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Monoclonal anti il 22 clone 8e11 blocking antibody

Manufactured by Genentech
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Sourced in United States

Monoclonal anti-IL-22 (Clone 8E11) blocking antibody is a laboratory research reagent that recognizes and binds to the interleukin-22 (IL-22) protein. It is designed to inhibit the activity of IL-22 in experimental settings.

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Lab products found in correlation

Recombinant il 22, by Thermo Fisher Scientific (2 mentions)

2 protocols using monoclonal anti il 22 clone 8e11 blocking antibody

1

Blocking IL-22 Mitigates DNA Damage

Check if the same lab product or an alternative is used in the 5 most similar protocols
Monoclonal anti-IL-22 (Clone 8E11) blocking antibody was kindly provided by Genentech (South San Francisco, USA). Anti-IL-22 (150μg/mouse) or control IgG were injected 36h, 12h before and 12h after inducing DNA damage. For reconstitution, mice were injected with recombinant IL-22 (400ng/mouse, Peprotech) i.p. every 8h for three days prior to the damage induction and at 8h and 16h afterwards. Epithelial cells were isolated 24h after damage. For the stimulation of ATM expression, mice were injected with recombinant IL-22 (500 ng/mouse, Peprotech) i.p. 12h and 2h prior to epithelial isolation.
Gronke K., Hernández P.P., Zimmermann J., Klose C.S., Kofoed-Branzk M., Guendel F., Witkowski M., Tizian C., Amann L., Schumacher F., Glatt H., Triantafyllopoulou A, & Diefenbach A. (2019). Interleukin-22 protects intestinal stem cells against genotoxic stress. Nature, 566(7743), 249-253.
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2

Blocking IL-22 Mitigates DNA Damage

Check if the same lab product or an alternative is used in the 5 most similar protocols
Monoclonal anti-IL-22 (Clone 8E11) blocking antibody was kindly provided by Genentech (South San Francisco, USA). Anti-IL-22 (150μg/mouse) or control IgG were injected 36h, 12h before and 12h after inducing DNA damage. For reconstitution, mice were injected with recombinant IL-22 (400ng/mouse, Peprotech) i.p. every 8h for three days prior to the damage induction and at 8h and 16h afterwards. Epithelial cells were isolated 24h after damage. For the stimulation of ATM expression, mice were injected with recombinant IL-22 (500 ng/mouse, Peprotech) i.p. 12h and 2h prior to epithelial isolation.
Gronke K., Hernández P.P., Zimmermann J., Klose C.S., Kofoed-Branzk M., Guendel F., Witkowski M., Tizian C., Amann L., Schumacher F., Glatt H., Triantafyllopoulou A, & Diefenbach A. (2019). Interleukin-22 protects intestinal stem cells against genotoxic stress. Nature, 566(7743), 249-253.
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