Doxycycline hyclate

Manufactured by Ssniff

Sourced in Germany

Doxycycline hyclate is a chemical compound used as a laboratory reagent. It is a tetracycline-class antibiotic, commonly utilized in scientific research and analysis.

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Lab products found in correlation

Microtainer sst, by BD (1 mentions) K2e tubes, by BD (1 mentions)

2 protocols using doxycycline hyclate

In Vivo MR Silencing via Doxycycline

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To achieve MR silencing in vivo, doxycycline (Dox) was administered by offering food pellets containing 735 mg/kg doxycycline hyclate (Ssniff Spezialdiäten, Soest, Germany; effective concentration: 625 mg/kg Dox) ad libitum to the mice for at least 14 days. Control animals received a standard diet from the same supplier. Blood was collected by heart puncture after having sacrificed the mice, and serum and plasma were separated using Microtainer SST or K2E tubes, respectively (BD Biosciences, Heidelberg, Germany). In order to perform gene expression and histological analyses, individual organs were dissected and either snap-frozen in liquid nitrogen or fixed in formaldehyde solution.

Montes-Cobos E., Li X., Fischer H.J., Sasse A., Kügler S., Didié M., Toischer K., Fassnacht M., Dressel R, & Reichardt H.M. (2015). Inducible Knock-Down of the Mineralocorticoid Receptor in Mice Disturbs Regulation of the Renin-Angiotensin-Aldosterone System and Attenuates Heart Failure Induced by Pressure Overload. PLoS ONE, 10(11), e0143954.

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Doxycycline Inhibits Matrix Metalloproteases

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Inhibition of matrix metalloproteases was achieved by feeding mice a diet containing doxycycline. Doxycycline intake was about 5 mg/day per mouse (doxycycline hyclate, Ssniff, Germany).

Coutens B., Lejards C., Bouisset G., Verret L., Rampon C, & Guiard B.P. (2023). Enriched environmental exposure reduces the onset of action of the serotonin norepinephrin reuptake inhibitor venlafaxine through its effect on parvalbumin interneurons plasticity in mice. Translational Psychiatry, 13, 227.

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