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Stable isotopically labeled compounds

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Stable isotopically labeled compounds are chemically modified versions of molecules that contain one or more atoms replaced with their stable isotopic counterparts. These compounds are used as analytical and research tools in various scientific disciplines.

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Lab products found in correlation

G2si q tof system, by Waters Corporation (2 mentions) Cary 300 spectrophotometer, by Agilent Technologies (2 mentions) 5 mm tci cryoprobe, by Bruker (2 mentions) Avance 3 600 mhz spectrometer, by Bruker (2 mentions)

2 protocols using stable isotopically labeled compounds

1

Analytical Characterization of Compounds

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Stable isotopically labeled compounds were purchased from Cambridge Isotope Laboratories, Inc. The corresponding unlabeled compounds were purchased from ThermoFisher Scientific. All solvents used for UPLC and HPLC were Optima grade, and water used for chromatography was purified by a Milli-Q water purification system. High resolution MS for pure compounds and metabolomics experiments were performed on a Water Synapt G2Si q-TOF system. NMR spectra were acquired on a Bruker AVANCE III 600 MHz spectrometer, with a 5 mm TCI cryoprobe, and referenced to residual solvent proton and carbon signals. UV spectra were obtained on an Agilent Cary 300 spectrophotometer. Optical rotations were measured on a Perkin Elmer 341 polarimeter.
McCaughey C.S., van Santen J.A., van der Hooft J.J., Medema M.H, & Linington R.G. (2021). An Isotopic Labeling Approach Linking Natural Products with Biosynthetic Gene Clusters. Nature chemical biology, 18(3), 295-304.
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2

Analytical Characterization of Compounds

Check if the same lab product or an alternative is used in the 5 most similar protocols
Stable isotopically labeled compounds were purchased from Cambridge Isotope Laboratories, Inc. The corresponding unlabeled compounds were purchased from ThermoFisher Scientific. All solvents used for UPLC and HPLC were Optima grade, and water used for chromatography was purified by a Milli-Q water purification system. High resolution MS for pure compounds and metabolomics experiments were performed on a Water Synapt G2Si q-TOF system. NMR spectra were acquired on a Bruker AVANCE III 600 MHz spectrometer, with a 5 mm TCI cryoprobe, and referenced to residual solvent proton and carbon signals. UV spectra were obtained on an Agilent Cary 300 spectrophotometer. Optical rotations were measured on a Perkin Elmer 341 polarimeter.
McCaughey C.S., van Santen J.A., van der Hooft J.J., Medema M.H, & Linington R.G. (2021). An Isotopic Labeling Approach Linking Natural Products with Biosynthetic Gene Clusters. Nature chemical biology, 18(3), 295-304.
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