Amitriptyline hydrochloride

Manufactured by Bio-Techne

Amitriptyline hydrochloride is a white, crystalline powder that is soluble in water, alcohol, and chloroform. It is a tricyclic antidepressant medication commonly used in the treatment of depression, neuropathic pain, and other conditions.

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Lab products found in correlation

Fluoxetine hydrochloride, by Bio-Techne (1 mentions) Anti tuj1, by BioLegend (1 mentions) Anti cdk5, by Santa Cruz Biotechnology (1 mentions) Sb206553, by Merck Group (1 mentions) Roscovitine, by Selleck Chemicals (1 mentions) Trimipramine maleate, by Merck Group (1 mentions) Sc 17320, by Santa Cruz Biotechnology (1 mentions) Anti actin, by Merck Group (1 mentions) Anti app ctf, by Merck Group (1 mentions) Sb271046, by Selleck Chemicals (1 mentions) Sb742457, by Selleck Chemicals (1 mentions) Sb215505, by Merck Group (1 mentions) Sertraline hydrochloride, by Pfizer (1 mentions) Sc 6170, by Santa Cruz Biotechnology (1 mentions) Sb258585, by Bio-Techne (1 mentions) Recombinant human bdnf, by Thermo Fisher Scientific (1 mentions) L 685 458, by Selleck Chemicals (1 mentions) Anti adam10 ab1997, by Abcam (1 mentions) Fluoxetine, by Selleck Chemicals (1 mentions) Igf 1, by Thermo Fisher Scientific (1 mentions)

2 protocols using amitriptyline hydrochloride

Pharmacological Characterization of Fluoxetine and Amitriptyline

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Fluoxetine hydrochloride (# 0927) and Amitriptyline hydrochloride (# 4456/50) were purchased from Tocris, VU0134992 (VU992) was synthesized at Vanderbilt University Medical Center as recently reported (Kharade et al., 2018 (link)). All other drugs were purchased from Sigma. All drugs were dissolved in PSS, except VU992, which was initially dissolved in DMSO and then added to aqueous solutions. PSS or DMSO (for VU992) were used as vehicle controls, correspondingly.

Isaeva E., Bohovyk R., Fedoriuk M., Shalygin A., Klemens C.A., Zietara A., Levchenko V., Denton J.S., Staruschenko A, & Palygin O. (2022). Crosstalk between ENaC and basolateral Kir4.1/Kir5.1 channels in the cortical collecting duct. British journal of pharmacology, 179(12), 2953-2968.

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Pharmacological Modulation of BACE1 and APP Processing

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Fluoxetine, TAPI-1, SB271046, SB742457, L-685,458 and roscovitine were purchased from Selleck Chemicals. Amitriptyline hydrochloride, ST1936 and SB258585 were from Tocris Bioscience. Protriptyline hydrochloride, amoxapine, trimipramine maleate, SB215505, SB206553, cAMP, L-ascorbic acid and DAPI were purchased from Sigma. Escitalopram oxalate was purchased from Lundbeck. Sertraline hydrochloride was from Pfizer. BACE inhibitor IV (BSI IV) was from Calbiochem. Recombinant human BDNF, GNDF, and IGF-I were from Peprotech. CellTiter-Glo was from Promega. Immunoblotting was performed with the following antibodies: anti-ADAM10 (Ab1997, Abcam), anti-BACE1 N-termimus (AP7774b, Abgent), anti-APP-CTF (A8717, Sigma), anti-actin (A2066, Sigma), anti-CDK5 (sc-173, Santa Cruz), and Rabbit anti-β-arrestin-1/2 (A1CT) antibody was a kind gift from Dr. Robert J. Lefkowitz. Immunofluorescence staining was performed with the following primary antibodies: anti-Tuj1 (801201, BioLegend), anti-Sox2 (sc-17320, Santa Cruz), anti-Map2 (Ab5622, Millipore), and anti-GFAP (sc-6170, Santa Cruz).

Li X., Wang Q., Hu T., Wang Y., Zhao J., Lu J, & Pei G. (2017). A tricyclic antidepressant, amoxapine, reduces amyloid-β generation through multiple serotonin receptor 6-mediated targets. Scientific Reports, 7, 4983.

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