Symbia

All DPD scans were performed by using either a hybrid SPECT/CT gamma camera (BrightView, Philips Healthcare, Amsterdam, the Netherlands) or a SPECT gamma camera (Symbia, Siemens Healthineers, Erlangen, Germany) following the injection of ∼700 MBq DPD.
The imaging protocol involved an early (5 min) and late (3 h) planar whole-body image, with a SPECT/CT or SPECT only scan of the chest at 3 h. If a CT scan was not performed in the same sitting, then a contemporary CT scan of the chest was used for attenuation correction and SUV analysis (n = 9 patients). DPD scans were reported by 2 experienced clinicians using the Perugini grading system (6 (link)), with grade 0 being negative and grades 1 to 3 increasingly positive.
Planar whole-body scans were performed at a scan speed of 20 cm/min; the matrix size was 256 × 1,024 on the Siemens Symbia and 512 × 1,024 on the Philips BrightView. SPECT acquisitions used a contoured orbit with 120 views in a 360° orbit, with 20 s per view and a matrix size of 128 × 128. CT acquisitions of the chest (performed as part of the SPECT/CT imaging) were low dose, ungated, free-breathing, and noncontrast.

The sentinel node detection was carried out using a 2-day protocol, which involves the injection performed on the afternoon of the day before the surgery and the scintigraphy performed 1 h after the injection. Each patient received 55.5 MBq in 1 ml of Tc-99m phytate delivered peritumorally in each breast. The injection in each breast was given at four sites: two superficial and two deep injections [17 (link)]. One hour after the injection, planar images in 3 directions (anterior, 30° oblique, and 60° oblique views) were taken, and each scan time was 2 min with 512 × 512 matrices [13 (link)]. An additional lateral view was taken when no image was obtained on three views. The SPECT/CT study then followed, with 10 s’ data collection for each step, with 45 steps for 180 degrees of collection (dual cameras) with 128 × 128 matrices, and then, CT was performed to produce axial and coronal fusion images. Both planar imaging and SPECT/CT were performed using a Siemens Symbia Intevo16 (Siemens Healthcare) equipped with a low-energy high-resolution (LEHR) collimator.

¹²³I-MIBG myocardial scintigraphy was performed as follows. 111 MBq of ¹²³I-MIBG was injected intravenously. Myocardial images were acquired using a standard-field gamma camera (Symbia, SIEMENS Healthcare; Tokyo, Japan) equipped with a medial energy collimator. A 15% window centered at 159 KeV was used. Anterior view planar imaging of the chest was performed for 240 s. Identical acquisitions were obtained at 15 min after tracer injection (early images) and at 3 h after tracer injection (delayed images). Images were acquired using 512 × 512 matrices and a 1.0 zoom ratio. To evaluate the myocardial accumulation of ¹²³I-MIBG, the H/M ratio was calculated from both the early and delayed images.

In this study 74, MBq/kg of radiopharmaceutical was injected intravenously through amarginal ear vein. A total of 296 MBq^99mTc-MIBI and ^99mTc-liposomal agents diluted in 5 mL saline was administered. Images were acquired with a double-headed gamma camera (Symbia, Siemens health care, IL, USA) and a low-energy, high-resolution parallel whole collimator in whole-body (WB) scanning mode with a 128 × 128 matrix at a zoom factor of 1.45 and 300 s per WB image after 5 min, 1 h, and 24 h. The energy windows were set to 140 keV ± 20%, and the images were obtained immediately and 1 h and 24 h after tracer injection. The region of interest (ROI) was manually drawn on WB images in all the acquisitions to determine the organ activity at each time point.