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Brl 37344

Manufactured by Bio-Techne
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BRL 37344 is a lab equipment product manufactured by Bio-Techne. It is a chemical compound used in research applications. The core function of BRL 37344 is to serve as a beta-3 adrenergic receptor agonist.

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Lab products found in correlation

Dorsomorphin, by Abcam (1 mentions) L748337, by Bio-Techne (1 mentions) Trans cinnamic acid, by Merck Group (1 mentions) Sr59230a, by Bio-Techne (1 mentions) Cyclodextran, by Merck Group (1 mentions) U46619, by Cayman Chemical (1 mentions) Cremophor el, by Merck Group (1 mentions) Nw nitro l arginine methylester hydrochloride l name, by Merck Group (1 mentions) Sr59230a, by Merck Group (1 mentions) N n dimethylformamide (dmf), by Merck Group (1 mentions)

4 protocols using brl 37344

1

Characterization of cinnamic acid

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Trans-cinnamic acid (99% purity, Figure 1A) was purchased from Sigma Chemical Co. (St. Louis, MO, USA). BRL 37344 and L-748.337 were purchased from Tocris Bioscience (Bristol, UK). AICAR was purchased from TCI (Chuo-ku, Tokyo, Japan). Dorsomorphin was purchased from Abcam (Cambridge, UK). All other chemicals used in this study were of analytical grade.
Kang N.H., Mukherjee S, & Yun J.W. (2019). Trans-Cinnamic Acid Stimulates White Fat Browning and Activates Brown Adipocytes. Nutrients, 11(3), 577.
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2

Transverse Aortic Constriction in Mice

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Transverse aortic constriction (TAC) was constructed as previously described. Briefly, mice were anesthetized with 2% isoflurane, endotracheally intubated with a 20G catheter, and ventilated. The transverse aortic arch was surgically accessed. Then, a 25G needle was placed on the transverse aorta, which was secured. Finally, the chest was closed after removing the needle, leaving a stenosis. Mice were administrated with BRL37344 (Tocris Bioscience, Ellisville, Missouri) or SR59230A, respectively, at 0.1 mg/kg/hour via osmotic minipumps.
Zhang M., Xu Y., Chen J., Qin C., Liu J., Guo D., Wang R., Hu J., Zou Q., Yang J., Wang Z, & Niu X. (2021). Beta3-Adrenergic Receptor Activation Alleviates Cardiac Dysfunction in Cardiac Hypertrophy by Regulating Oxidative Stress. Oxidative Medicine and Cellular Longevity, 2021, 3417242.
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3

BRL 37344 Activates β3AR-NO-cGMP Pathway

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Selective β3AR agonist BRL 37344 (BRL, 0.1 and 1.0 μmol/L, Tocris Bioscience) was used to assess β3AR induction of NO-sGC-cGMP signaling. cGMP levels were measured as above.
Trappanese D.M., Liu Y., McCormick R.C., Cannavo A., Nanayakkara G., Baskharoun M.M., Jarrett H., Woitek F.J., Tillson D.M., Dillon A.R., Recchia F.A., Balligand J.L., Houser S.R., Koch W.J., Dell’Italia L.J, & Tsai E.J. (2014). Chronic β1-adrenergic blockade enhances myocardial β3-adrenergic coupling with nitric oxide-cGMP signaling in a canine model of chronic volume overload: new insight into mechanisms of cardiac benefit with selective β1-blocker therapy. Basic research in cardiology, 110(1), 456.
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4

Pharmacological Agents for Hemodynamic Studies

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Nebivolol (Forest Research Institute, Jersey City, NJ) and BRL 37344 (Tocris Biosciences, Minneapolis, MN) were dissolved in a 15% cyclodextran (Sigma-Aldrich, St. Louis, MO) solution in 0.9% saline. Dobutamine hydrochloride (Cayman Chemical, Ann Arbor, MI), N-w-Nitro-L-Arginine Methyl Ester hydrochloride (L-NAME), and SR59230A (Sigma-Aldrich, St. Louis, MO) were dissolved in 0.9% NaCl.
Monocrotaline hydrochloride (Sigma Aldrich, St. Louis, MO) was dissolved in 1 N HCl, neutralized with 0.5N NaOH, and diluted with PBS. The filtered solution was then injected into the tail vein in a dose of 60 mg/kg. U46619 (Cayman Chemical, Ann Arbor, D r a f t 9 MI) was dissolved in 95% ethyl alcohol and diluted in 0.9% NaCl solution. Mirabegron (Astellas Pharm US, Northbrook, IL) was dissolved in 70% 0.9% NaCl, 15% Cremophor EL (Sigma Aldrich, St. Louis, MO), and 15% N,N-dimethylformamide (Sigma Aldrich, St.
Pankey E.A., Edward J.A., Swan K.W., Bourgeois C.R., Bartow M.J., Yoo D., Peak T.A., Song B.M., Chan R.A., Murthy S.N., Prieto M.C., Giles T.D, & Kadowitz P.J. (2016). Nebivolol has a beneficial effect in monocrotaline-induced pulmonary hypertension. Canadian journal of physiology and pharmacology, 94(7).
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