Fenbendazole

Manufactured by MedChemExpress

Sourced in United States

Fenbendazole is a benzimidazole compound that acts as an anthelmintic agent. It is commonly used in veterinary medicine to treat parasitic infections in animals. The core function of fenbendazole is to disrupt the microtubule structure of parasitic worms, leading to their death or expulsion from the host.

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Lab products found in correlation

Plcγ1, by Cell Signaling Technology (1 mentions) Goat anti rabbit igg hrp, by Cell Signaling Technology (1 mentions) Horseradish peroxidase hrp conjugated goat anti mouse igg, by Cell Signaling Technology (1 mentions) Phospho akt p akts473, by Cell Signaling Technology (1 mentions) Gapdh, by Cell Signaling Technology (1 mentions) β actin, by Cell Signaling Technology (1 mentions)

2 protocols using fenbendazole

Antibody Characterization in BoHV-1 Research

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In this study, the following antibodies and chemicals were used, including fenbendazole (MedChemExpress, cat# HY-B0413). The antibodies against phospho-Akt(p-Akt) (S473) (Cell Signaling Technology; cat# 9271), Akt (Cell Signaling Technology; cat # 9272), PLC-γ1(Cell Signaling Technology, cat# 2822S), p-PLC-γ1(Ser1248) (Cell Signaling Technology, cat# 8713), GAPDH (Cell Signaling Technology, cat# 2118), and β-Actin (Cell Signaling Technology; cat# 4970) were used. Goat anti-BoHV-1 serum was purchased from VMDR Inc, Gandhinagar, India [20PAB-IBR]. HRP-(horseradish peroxidase-) conjugated goat anti-mouse IgG (Cell Signaling Technology, cat# 7076), HRP-goat anti-rabbit IgG (Cell Signaling Technology, cat# 7074), and HRP-donkey anti-goat IgG H&L (Abcam, ca# ab97110).
BoHV-1 VP16 antibody (1:2,000) was kindly provided by Prof. Vikram Misra at the University of Saskatchewan [20 (link)].

Chang L, & Zhu L. (2020). Dewormer drug fenbendazole has antiviral effects on BoHV-1 productive infection in cell cultures. Journal of Veterinary Science, 21(5), e72.

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Benzimidazole Anthelmintic Compound Screening

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SIMCOMP^{24 (link)}, a similar compound search tool, was used to identify 20 drugs with structures similar to that of ABZ. Of these, seven benzimidazole anthelmintics including ABZ were selected for examination. ABZ, oxibendazole, PBZ, fenbendazole, oxfendazole, mebendazole, and flubendazole were purchased from MedChemExpress, USA. Scaffold compounds (benzimidazole and carbendazim) were used as control. Benzimidazole was purchased from Tokyo Chemical Industry Co., Ltd. Carbendazim was synthesized from Mcule, USA.

Matsuo H., Inagami A., Ito Y., Ito N., Iyoda S., Harata Y., Higashitani M., Shoji K., Tanaka M., Noura M., Mikami T., Kato I., Takita J., Nakahata T, & Adachi S. (2024). Parbendazole as a promising drug for inducing differentiation of acute myeloid leukemia cells with various subtypes. Communications Biology, 7, 123.

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