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Slfn5 targeting rna oligonucleotides

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SLFN5 targeting RNA oligonucleotides are synthetic, single-stranded RNA molecules designed to specifically target and bind to the SLFN5 gene transcript. The primary function of these oligonucleotides is to modulate the expression of the SLFN5 gene, which is involved in various cellular processes. These products are intended for research use only and do not have any implied or suggested therapeutic applications.

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Lab products found in correlation

Gapdh antibody, by Merck Group (2 mentions) Amaxa nucleofector kit, by Lonza (2 mentions) Recombinant human ifnα, by Roche (2 mentions) Adult human normal brain lysate ab30078, by Abcam (2 mentions) Myc tag, by Cell Signaling Technology (2 mentions)

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RNA oligonucleotides (5 citations) Oligonucleotides (2 citations)

2 protocols using slfn5 targeting rna oligonucleotides

1

Interferon Signaling Pathway Regulation

Check if the same lab product or an alternative is used in the 5 most similar protocols
Recombinant human IFNα was obtained from Hoffmann-La Roche (USA). Recombinant human IFNβ was obtained from Biogen Idec (USA). Adult human normal brain lysate (ab30078) was obtained from Abcam (USA). The antibodies against STAT1, STAT3, STAT5 and Myc-Tag, were obtained from Cell Signaling Technology (USA). SLFN5, SLFN11 and SLFN12L antibodies were obtained from Sigma Aldrich (USA). GAPDH antibody was obtained from Millipore (USA). For RNAi mediated gene silencing, cells were transfected with double stranded control non-targeting or SLFN5 targeting RNA oligonucleotides (Santa Cruz Biotechnology, Santa Cruz, CA.). For transfection, Amaxa™ nucleofector kits from Lonza were used according to the manufacturer's instructions.
Arslan A.D., Sassano A., Saleiro D., Lisowski P., Kosciuczuk E.M., Fischietti M., Eckerdt F., Fish E.N, & Platanias L.C. (2017). Human SLFN5 is a Transcriptional Co-repressor of STAT1-Mediated Interferon Responses and Promotes the Malignant Phenotype in Glioblastoma. Oncogene, 36(43), 6006-6019.
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2

Interferon Signaling Pathway Regulation

Check if the same lab product or an alternative is used in the 5 most similar protocols
Recombinant human IFNα was obtained from Hoffmann-La Roche (USA). Recombinant human IFNβ was obtained from Biogen Idec (USA). Adult human normal brain lysate (ab30078) was obtained from Abcam (USA). The antibodies against STAT1, STAT3, STAT5 and Myc-Tag, were obtained from Cell Signaling Technology (USA). SLFN5, SLFN11 and SLFN12L antibodies were obtained from Sigma Aldrich (USA). GAPDH antibody was obtained from Millipore (USA). For RNAi mediated gene silencing, cells were transfected with double stranded control non-targeting or SLFN5 targeting RNA oligonucleotides (Santa Cruz Biotechnology, Santa Cruz, CA.). For transfection, Amaxa™ nucleofector kits from Lonza were used according to the manufacturer's instructions.
Arslan A.D., Sassano A., Saleiro D., Lisowski P., Kosciuczuk E.M., Fischietti M., Eckerdt F., Fish E.N, & Platanias L.C. (2017). Human SLFN5 is a Transcriptional Co-repressor of STAT1-Mediated Interferon Responses and Promotes the Malignant Phenotype in Glioblastoma. Oncogene, 36(43), 6006-6019.
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