Nicolet avatar 330

Fourier transform infrared spectroscopy (FTIR; Thermo Nicolet AVATAR 330, Madison, WI, USA) was performed after discs of a KBr and nanofibers had been made. The samples were ground with 150 mg dry KBr in a mortar and pestle, then compressed into a disc with 10 t pressure. The discs were scanned 128 times over the range of 4000–400 cm⁻¹ and with a resolution of 4 cm⁻¹.

CIP, physical mixture, and CIP-loaded nanofibers were characterized by X-ray powder diffraction (XRPD; D8 Advance, Bruker AXS GmbH, Karlsruhe, Germany). The samples were measured with Cu K λ_I radiation (40kV/40mA, λ = 1.5406 Å) in between diffraction angle 3–40° for their structural properties.
Differential scanning calorimeter (DSC; Mettler Toledo DSC821e; Mettler Inc., Schwerzenbach, Switzerland) was applied to evaluate the thermal behavior of the samples using 25–300 °C temperature range at a heating rate of 5 °C min⁻¹.
Fourier transform infrared spectroscopy (FTIR; Thermo Nicolet AVATAR 330, Madison, WI, USA) was performed after discs of a KBr and nanofibers had been made by a compression molding technique. The discs were scanned 128 times over the range 4000–400 cm⁻¹ and with a resolution of 4 cm⁻¹.

The pure drug, IR cores, and ER coated pellet formulations were subjected to IR spectroscopy using Fourier Transform Infrared (FTIR) spectrophotometer (Thermo Nicolet Avatar, 330) to determine the interaction between active drug and excipients. Spectra were scanned from 4,000 to 500 cm⁻¹ wavenumber using OMNIC Spectra Software.