PJ34 was purchased from Enzo Life Sciences (Farmingdale, NY, USA); ABT888 from APExBIO (Houston, TX, USA); XAV939 from Cayman chemical company (Ann Arbor, MI, USA); MG-132, ICG-001, and PNU-74654 from Selleckchem (Houston, TX, USA); nerve growth factor-7S (NGF) from Sigma-Aldrich (Burlington, MA, USA); rabbit polyclonal anti-TNKS1/2 antibody (H-350), mouse monoclonal anti-MAP2 antibody (AP20), mouse monoclonal anti-PAR antibody (10H), and ADP-HPD from Santa Cruz Biotechnology (Dallas, TX, USA); rabbit monoclonal anti-Axin1 antibody (C76H11), and rabbit monoclonal anti-unphosphorylated (Ser33/Thr41) β-catenin antibody (D13A1) from Cell Signaling Technology (Danvers, MA); DAPI, Alexa Fluor 488-conjugated goat anti-rabbit IgG, and Alexa Fluor 568-conjugated goat anti-mouse IgG from Thermo Fisher Scientific (Waltham, MA, USA)); and predesigned primers for real-time PCR from Takara Bio (Kusatsu, Japan).
Abt888
Manufactured by Apexbio
Sourced in United States
ABT888 is a lab equipment product manufactured by Apexbio. It is designed for use in research and scientific applications. The core function of ABT888 is to provide a reliable and efficient tool for conducting various laboratory experiments and analyses.
Automatically generated - may contain errors
Lab products found in correlation
4 6 diamidino 2 phenylindole (dapi), by Thermo Fisher Scientific (2 mentions)
Xav939, by Cayman Chemical (1 mentions)
Alexa fluor 568 conjugated goat anti mouse igg, by Thermo Fisher Scientific (1 mentions)
Pnu 74654, by Selleck Chemicals (1 mentions)
Nerve growth factor 7s ngf, by Merck Group (1 mentions)
Icg 001, by Selleck Chemicals (1 mentions)
Alexa fluor 488 conjugated goat anti rabbit igg, by Thermo Fisher Scientific (1 mentions)
Mg132, by Selleck Chemicals (1 mentions)
Cmc na, by Sangon (1 mentions)
Th588, by Merck Group (1 mentions)
5 and 6 chloromethyl 2 7 dichlorodihydrofluorescein diacetate acetyl ester cm h2dcfda, by Thermo Fisher Scientific (1 mentions)
Lipofectamine rnaimax reagent, by Thermo Fisher Scientific (1 mentions)
Vorinostat, by LC Laboratories (1 mentions)
3 protocols using abt888
1
Examining Wnt Signaling Pathway
2
Preparation of Cytotoxic Compounds for Cell and Animal Studies
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For cells, doxorubicin (DOX, purity 99.37%) was purchased from TargetMol (Target Molecule Corp., USA), and was dissolved in warm water to 10 mmol/L. Chrysophanol (CHR, purity 99.02%) was purchased from MCE (MedChemexpress, USA), and was diluted in warm DMSO to 20 mmol/L (Fig. 1 A). 3-Aminobenzamide (3AB, also called as INO-1001, purity 98.11%) was obtained from Selleck (Selleck Chemicals, USA), and was dissolved in DMSO to 10 mmol/L. ABT888 (veliparib, purity 99.51%) was from APExBIO (APExBIO Technology, Houston, USA), and was diluted in DMSO to 10 mmol/L. All the solutions are stored at –20 °C.
For animals, DOX (purity over 98%) was purchased from Sangon (Shanghai, China), and was dissolved in sterile normal saline (NS) to 2 mg/mL. CHR (purity over 98%) was purchased from Meilune (Dalian, China), and was dissolved in 0.1% sodium carboxymethylcellulose (CMC-Na, Sangon, Shanghai, China) to 20 mg/mL. 3AB (purity over 98%) was obtained from Meilune (Dalian, China), and was dissolved in sterile NS to 20 mg/mL.
For animals, DOX (purity over 98%) was purchased from Sangon (Shanghai, China), and was dissolved in sterile normal saline (NS) to 2 mg/mL. CHR (purity over 98%) was purchased from Meilune (Dalian, China), and was dissolved in 0.1% sodium carboxymethylcellulose (CMC-Na, Sangon, Shanghai, China) to 20 mg/mL. 3AB (purity over 98%) was obtained from Meilune (Dalian, China), and was dissolved in sterile NS to 20 mg/mL.
3
Evaluating Therapeutic Strategies for MTH1 Inhibition
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Vorinostat was obtained from LC laboratories (Boston, MA), and the ABT-888 was from APExBIO (Houston, TX). The MTH1 inhibitors TH588 and SCH51344 were obtained from Sigma (St. Louis Mo) and Tocris Bioscience (Bristol, UK), respectively. hOGG1 FLARETM assay kit was from Trevigen (Gaithersburg, MD), 5-(and-6)-chloromethyl-2′,7′-dichlorodihydrofluorescein diacetate, acetyl ester (CM-H2DCFDA) was obtained from ThermoFisher Scientific (Waltham, MA). SilencerR Select valudated siRNA and non-targeting (NT)-siRNA control were purchased from ambion (Carlsbad, CA) and Lipofectamine RNAiMAX reagent was from Invitrogen (Waltham, MA).
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