Vx 10 fundus camera

We used Cirrus HD OCT 5000 with optic disc cube 200 × 200 protocol and macular cube 512 × 128 protocol. RNFL thickness measurement was done by a certified optician. Participants were scanned in pupillary dilation which was obtained with tropicamide 1%. The fundus photograph was taken for each eye using the Kowa VX-10 fundus camera. The resulting images were masked and reviewed by 2 experts based on the agreed operational definition. If any discrepancy happened between the 2 reviewers, a third person would make the decision.

Comprehensive ocular examinations that included log MAR best-corrected visual acuity (BCVA) testing, intraocular pressure (IOP), refractive error, slit-lamp examination, color fundus photography, SD-OCT (3D OCT-2000, Topcon, Tokyo Japan), and fluorescein angiography was performed for baseline measurement prior to injection. These procedures, with the exception of fluorescein angiography, were also conducted after 1, 2, and 3 months of injections. SD-OCT was performed using a macular cube scan (512 × 128). The standardized macular cube protocol consists of 128 horizontal B-scan lines each composed of 512 A-scans with an acquisition time of 2.4 s over a 6-mm square that was centered on the fovea. The central macular thickness (CMT), defined as the average retinal thickness in the central subfield of a standard ETDRS grid, was automatically calculated using built-in software.
Using color fundus photographs (VX-10 fundus camera, Kowa), the HEs in all patients were measured quantitatively on semi-automated imaging software using the protocol developed by Sasaki [18 (link)] described below.