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112 protocols using spss software 23

1

Analyzing Immunotherapy Adverse Events

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Hazard ratios (HRs) and their 95% confidence intervals were estimated through the Cox regression proportional model; in the multivariate approach, a forward stepwise procedure was used, and the enter and remove limits were set to 0.05 and 0.10, respectively. The association of irAE frequency with biological parameters with clinical outcomes in the two patient cohorts was assessed by the chi-square test. Statistics were performed by the SPSS software 23.0 (International Business Machines Corp., New York, NY, USA) and R statistical software.
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2

Survival Analysis of Zoledronic Acid Impact

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Median follow-up was calculated by applying the reverse Kaplan–Meier methodology. Cox regression models were used to evaluate the effect of ZA and other risk factors on DFS and OS. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were estimated. Relevant risk factors described in the literature or found to have a P value of less than 0.1 in univariate analyses were incorporated in the multivariate model. All tests were two-tailed. P values of less than 0.05 were considered significant. All analyses were computed using SPSS software™ 23.0 (IBM Corp., Armonk, NY, USA).
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3

Pharmacokinetic Analysis of Dasatinib and Posaconazole

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The pharmacokinetic parameters were calculated using DAS software 3.0 (Bontz Inc., Beijing, China) with non-compartmental analysis. The mean concentration−time curves were constructed using GraphPad Prism 8.0 (GraphPad Software Inc., San Diego, USA). The nonparametric Mann–Whitney U-test was used to evaluate pharmacokinetics’ difference between dasatinib or posaconazole treatment alone group with two drugs combined treatment group by SPSS software 23.0 (IBM Corp., Chicago, USA). Pharmacokinetic profiles were expressed as mean±SD and pharmacokinetic parameters were presented as median (min-max). P < 0.05 represented statistical significance.
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4

Spatial Learning Assessment in Mice

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All statistical analyses were performed using the SPSS software 23.0 (IBM, Chicago, IL, USA). All data were presented as mean ± S.D (standard deviation). Comparison of multiple groups was performed by one-way analysis of variance (ANOVA), and intergroup comparison was conducted by the LSD test. The Escape latency in the Morris water maze test was analyzed using ANOVA. P < 0.05 was considered statistically significant.
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5

Comparative Sperm Morphology Analysis

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Statistical analysis was performed using SPSS software 23.0 (IBM Corp, New York, NY, USA). PSM analysis was conducted with SPSS software 23.0 and STATA software 15.0 (Stata Corp, College Station, TX, USA). Data were presented as the mean ± standard deviation (s.d.) and percentage. Difference between the teratozoospermia and normal sperm groups was determined by independent Student's t-test, Chi-square test, and Fisher's exact test. A two-sided P < 0.05 was considered statistically significant.
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6

Surgical Outcomes: A Statistical Analysis

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Continuous data are reported as median ± interquartile range (IQR) or mean ± standard deviation (SD). Patients served as their own control, and pre- and postoperative data were compared using the two-tailed, paired Student’s t test. Categorical demographic and baseline variables are reported as proportions or frequencies, and compared using Wilcoxon test for continuous outcomes and McNemar’s test for paired samples. A p value < 0.05 was considered statistically significant. Parameters of the univariate analysis with p < 0.05 were included in a multivariate logistic regression test to determine what independent variables might predict the clinical success of the surgical procedure. A p value < 0.05 was considered statistically significant. Statistical analyses were performed using SPSS software 23.0 (IBM, Armonk, New York, U.S.).
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7

Weight Loss Surgery Outcomes Analysis

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We expressed continuous variables as mean and measures of dispersion (standard deviation; SD). We reported categorical variables as a percentage. For analysis, we categorized the variables based on (a) gender (male/female), (b) age (≤43 or >43 years), (c) initial BMI (<40 or ≥40 kg/m2), (d) procedure type (restrictive or malabsorptive techniques), (e) PA status (inactive or minimally active/active), (f) MedDiet adherence level (low adherence ≤ 6 and medium–high adherence > 6 points), (g) depression status (none or minimal and mild–severe), and (h) %TBWL (≤25% vs. 25.1–39.9% vs. ≥40%). Bivariate analyses of proportionality of distribution of categorical variables Chi-square test (χ2). For continuous variables, we used the Kolmogorov–Smirnov test to check that the variables were normally distributed. For comparisons of normally distributed variables, we used the T-Student test or ANOVA. For comparisons of non-normally distributed variables, we used the Mann–Whitney or Kruskal–Wallis tests.
We performed multivariable regression analysis to study the relationship between changes in PSC and MSC scores as dependent variables and age, gender, %TBWL, changes in PA, depression status, and initial summary component values as independent variables.
We performed statistical analysis using IBM SPSS Software 23.0. p < 0.05 was considered significant.
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8

Statistical Analysis of Experimental Data

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Statistical analyses were performed using SPSS Software (23.0) (IBM, New York, USA). The level of significance was calculated by means of the chi-square-test (Χ² test). The level of significance was set at α = 0.05.
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9

Comparative Analysis of PBT and DBT

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Comparative statistical analyses between the PBT group and DBT group were performed in SPSS software 23.0 (IBM Company, Chicago, United States). Measurement data were expressed as mean ± standard deviation. Unpaired t test was used for comparisons between the two groups. Count data were analyzed using χ2 test. Statistical significance was set at p < 0.05.
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10

Multivariate Statistical Analysis of Data

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Data were analyzed using IBM SPSS software 23.0(IBM Corp., Armonk, NY, USA). The mean, standard deviation, skewness, kurtosis, and reliability (Cronbach’s alpha) of each item were computed using SPSS 23.0. Normality of the data was tested with skewness and kurtosis, and the reliability of the items was determined by Cronbach’s alpha. Additionally, correlation analysis (Pearson’s correlation coefficient), model fit (comparative fit index (CFI), root mean square error of approximation (RMSEA), standardized root mean square residual (SRMR)), and path analyses among the variables were conducted using AMOS 23.0 (Build 1607, IBM Corp., Armonk, NY, USA).
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