UDCA raw material was purchased from Parafarm (Buenos Aires, Argentina); Polyethylene glycol 400 (PEG 400) was provided from Sigma-Aldrich (St. Louis, MO, USA) and Hydroxypropylmethylcellulose E-15 (HPMC) was obtained from Parafarm (Buenos Aires, Argentina); acetone was provided by Sintorgan (Buenos Aires, Argentina); Poloxamine 1107 (Tetronic 1107, T1107, MW 15 kDa) was procured by BASF Corporation (Florham Park, NJ, USA); D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) was obtained from Eastman Chemical Company (Kingsport, TN, USA); maltose was provided by Boehringer Ingelheim (Ingelheim am Rhein, Germany) and mannitol was obtained from J. T. Baker (Philipsburg, NJ, USA).
Polyethylene glycol 400 peg 400
Manufactured by Merck Group
Sourced in United States, Germany, India, United Kingdom
Polyethylene glycol 400 (PEG 400) is a colorless, viscous liquid with a molecular weight of approximately 400 g/mol. It is a widely used laboratory reagent and industrial chemical. PEG 400 serves as a solvent, plasticizer, and humectant in various applications.
Automatically generated - may contain errors
Lab products found in correlation
Tween 80, by Merck Group (6 mentions)
Tween 20, by Merck Group (6 mentions)
Propylene glycol, by Merck Group (6 mentions)
Formic acid, by Merck Group (5 mentions)
Dimethyl sulfoxide (dmso), by Merck Group (4 mentions)
Acetonitrile, by Thermo Fisher Scientific (4 mentions)
Isopropyl myristate, by Merck Group (4 mentions)
Triply deionized water, by Merck Group (4 mentions)
Ethanol, by Merck Group (4 mentions)
Triethanolamine, by Merck Group (4 mentions)
Heparin sodium, by Merck Group (3 mentions)
Methanol, by Merck Group (3 mentions)
Glycerol, by Merck Group (3 mentions)
Ketoconazole, by Tokyo Chemical Industry (2 mentions)
Hplc grade water, by Thermo Fisher Scientific (2 mentions)
Limonene, by Merck Group (2 mentions)
Labrafac cc, by Gattefosse (2 mentions)
Rpmi 1640 medium, by Thermo Fisher Scientific (2 mentions)
Streptomycin, by Thermo Fisher Scientific (2 mentions)
Penicillin, by Thermo Fisher Scientific (2 mentions)
58 protocols using polyethylene glycol 400 peg 400
1
Formulation and Characterization of UDCA Solid Dispersions
2
Synthesis and Characterization of CCG-211790
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The synthesis of CCG-211790 has been described previously [9 (link)]. Tween® 80 (polyoxyethylene-20-sorbitan monooleate), polyethylene glycol 400 (PEG 400) and dimethyl sulfoxide (DMSO) were purchased from Sigma-Aldrich (Saint Louis, MO, USA). Propylene glycol was purchased from MP Biomedicals LLC (Irvine, CA, USA). Acetonitrile and sodium dodecyl sulfate (SDS) were purchased from Fisher Scientific (Pittsburgh, PA, USA). Fractionated coconut oil was purchased from Piping Rock Health Products, LLC (Ronkonkoma, NY, USA). Ethanol was purchased from Decon Laboratories Inc. (Detroit, MI, USA). Liquid coconut oil was purchased from Piping Rock Health Products, LLC (Ronkonkoma, NY, USA) and used as received. Deionized water was supplied from a Culligan reverse osmosis filtration system (Rosemont, IL, USA). All chemicals except coconut oil were of analytical or high-performance liquid chromatography (HPLC) grade.
3
Quantification of RPG and QCT in Plasma
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RPG (purity > 98%), QCT (purity ≥ 95%), and ketoconazole (used as an internal standard; purity ≥ 98%) were purchased from Tokyo Chemical Industry Co. (Tokyo, Japan) Ethanol, dimethyl sulfoxide, polyethylene glycol 400 (PEG 400), carboxymethyl cellulose (CMC), potassium phosphate monobasic/dibasic, β-Nicotinamide adenine dinucleotide phosphate (NADPH), and phosphate-buffered saline (PBS) were purchased from Sigma-Aldrich (St. Louis, MO, USA). Pooled male Sprague-Dawley rat plasma and pooled male human plasma were purchased from Innovative Research, Inc. (Novi, MI, USA) Pooled HLM and RLM were purchased from BD-Genetech (Woburn, MA, USA).
4
Efinaconazole Topical Formulation Development
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Efinaconazole was received as a gratis sample kindly donated by Lupin, Pune, India. Butylated hydroxytoluene (BHT), disodium ethylenediaminetetraacetic acid (EDTA), isopropyl myristate, isopropyl palmitate, Labrafil®, Labrasol®, N-Methyl-2-pyrrolidone, polyethylene glycol 400 (PEG 400), polyvinylpyrrolidone K30 (PVP K30), propylene glycol, Transcutol® P, and Tween 80, were obtained commercially (Sigma Aldrich, St. Louis, MO, USA). Ethyl alcohol, isopropyl alcohol, acetonitrile, and potassium dihydrogen phosphate were obtained from Qualikems, New Delhi, India.
5
Nanoscale Drug Delivery System Formulation
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Span 80 (Mw = 428.60 g/mol; HLB = 4.3), Tween 80 (Mw = 1310 g/mol; HLB = 15), cholesterol powder (Mw = 386.6 g/mol, purity > 99%), polyethylene glycol 400 (PEG400), and vancomycin (Mw = 1449.3 g/mol) were purchased from Sigma Aldrich (Milan, Italy). Ethanol (anhydrous, ≥99.9%) was purchased from Carlo Erba Reagents (Cornaredo (MI), Italy). Distilled water was produced in situ using a lab-scale distiller. Carbon dioxide (CO2, >99.4%) was purchased from Morlando Group Srl (Naples, Italy).
6
Alectinib Treatment in Eml4-Alk Mice
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Eml4-Alk mice were randomized to receive either control vehicle or alectinib (MedChemExpress), at 20 mg/kg prepared directly in drug vehicle, daily by oral gavage for 14 consecutive days. Drug vehicle consisted of: 10% (v/v) dimethylsulfoxide (DMSO; Sigma Aldrich), 10% (v/v) Cremophor EL (Sigma Aldrich), 15% (v/v) poly(ethylene glycol)-400 (PEG400; Sigma Aldrich), 15% (w/v) (2-Hydroxypropyl)-β-cyclodextrin (Sigma Aldrich). Mice were monitored daily for weight loss and clinical signs. Investigators were not blind with respect to treatment.
7
Lysophospholipid Signaling Pathway Protocol
8
Extraction and Analysis of S. chinensis
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Polyethylene glycol 400 (PEG 400) and heparin sodium were purchased from Sigma-Aldrich (St. Louis, MO, USA). Pentobarbital sodium was obtained from SCI Phar-matech (Toayuan, Taiwan). S. chinensis was purchased from Kaiser Pharmaceutical Co., Ltd. (Tainan, Taiwan). Methanol, ethyl acetate and formic acid were obtained from E. Merck (Darmstadt, Germany). Triply deionized water (Millipore, Bedford, MA, USA) was used for all preparations.
9
Protopanaxadiol Formulation Development
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20(S)-Protopanaxadiol (PPD) (purity>98.0%) was obtained from Xian Plant Bio-Engineering Co., Ltd. (Shaan Xi, China). PEG-8 Caprylic/Capric Glycerides (LAS), Labrafac CC and Lauoroglycol CC were obtained from Gattefosse Co. (Saint Priest, Cedex, France). Capmul MCM EP was obtained from ARITEC Co. (Columbus, OH, USA). Miglyol 812 N and Poloxamer 188 were gifts from OLEO Chemicals (Witten, Germany) and BASF Co. (Ludwigshafen, Germany), respectively. Limonene, Tween 20, Tween 80, polyethylene glycol 400 (PEG400) and isopropyl myristate were obtained from Sigma-Aldrich Co. (St. Louis, MO, USA). Cetyl palmitate was obtained from TCI (Tokyo Kasei, Japan). Strat-M™ was purchased from Merck Millipore (Billerica, MA, U.S.A.). HPLC-grade water, acetonitrile, and methanol were obtained from Thermo Fisher Scientific Co. (Pittsburgh, PA, USA).
10
Neuroprotective Agent Evaluation Protocol
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Sodium pentobarbital, STZ, Nω-nitro-l- arginine methyl ester (l- NAME), thiobutabarbital sodium salt hydrate (Inactin® salt hydrate), methylene blue, 2,3,5-triphenyltetrazolium chloride (TTC), and poly-ethylene glycol 400 (PEG400) were purchased from Sigma-Aldrich, MO, USA. The chemicals for the physiological buffer were purchased from J.T. Baker, Capital Scientific Inc. and Wako Pure Chemical Industries. CAPA and 3,4-dimethoxyl caffeic acid phenethyl amide (dmCAPA, Figure 1 ) were synthesized and obtained from Institute of Chemistry, National Taiwan University [31 (link)]. CAPA was dissolved in PEG400 30% for intraperitoneal injection or suspended in distilled water for oral administration.
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