A patient cohort comprised of 498 patients from the TCGA Research Network. Two Illumina Infinium HumanMethylation450 BeadChip beads (cg12324970 and cg23095743) were used to calculate relative methylation levels of PITX3 by the formula 100 %*bead_M/(bead_M + bead_U). The average value of the ratios of the beads cg12324970 and cg23095743 was calculated. BCR-free survival was considered as the primary endpoint of the study. For PITX2, three Illumina Infinium HumanMethylation450 BeadChip beads (cg10391633, cg01616926, and cg19134945) were analyzed, accordingly.
Infinium humanmethylation450 beadchip beads
Manufactured by Illumina
The Infinium HumanMethylation450 BeadChip is a microarray-based technology designed to analyze DNA methylation patterns. It targets over 480,000 CpG sites across the human genome, providing comprehensive coverage of gene regions as well as CpG islands. The BeadChip is a tool for researchers to study the epigenetic landscape of their samples.
Automatically generated - may contain errors
Lab products found in correlation
1 protocol using infinium humanmethylation450 beadchip beads
1
PITX3 and PITX2 Methylation Profiling
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