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Dioctanoyl phosphatidylinositol 4 5 bisphosphate dic8 pip2

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Dioctanoyl phosphatidylinositol 4,5-bisphosphate (dic8-PIP2) is a synthetic analogue of the naturally occurring phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2). It serves as a research tool for the study of cellular signaling pathways involving PIP2.

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Lab products found in correlation

U73122, by R&D Systems (5 mentions) Bisindolylmaleimide 2 bis 2, by R&D Systems (5 mentions) Thapsigargin, by R&D Systems (5 mentions) Picrotoxin, by R&D Systems (5 mentions) Chelerythrine, by R&D Systems (5 mentions) Heparin, by R&D Systems (5 mentions) Gdp β s, by R&D Systems (4 mentions) U73343, by R&D Systems (4 mentions) Kynurenic acid, by R&D Systems (4 mentions) Tertiapin q, by R&D Systems (3 mentions) Sr49059, by R&D Systems (3 mentions) Ml 133, by R&D Systems (3 mentions) Ml 297, by R&D Systems (3 mentions) Capsazepine, by R&D Systems (2 mentions) Sr 48692, by R&D Systems (1 mentions) Tertiapin lq, by R&D Systems (1 mentions) Bapta, by R&D Systems (1 mentions) Kb r7943, by R&D Systems (1 mentions) Capsaicin, by R&D Systems (1 mentions) Sch23390, by R&D Systems (1 mentions)

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DiC8-PIP2 (11 citations)

5 protocols using dioctanoyl phosphatidylinositol 4 5 bisphosphate dic8 pip2

1

Neurochemical Modulation of Neuronal Excitability

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The following chemicals were products of R&D Systems: NT, TTX, kynurenic acid, picrotoxin, SR 48692, GDP-β-S, U73122, U73343, heparin, thapsigargin, chelerythrine, bisindolylmaleimide II (Bis II), ML 133, and tertiapin-Q (TQ). Dioctanoyl phosphatidylinositol 4,5-bisphosphate (dic8-PIP2) was purchased from Echelon Biosciences. PD149163 was product of Millipore Sigma. Drugs were initially prepared in stock solution, aliquoted and stored at −20°C. For those chemicals requiring dimethyl sulfoxide (DMSO) as a solvent, the concentration of DMSO was less than 0.1%. This concentration of DMSO either in the recording pipettes or in the bath had no significant effects on NT-elicited facilitation of AP firing (data not shown).
Lei S, & Hu B. (2021). Ionic and Signaling Mechanisms Involved in Neurotensin-mediated Excitation of Central Amygdala Neurons. Neuropharmacology, 196, 108714.
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2

Pharmacological Reagents for Neuronal Research

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The following chemicals were products of R&D Systems: AVP, TTX, kynurenic acid, picrotoxin, 6,7-dinitroquinoxaline-2,3-dione (DNQX), SR49059, GDP-β-S, U73122, U73343, heparin, thapsigargin, chelerythrine, bisindolylmaleimide II (Bis II), ML 133, ML 297, tertiapin-Q and tertiapin-LQ. Dioctanoyl phosphatidylinositol 4,5-bisphosphate (dic8-PIP2) was purchased from Echelon Biosciences. Drugs were initially prepared in stock solution, aliquoted and stored at −20°C. For those chemicals requiring dimethyl sulfoxide (DMSO) as a solvent, the concentration of DMSO was less than 0.1%. This concentration of DMSO either in the recording pipettes or in the bath had no significant effects on neuronal activity.
Hu B., Boyle C.A, & Lei S. (2021). Roles of PLCβ, PIP2 and GIRK Channels in Arginine Vasopressin-elicited Excitation of CA1 Pyramidal Neurons. Journal of cellular physiology, 237(1), 660-674.
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3

Pharmacological Toolbox for Neuronal Studies

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[Arg8]-vasopressin (AVP) was purchased from Bachem. The following chemicals were products of R&D Systems: TTX, kynurenic acid, picrotoxin, SR49059, GDP-β-S, U73122, U73343, heparin, thapsigargin, BAPTA, chelerythrine, bisindolylmaleimide II (Bis II), capsazepine, M084, edelfosine and pyrazolo[1,5-a]pyrimidin-7(4H)-on (QO-58). Dioctanoyl phosphatidylinositol 4,5-bisphosphate (diC8-PIP2) was purchased from Echelon Biosciences. Drugs were initially prepared in stock solution, aliquoted and stored at −20°C. For those chemicals requiring dimethyl sulfoxide (DMSO) as a solvent, the concentration of DMSO was less than 0.1%. This concentration of DMSO either in the recording pipettes or in the bath had no significant effects on neuronal activity.
Boyle C.A., Hu B., Quaintance K.L, & Lei S. (2021). Involvement of TRPC5 Channels, Inwardly Rectifying K+ channels, PLCβ and PIP2 in Vasopressin-mediated Excitation of Medial Central Amygdala Neurons. The Journal of physiology, 599(12), 3101-3119.
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4

Detailed Chemical Source Protocol

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The following chemicals were products of R&D Systems: senktide, TTX, picrotoxin, SB218795, ML133, glibenclamide, tertiapin-Q, ML297, M084, U73122, heparin, thapsigargin, chelerythrine and bisindolylmaleimide II (Bis II). Dioctanoyl phosphatidylinositol 4,5-bisphosphate (dic8-PIP2) was purchased from Echelon Biosciences. The other chemicals were the products of Sigma Aldrich. Drugs were initially prepared in stock solution, aliquoted and stored at −20°C. For those chemicals requiring dimethyl sulfoxide (DMSO) as a solvent, the concentration of DMSO was less than 0.1%.
Boyle C.A., Hu B., Quaintance K.L., Mastrud M.R, & Lei S. (2022). Ionic signaling mechanisms involved in neurokinin-3 receptor-mediated augmentation of fear-potentiated startle response in the basolateral amygdala. The Journal of physiology, 600(19), 4325-4345.
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5

Pharmacological Agents in Neuronal Signaling

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The following chemicals were products of R&D Systems: AVP, tetrodotoxin (TTX), kynurenic acid, picrotoxin, SR49059, TASP0390325, tolvaptan, GDP-β-S, U73122, U73343, heparin, thapsigargin, chelerythrine, bisindolylmaleimide II (Bis II), KB-R7943, capsazepine, AMG9810, AMG1629, capsaicin, ML 133, ML 297 and SCH23390. Dioctanoyl phosphatidylinositol 4,5-bisphosphate (dic8-PIP2) was purchased from Echelon Biosciences. Drugs were initially prepared in stock solution, aliquoted and stored at −20°C. For those chemicals requiring dimethyl sulfoxide (DMSO) as a solvent, the concentration of DMSO was less than 0.1%. This concentration of DMSO either in the recording pipettes or in the bath had no significant effects on neuronal activity.
Lei S., Hu B, & Rezagholizadeh N. (2021). Activation of V1a Vasopressin Receptors Excite Subicular Pyramidal Neurons by Activating TRPV1 and Depressing GIRK Channels. Neuropharmacology, 190, 108565.
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