20 channel array head coil

Anatomical T1-weighted MRI was acquired using a 3T scanner (PRISMA, Siemens AG Erlangen, Germany) with a 20-channel array head coil. In order to obtain a highresolution anatomical image of each participant's brain, an anatomical T1-weighted 2D magnetization-prepared rapid gradient echo sequence was used (repetition time/inversion time/echo time 2,300/900/4.18 ms, flip angle 9°, field of view 256 × 256 mm 2 , matrix 256 × 256, 176 slices, voxel size 1 × 1 × 1 mm 3 ). We used the CAT 12 toolbox (Computational Anatomy Toolbox 12) of the structural brain mapping group (Jena University Hospital, Germany), which is implemented in Statistical Parametric Mapping 12 (Institute of Neurology, London, UK) for voxel-based morphometry (VBM) analysis. 24 For white matter hyperintensities, a global burden was calculated using Fazekas scale for periventricular and deep white matter lesions. 25 An optimized method of VBM segmentation was applied using customized templates and prior probability maps with diffeomorphic anatomical registration exponentiated lie algebra (Dartel). 25 Images were smoothed with an 8-mm full-width at halfmaximum smoothing kernel.