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273 protocols using spss 25.0 for windows

1

Comparative Analysis of Clinical Outcomes

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Continuous variables are here presented as median and range. These variables were compared using the Mann–Whitney U test. Categorical variables are presented as numbers. The chi-squared test or Fisher’s exact test were used to analyze categorical variables. Statistical significance was set at p < 0.05. All statistical analyses were performed using SPSS 25.0 for Windows (IBM, Armonk, NY, USA).
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2

Survival Analysis of Biomarkers in Cancer

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Data of qPCR and IHC analyses were statistically analyzed under REMARK criteria (17 (link)) with SPSS 25.0 for Windows (IBM Corp.). The endpoint of the study was overall survival. Overall survival time was calculated from the date of diagnosis until the last date of contact or death. The cut-offs used for survival analyses were selected using the software tool 'Cutoff-Finder' (http://molpath.charite.de/cutoff/index.jsp). Multivariate survival analyses were performed using the Cox proportional hazards model (Table III). Univariate analysis of survival data was performed according to Kaplan and Meier (Figs. 1C-F, 2 and 4). The log-rank test was used to test the significance between the groups. The non-parametric, Wilcoxon matched-pairs signed rank test and the Mann-Whitney test were used to investigate significant differences between the patient groups (Figs. 1A, 4D and S1). The Bonferroni's correction for multiple testing was considered for Fig. 1A. Correlation analyses were performed using the nonparametric Spearman's rank correlation analysis (Figs. 3, 4B, 5C and D and S2). A P-value <0.05 was considered significant. Data were visualized with GraphPad Prism 9 (GraphPad Software, Inc.) and SPSS 25.0 (IBM Corp.).
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3

Statistical Analysis of Research Data

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Data were analyzed using SPSS 25.0 for Windows (IBM Corp. Released 2017, IBM SPSS Statistics for Windows, Version 25.0, IBM Corp). Data are presented as mean ± s.d. for quantitative variables and as number (percentage) for qualitative ones. Variables were tested for normality with the Kolmogorov–Smirnov test. Comparisons between subgroups were performed using the independent samples t-test (normally distributed data) and the Mann–Whitney U test (non-normally distributed data). Frequencies were compared with the chi-squared test. Correlations were estimated by Pearson’s or Spearman’s correlation tests, as appropriate. All tests were two-tailed, and a P value of less than 0.05 was considered significant.
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4

BCAA Intake and Childhood Obesity

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The general characteristics (continuous and categorical variables) of both mothers and children according to quartiles of children’s daily BCAA intake levels were performed using the chi-square test or general linear model. Logistic regression models were used to estimate odds ratios of childhood overweight and insulin resistance according to children’s daily different BCAA intake levels. BCAAs were evaluated in the following two ways: (1) as quartiles; and (2) as a continuous variable. All analyses were adjusted for maternal age, gestational age, education and smoking status, pre-pregnancy BMI and gestational weight gain, and children’s sex, age, birth weight, and feeding status (categorical variables) (Model 1), and then children’s lifestyles including outdoor physical activity time (continuous variables), screen watching time (continuous variables), and sleep time (categorical variables) (Model 2), as well as children’s daily total energy intake (Model 3). All the statistical analyses were performed with the SPSS 25.0 for windows software package (IBM SPSS statistics 25). Two-sided P <0.05 was considered statistically significant.
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5

Propensity-score-matched Analysis of T1N0M0 SRCC

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The clinicopathological characteristics of the two propensity-score-matched groups of T1N0M0 SRCC patients treated by PN or RN were compared. The values of unordered categorical variables were compared by chi-square tests. Normality of the quantitative variables was conducted by Kolmogorov-Smirnov and Shapiro-Wilk normality tests. The values of unordered categorical variables were compared by chi-square tests. The unpaired Student’s t-test was employed to compare the means of two continuous variables with a normal distribution. The Mann-Whitney U test was used to compare continuous variables that did not have a normal distribution. The Kaplan-Meier estimator was utilized to estimate the cumulative survival, and the log-rank test was used to draw comparisons. The statistical analysis was performed with SPSS 25.0 for Windows (IBM Corp., Armonk, NY, USA). All tests were two-tailed, and significance was indicated when P<0.05.
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6

Factors Influencing Need for Ophthalmologist Referral

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Statistical analyses were performed using IBM SPSS® 25.0 for Windows (IBM, Armonk, New York, USA). Continuous variables were tested for normality using the Shapiro–Wilk test. Continuous variables are presented as the median, minimum, and maximum because they were not normally distributed (P < 0.05). Binary variables are presented as numbers and percentages. Nominal variables are presented as numbers with percentages per category. To statistically compare variables between groups, the Mann–Whitney U test was used for continuous variables and the chi-square test was used for dichotomous and nominal variables. Pairwise correlation was additionally assessed using Spearman's rank correlation coefficients. The influence of age, gender, education, smoking status, diabetes, arterial hypertension, neurological pathology, autoimmune pathology, intraocular lens status, familial history of glaucoma, familial history of AMD, intake of vitamin preparations for the prevention of AMD, the presence of a corrected refractive error, and previous ophthalmologist visits on the need for referral to an ophthalmologist was studied. Statistical significance was accepted based on two-sided P values of <0.05.
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7

Maternal GDM and HDP Impact on Child Obesity

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Differences in the general characteristics (continuous and categorical variables) of both mothers and children according to maternal different status of GDM and HDP were tested using the univariate analysis of variance or chi-square test. We used the general linear models.
to compare children's Z scores for BMI and used logistic regression models to estimate odds ratios of childhood overweight according to maternal different status of GDM and HDP. All analyses were adjusted for maternal age, gestational age, education, smoking status, history of treatment of GDM, and HDP, children's sex, age, birth weight, and feeding status (Model 1), and then children's lifestyles including outdoor physical activity time, screen watching time, sleep time, daily energy intake, energy from fat and dietary fiber intake (Model 2), and further for maternal pre-pregnancy BMI and gestational weight gain (Model 3). All the statistical analyses were performed with SPSS 25.0 for windows software package (IBM SPSS statistics 25) and SAS Proprietary Software 9.4 (SAS Institute Inc., Cary, NC, USA). Two-sided P < 0.05 was considered statistically significant.
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8

Statistical Analysis of Experimental Findings

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All values were expressed as mean ± standard deviation or median, and the Mann–Whitney U test was used for intergroup comparison. SPSS® 25.0 for Windows (IBM, Chicago, U.S.A.) was used for statistical analysis, and p < 0.05 was defined as significantly different for all values.
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9

Structural Equation Modeling in Wearable Device Research

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Structural equations among latent constructs were examined to test the conceptual structural equation model (SEM). The SEM was used to analyze causal models and simultaneously estimate a series of interrelated dependence relationships. Thus, data analysis was carried out using structural estimation modeling. Before this study tested the research model, SPSS 25.0 for Windows (IBM Corp) was used to show the important descriptive information on demographic variables, including participant characteristics such as gender, age, and educational background. This information also included behaviors related to the use of wearable medical devices, such as the time spent on the internet, the preferred online medical platform provider, and the frequency of using wearable medical devices. Model evaluation involved a two-step analysis [22 (link)] using the software IBM Amos 21.0. For this purpose, the author first built a measurement model using confirmatory factor analysis for the model to check its fit and then built the SEM and examined the hypothesized causal paths among the constructs by performing a simultaneous test. This helped to observe whether the conceptual framework had provided an acceptable fit to the empirical data.
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10

Breastfeeding Duration and Child Development

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Although the criterion for breastfeeding duration to group participants vary widely in previous studies, many studies included “never,” “1 month,” “3 months,” “6 months,” and “12 months” as the duration criteria [6 (link)]. In our study, participants were grouped by the following breastfeeding durations according to previous studies [9 (link), 18 (link)]: “never,” “up to 1 month,” “1–3 months,” “3–6 months,” “6–12 months,” “12–18 months” and “over 18 months.” We used logistic regression to investigate the odds ratio for delayed development of the early period (T1, 5.5 months to T3, 26.2 months) assessed by Denver II and K-ASQ. To compare the outcomes of K-ASQ as continuous variables, language ability at T4 (38.7 months), and intelligence and academic function at T9 (99.2 months) among the groups of breastfeeding duration, analysis of variance (ANOVA) and analysis of covariance (ANCOVA) were utilized. In all analyses, the adjusted model included the children’s sex, age, gestational age, birth weight, parents’ education level, and household income as covariates. To adjust for multiple comparisons included in our analysis, we performed the Benjamini–Hochberg test with a false discovery rate threshold of 0.05 for the crude and adjusted models, respectively [19 (link)]. Statistical analyses were conducted using the software package SPSS 25.0 for Windows (IBM Co., Armonk, NY, USA).
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