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Symbia

Manufactured by Siemens
Sourced in Germany, United States

The Symbia is a compact and versatile gamma camera system designed for high-performance single-photon emission computed tomography (SPECT) imaging. It offers a range of field-of-view and detector configurations to meet the needs of various clinical applications. The Symbia's core function is to acquire and reconstruct SPECT images, providing physicians with detailed information about the body's physiological processes and anatomical structures.

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25 protocols using symbia

1

Cardiac [123I]mIBG Imaging Protocol

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All individuals were administered 111 MBq (±10%) [123I]mIBG via slow intravenous injection. Potassium iodate tablets (170 mg) were given before and after injection to minimise uptake of free iodine by the thyroid. Ten-minute anterior planar images were acquired at 20 min (early) and at 4 h (± 30 min) after injection (delayed). All images were acquired on a dual-headed Siemens Symbia Intevo or Siemens Symbia gamma camera (Siemens Healthcare, Munich, Germany) with medium energy low penetration (MELP) collimators with an energy window of 159 keV ± 10%, matrix size 128 × 128 and no zoom applied [3 (link),13 (link)].
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2

Multimodal Imaging of Parathyroid Adenomas

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Patients received 20 MBq of 123I intravenously. Two hours later, 750 MBq of 99mTc-sestamibi was injected. SPECT/CT acquisition was started 10 minutes after the 99mTc-sestamibi administration. All SPECT/CT acquisitions were performed with Siemens Symbia T or Siemens Intevo T2 imaging systems (Siemens, Erlangen, Germany). Immediately after the SPECT/CT acquisition, a static pinhole image of the neck was acquired with a SKYLight gamma camera (Philips Healthcare, USA) or with Siemens Symbia or Intevo T2 systems (Siemens, Erlangen, Germany) beginning in 2015. All acquisition parameters are shown in Table 1.
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3

Dual-Head SPECT Perfusion Lung Imaging

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All patients were examined in the supine position with a dual-head gamma-camera system (Symbia; Siemens Healthineers, Forchheim, Germany). Perfusion lung SPECT acquisition was started after a slow intravenous injection of 185-MBq Tc-labeled macroaggregated albumin (MAA) over two to three breathing cycles using the following parameters: energy window, 140.5 keV ± 15%; number of projections (per detector), 30; projection speed, 20 s per projection; detector configuration, 360 degrees; matrix size, 128 × 128; pixel size, 2.7 × 2.7 mm2; and slice thickness, 2.7 mm.
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4

Imaging Striatal Dopamine Transporter

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Four hours after injection of 5.6 (0.3) mCi, Mean (SD), of 123I-ioflupane (DaTscan), SPECT images of the head were acquired using a gamma camera (Symbia, Siemens, USA).
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5

Cardiac Radionuclide Imaging for ATTR-CM

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All DPD scans were performed by using either a hybrid SPECT/CT gamma camera (BrightView, Philips Healthcare, Amsterdam, the Netherlands) or a SPECT gamma camera (Symbia, Siemens Healthineers, Erlangen, Germany) following the injection of ∼700 MBq DPD.
The imaging protocol involved an early (5 min) and late (3 h) planar whole-body image, with a SPECT/CT or SPECT only scan of the chest at 3 h. If a CT scan was not performed in the same sitting, then a contemporary CT scan of the chest was used for attenuation correction and SUV analysis (n = 9 patients). DPD scans were reported by 2 experienced clinicians using the Perugini grading system (6 (link)), with grade 0 being negative and grades 1 to 3 increasingly positive.
Planar whole-body scans were performed at a scan speed of 20 cm/min; the matrix size was 256 × 1,024 on the Siemens Symbia and 512 × 1,024 on the Philips BrightView. SPECT acquisitions used a contoured orbit with 120 views in a 360° orbit, with 20 s per view and a matrix size of 128 × 128. CT acquisitions of the chest (performed as part of the SPECT/CT imaging) were low dose, ungated, free-breathing, and noncontrast.
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6

Cardiac [123I]MIBG Scintigraphy Protocol

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At baseline, all subjects underwent cardiac [123I]MIBG scintigraphy (performed according to the standard operating procedures of the Department of Nuclear Medicine, UMR, Germany): After blocking of the gastric and thyroid sodium iodide symporters, images were acquired 4 h after injection of 185 MBq (±10%) [123I]MIBG (AdreView Iobenguane, GE Healthcare, Braunschweig, Germany) using a dual-head gamma camera with a low energy high resolution collimator (Siemens, Symbia, Erlangen, Germany) at a window setting of 159 keV (±10%). Regions of interest (ROI) were manually placed on planar anterior images. A rectangular ROI was used for the mediastinum and a circular one for the left ventricle of the heart. According to the in-house code, the heart-to-mediastinum ratio of [123I]MIBG-binding of < 1.5 was considered to be pathological.
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7

Sentinel Node Mapping via Peritumoral Tc-99m Phytate

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The sentinel node detection was carried out using a 2-day protocol, which involves the injection performed on the afternoon of the day before the surgery and the scintigraphy performed 1 h after the injection. Each patient received 55.5 MBq in 1 ml of Tc-99m phytate delivered peritumorally in each breast. The injection in each breast was given at four sites: two superficial and two deep injections [17 (link)]. One hour after the injection, planar images in 3 directions (anterior, 30° oblique, and 60° oblique views) were taken, and each scan time was 2 min with 512 × 512 matrices [13 (link)]. An additional lateral view was taken when no image was obtained on three views. The SPECT/CT study then followed, with 10 s’ data collection for each step, with 45 steps for 180 degrees of collection (dual cameras) with 128 × 128 matrices, and then, CT was performed to produce axial and coronal fusion images. Both planar imaging and SPECT/CT were performed using a Siemens Symbia Intevo16 (Siemens Healthcare) equipped with a low-energy high-resolution (LEHR) collimator.
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8

Planar Scintigraphy and SPECT/CT Imaging

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Directly after the RSV, each patient underwent a post-therapeutic planar scintigraphy with a single-head gamma camera (Nucline TH, Mediso) using 186Re gamma emission (137 keV photopeak, 10% energy window). Two patients also aunderwent a single photon emission computed tomography/computed tomography (SPECT/CT) with a hybrid gamma camera (Symbia, Siemens) (Figs. 2 and 3).
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9

Quantifying Myocardial 123I-MIBG Uptake

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123I-MIBG myocardial scintigraphy was performed as follows. 111 MBq of 123I-MIBG was injected intravenously. Myocardial images were acquired using a standard-field gamma camera (Symbia, SIEMENS Healthcare; Tokyo, Japan) equipped with a medial energy collimator. A 15% window centered at 159 KeV was used. Anterior view planar imaging of the chest was performed for 240 s. Identical acquisitions were obtained at 15 min after tracer injection (early images) and at 3 h after tracer injection (delayed images). Images were acquired using 512 × 512 matrices and a 1.0 zoom ratio. To evaluate the myocardial accumulation of 123I-MIBG, the H/M ratio was calculated from both the early and delayed images.
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10

Biodistribution of 99mTc-MIBI and 99mTc-Liposomal Agents

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In this study 74, MBq/kg of radiopharmaceutical was injected intravenously through amarginal ear vein. A total of 296 MBq99mTc-MIBI and 99mTc-liposomal agents diluted in 5 mL saline was administered. Images were acquired with a double-headed gamma camera (Symbia, Siemens health care, IL, USA) and a low-energy, high-resolution parallel whole collimator in whole-body (WB) scanning mode with a 128 × 128 matrix at a zoom factor of 1.45 and 300 s per WB image after 5 min, 1 h, and 24 h. The energy windows were set to 140 keV ± 20%, and the images were obtained immediately and 1 h and 24 h after tracer injection. The region of interest (ROI) was manually drawn on WB images in all the acquisitions to determine the organ activity at each time point.
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