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Standard protected amino acids

Manufactured by Bachem
Sourced in United States

Standard protected amino acids are essential building blocks used in the synthesis of peptides and proteins. They provide a stable and controlled environment for the construction of complex molecular structures. These amino acids are routinely employed in various analytical and laboratory applications that require precise chemical modifications and controlled reactions.

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2 protocols using standard protected amino acids

1

Solid-Phase Peptide Synthesis Reagents

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The Rink amide ChemMatrix resin was purchased from Biotage (Charlotte, NC), Fmoc-protected PAL-PEG-PS was purchased from APPTec LLC (Louisville, KY), and the 2-chlorotrityl chloride resin was purchased from Chem-Impex International (Wood Dale, IL). All standard protected amino acids were purchased from Bachem (King of Prussia, PA), EMD Millipore Chemicals (San Diego, CA), Peptides International (Louisville, KY), or Chem-Impex International, Fmoc-L-Tyr(All)-OH and Fmoc-L-Tyr-OH were obtained from Chem-Impex International. The coupling agent benzotriazol-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate (PyBOP) and 1-hydroxybenzotriazole hydrate (HOBt) were obtained from Peptides International. Second-generation Grubbs’ catalyst (G II) and second-generation Hoveyda Grubbs’ catalyst (HG II) were purchased from Aldrich Chemical Co. (Milwaukee, WI). 4-Methylpiperidine was purchased from Acros Organics (Morris, NJ). NMP, DCM, N,N-diisopropylethylamine (DIEA), DMF, diethyl ether, acetonitrile, methanol, and TFA were purchased from Fisher Scientific (Hampton, NH). All other chemicals were purchased from Aldrich Chemical Co.
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2

Peptide Synthesis on Rink Amide Resin

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Rink amide ChemMatrix resin was purchased from Biotage (Charlotte, NC, USA). All standard protected amino acids were purchased from Bachem (King of Prussia, PA, USA), EMD Millipore Chemicals (San Diego, CA, USA), Peptides International (Louisville, KY, USA), or Chem-Impex International. All chiral amino acids are of the L-isomer unless otherwise indicated, and abbreviations are used according to the IUPAC-IUB Joint 704 Commission of Biochemical Nomenclature [41] (link). Fmoc-Tyr(All)-OH and Fmoc-AllGly-OH were purchased from Chem-Impex International (Wood Dale, IL, USA). The coupling agent benzotriazol-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate (Py-BOP) was obtained from P3 BioSystems (Louisville, KY, USA), and the coupling additive 1-hydroxybenzotriazole hydrate (HOBt) was obtained from Chem-Impex International. Solvents, N,N-diisopropylethylamine (DIEA), and trifluoroacetic acid (TFA) were purchased from Fisher Scientific (Hampton, NH, USA). All other chemicals were purchased from Aldrich Chemical Co. (Milwaukee, WI, USA).
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