76 toddlers (38 ASD and 38 TD) recruited in our previous study 14 (link) were used as a replication sample. Toddlers were recruited through clinical referral or advertisements and were diagnosed by the same licensed psychologist with the above-mentioned criteria. sMRI scans were collected at the same site with a 1.5T Siemens Symphony system during toddler’s natural sleep at night. A total of 170 sMRI scans were collected at intake and follow-up visits. All replication sMRI scans were preprocessed with FreeSurfer 5.3 using the same pipeline and same Linux platform as used for main samples. Similarly, sMRI scans with excessive motion or bad segmentation quality were excluded, yielding 167 scans from 75 unique toddlers (38 ASD, 37 TD; 55 male, 20 female) for testing the replicabilities of ASD vs. TD differences identified from main sample. The detailed participant recruitment, diagnosis evaluation, and scan collection information can be found in 14 (link).
Symphony system
Manufactured by Siemens
Sourced in Germany
The Symphony system is a high-performance laboratory instrument designed for analytical applications. It features advanced data processing capabilities and is capable of performing a wide range of analytical techniques. The Symphony system is engineered to deliver reliable and accurate results, supporting researchers and scientists in their work.
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Lab products found in correlation
2 protocols using symphony system
1
Replication of ASD-TD Differences in Toddlers
2
Cardiac MRI Delayed Enhancement Protocol
Check if the same lab product or an alternative is used in the 5 most similar protocols
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The cardiac MRI protocol was performed on a 1.5T Siemens Symphony system (Erlangen, Germany). Approximately 8 to 9 minutes after administration of 0.015 to 0.02 mmol/kg of gadobutrol (Gadovist, Bayer Hellas AG), a multiphase inversion-recovery steady-state free precession scan ("TI-scout") was acquired in the mid short-axis plane to determine the optimal inversion time (TI) to null normal myocardium for delayed enhancement imaging. The time that corresponded to the image with sufficiently nulled myocardium was input as the TI into the subsequent inversion recovery segmented turbo flash sequence used for delayed enhancement imaging. Typically, the TI spanned 230 to 330 ms over the course of the study. Other imaging parameters were: repetition time/echo time/flip = 700 ms/4.18 ms/25 deg, 8 mm thickness, field of view = 255×340 mm, 192×256, and 25 segments. Acquisition was performed in the short axis, covering the left ventricle from base to apex. In addition, single slices were acquired in the long axis, 4-chamber and 3-chamber views. The TI was increased as needed as time passed (10-20 minutes after gadobutrol administration). To quantify the myocardial scar, short-axis delayed enhancement images were analyzed by using the freely available for research purposes software Segment, version 1.9 R2354 (http://segment.heiberg.se; Figure 2).
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