Ici 118 511

Manufactured by Bio-Techne

ICI‐118,511 is a selective beta-2 adrenergic receptor antagonist. It functions by binding to and blocking the activity of the beta-2 adrenergic receptor. The product is intended for research use only and its precise applications should be determined by the user.

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Lab products found in correlation

A922500, by Cayman Chemical (1 mentions) Atglistatin sml1075, by Merck Group (1 mentions) Bafilomycin a1 b1793, by Merck Group (1 mentions) Propranolol hydrochloride, by Bio-Techne (1 mentions) Or486, by Bio-Techne (1 mentions) Sr59230a, by Bio-Techne (1 mentions)

2 protocols using ici 118 511

Inflammatory Response Modulation Assay

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All fatty acids and A922500 (10012708) were from Cayman. E coli LPS (L4391), (±)‐Norepinephrine (+)‐ bitartrate salt (A0937), fenoterol hydrobromide (F1016), bafilomycin A1 (B1793), and atglistatin (SML1075) were from Sigma. Interleukin‐4 (214‐14) was from Peprotech. ICI‐118,511 (0821) was from Tocris.

Petkevicius K., Bidault G., Virtue S., Jenkins B., van Dierendonck X.A., Dugourd A., Saez‐Rodriguez J., Stienstra R., Koulman A, & Vidal‐Puig A. (2021). Norepinephrine promotes triglyceride storage in macrophages via beta2‐adrenergic receptor activation. The FASEB Journal, 35(2), e21266.

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Delivery of Beta-Adrenergic Antagonists for Experimental Studies

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OR486 (Tocris, Ellisville, MO) was dissolved in a 5:3:2 ratio of dimethylsulfoxide (DMSO), 0.9% saline and ethanol.^{30 (link)} For peripheral experiments βAR antagonists propranolol hydrochloride (Tocris, Ellisville, MO), ICI-118,511 (Tocris, Ellisville, MO) and SR59230A (Tocris, Ellisville, MO) were each dissolved in 5:3:2 ratios of DMSO, 0.9% saline and ethanol. For i.t. and i.c.v. experiments, βAR antagonists were dissolved in 0.9% saline. Drug solutions were injected into pumps, which were placed in 15mL conical tubes containing sterile 0.9% saline and primed overnight in a dry heat bath (Lab Armor, Cornelius, OR) at 37°C. All pumps (other than those for i.t. delivery) were attached to corresponding catheters prior to priming. Subcutaneous delivery of OR486 was at a constant rate of 15mg/kg/day for a 2-week period. Peripheral delivery of propranolol hydrochloride was at 9mg/kg/day, ICI-118,511 was at 1.5mg/kg/day and SR59230A was at 1.67mg/kg/day. I.t. delivery of propranolol hydrochloride was at 50ug/day for the low dose experiments and 100ug/day for the high dose experiments; ICI-118,511 was at 30ug/day; and SR59230A was at 20ug/day. I.c.v. delivery of propranolol hydrochloride was at 50ug/day for the low dose experiments and 100ug/day for the high dose experiments; ICI-118,511 was at 30ug/day; and SR59230A was at 20ug/day.

Ciszek B.P., O'Buckley S.C, & Nackley. A.G. (2016). Persistent COMT-dependent pain is initiated by peripheral, but not spinal or central, β2- and β3- adrenergic receptors. Anesthesiology, 124(5), 1122-1135.

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