-Aldrich). The following antibodies were used: anti-cIAP1 (Enzo Life sciences; NY, USA), anti-cIAP2 (R&D systems; MN, USA), anti-XIAP (MBL International; MA, USA), anti-FADD (Abcam; Cambridge, UK), anti-TNFR1 (Abcam), anti-TRAIL-R2 (R&D systems), anti-caspase-3 (BD Biosciences; NJ, USA), anti-caspase-8 (Abcam), anti-RIPK1 (BD Biosciences), anti-RIPK3 (ProSci; CA, USA), anti-MLKL1 (Abcam), anti-phosphoS345-MLKL (Abcam), anti-CYLD (Thermo Fisher Scientific; Massachusetts, USA), anti-crmA (Santa Cruz Biotechnology; Texas, USA), rabbit anti-GFP (polyclonal in-house antibody), goat anti-rabbit FITC (Merck Millipore; MA, USA), rabbit anti-goat-FITC (Thermo Fisher Scientific), mouse anti-GAPDH (Merck Millipore), donkey anti-rabbit HRP conjugated antibody (GE Healthcare Life Sciences; NJ, USA), goat anti-rat HRP conjugated antibody (GE Healthcare Life Sciences), and rabbit anti-mouse-HRP conjugated antibody (Sigma).
Shekhar T.M., Miles M.A., Gupte A., Taylor S., Tascone B., Walkley C.R, & Hawkins C.J. (2016). IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα. Oncotarget, 7(23), 33866-33886.
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