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Harmonic ace

Manufactured by Johnson & Johnson
Sourced in United States, Japan

The Harmonic Ace is a surgical instrument designed for precise tissue dissection and coagulation. It utilizes high-frequency mechanical vibrations to effectively cut and seal tissue, minimizing bleeding during surgical procedures.

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9 protocols using harmonic ace

1

Laparoscopic Cholecystectomy Technique

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Infraumbilical incision was placed and deepened. A 10-mm camera port was inserted by open technique and pneumoperitoneum was established. Subsequent ports were placed under vision for a standard 'four-port' LC. It included a 10-mm epigastric port, and additional two 5-mm ports were placed in the right midclavicular line and the right anterior axillary line. Adhesiolysis was performed [Figure 1a] when required. Energy devices were used liberally. Calot's triangle was carefully dissected to avoid bleeding [Figure 1b]. This was aided by ultrasonic shears (Harmonic Ace™, Ethicon Endo-Surgery, USA), sealer/divider (LigaSure™, Medtronic, Dublin, Ireland) and a 5-mm bipolar diathermy.
Dominant collateral veins were preferentially divided between two clips or Hem-o-lok (Hem-o-lok clip, Weck Closure Systems, Research Triangle Park, NC) [Figure 1c]. The cystic artery was divided between 5 mm Hem-o-lok clips [Figure 1d]. The cystic duct along with the collaterals was divided between two 5/10 mm Hem-o-lok clips [Figure 1e]. Endostapler was used for wide cystic ducts. The GB is gently retracted to avoid bleeding from the collateral veins in the GB fossa [Figure 1f]. Dominant veins were again clipped and divided while dissecting the GB of the liver bed. GB was retrieved through the umbilical port. Haemostasis was achieved and an abdominal drain was placed if needed.
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2

Laparoscopic Right Hemicolectomy Technique

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Laparoscopic surgery of all the patients was operated by the same surgeon. First, assess the mass for its resectability. Then lift up transverse colon and identify C of duodenum. Just on the inferior side of duodenum make the incision over peritoneum with Harmonic Ace (Ethicon Endosurgery, Cincinnati). Pass a gauze piece, and CO2 itself insufflates in to dissect duodenum and kept away from operative injury. We adopt the medial-to-lateral approach, so the vessels are taken very near to the origin of the superior mesenteric artery with a clearance of lymph nodes. Ileocolic and right branch of middle colic vessels are clipped proximally and on specimen side. True right colic vessels are present only in about 10%–15% of patients.[2 (link)] Along the white line of Toldt, mobilise entire right colon with up to mid transverse level. This step is done with care to prevent injury to the right ureter and gonadal vessels. Now, the resection and anastomoses can be done extracorporeally by delivering colon through 5 cm sized incision in the right iliac fossa. The resectional margin of colon should be at least of 5 cm. For specimen removal, we use glove bag so as to prevent contamination of the wound by tumour cells.
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3

Liver Resection Techniques and Safety Measures

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Operative technique followed common clinical standards [4 ]. Intraoperative ultrasonography confirmed preoperative imaging findings and excluded new manifestations. In open surgery, the Cavitron Ultrasonic Surgical Aspirator (CUSA®, Integra LifeSciences, Plainsboro NJ, USA) was used for parenchymal transection, with clipping or ligation of vascular and biliary structures. In laparoscopic cases, either the THUNDERBEAT (Olympus K.K., Tokyo, Japan), HARMONIC ACE® (Ethicon Inc. Somerville, NJ, USA) or laparoscopic CUSA® (Integra LifeSciences, Plainsboro NJ, USA) devices were employed, combined with ECHELON™ vascular staplers (Ethicon, Somerville, New Jersey, USA) or Weck® Hem-o-lok® polymer clips (Teleflex Inc., Pennsylvania, USA). Pringle maneuvers were applied as needed. Anatomical or parenchyma-sparing resections were chosen according to general patient condition, preoperative liver function tests, and limiting factors, such as macrovascular invasion. Resection margins were controlled intraoperatively with frozen section examination.
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4

Standardized Liver Resection Technique

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Operative technique adhered to common clinical standards for liver resection9 (link). Intraoperative sonography confirmed preoperative imaging findings and ruled out new or undetected lesions. The Cavitron Ultrasonic Surgical Aspirator (CUSA®, Integra LifeSciences, Plainsboro NJ, USA) was used for parenchymal transection in open surgery, with clipping or ligation of vascular and biliary structures. In laparoscopic cases, either the THUNDERBEAT (Olympus K.K., Tokyo, Japan), HARMONIC ACE® (Ethicon Inc. Somerville, NJ, USA) or laparoscopic CUSA® (Integra LifeSciences, Plainsboro NJ, USA) devices were combined with ECHELON™ vascular staplers (Ethicon, Somerville, New Jersey, USA) or Weck® Hem-o-lok® polymer clips (Teleflex Inc., Pennsylvania, USA). Intermittent Pringle maneuvers were carried out as needed. Anatomical or parenchyma-sparing resections were carried out according to general patient condition, preoperative liver function tests, and limiting factors, such as macrovascular invasion. Radicality of tumor resection was controlled through frozen section. Anesthesiologic management aimed for a low central venous pressure (CVP) during the resection phase.
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5

Laparoscopic Splenectomy Procedure

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The patient is placed in lateral decubitus, to enter the abdomen using a
trans-umbilical open technique and a 12 mm trocar is placed. Through it a 10 mm
30o scope is inserted. A subcostal 5 mm trocar is placed under direct
vision at the level of the anterior axillary line and another 5 mm port is inserted
at the midepigastric region. Using a 5 mm harmonic scalpel (Harmonic Ace, Ethicon)
and 5 mm instruments, access is gained to the lesser sac by dividing the
gastrosplenic ligament and short vessels until the upper pole of the spleen. The
splenic flexure of the colon is mobilized to get the lower pole of the spleen freed.
The posterior splenorenal ligament is then freed.
Once the spleen is completely dissected free from all of its hilum attachments,
splenic artery and vein are clipped with hemolocks and divided with scissors. It is
suggested clipping the artery first and then the vein, this can reduce the size of
the spleen in an important percentage. This is specially useful when dealing with
great size spleen. Then an endobag is used to retrieve the spleen after being
morcellated through the umbilical incision. A drain, exteriorized through the lateral
5 mm trocar is used routinely.
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6

Standardized Thyroid Total Thyroidectomy

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Every TT was performed by experienced endocrine surgeons and with standardized surgical technique. In some cases, an ultrasound scalpel (Harmonic Ace; Ethicon Endosurgery, Blue Ash, Cincinnati, OH) was used and hemostasis was completed with the use of Floseal Hemostatic Matrix (Baxter, Zurich, Switzerland). Recurrent laryngeal nerve was routinely bilaterally identified until its insertion into the larynx. In case of removal or injury of the parathyroid glands, the auto-implantation was carried out at the level of the stern-mastoid muscle. The central neck compartment lymph node dissection included prelaryngeal, pretracheal and paratracheal lymph nodes basin on the ipsilateral and contralateral side to the tumor. Drainage was used selectively in group B and it was not used in group A. Serum calcium level was evaluated in the first two postoperative days and after one week from surgery.
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7

Bipolar Surgical Sealing Devices Comparison

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We used seven bipolar SSDs—ENSEAL TRIO®, ENSEAL Round®, ENSEAL Articulating® (Ethicon Endosurgery, Cincinnati, Ohio, USA), LigaSure V®, LigaSure Blunt®, LigaSure Maryland® (Medtronic PLC, Dublin, Ireland), and BiClamp® (Erbe, Tübingen, Germany)—and two UCSs—HARMONIC ACE®+ (Ethicon Endosurgery) and THUNDERBEAT® (Olympus, Tokyo, Japan)—in this study (Table 1).
The side opposite to the part responsible for heat generation was defined as the back of the AB in the tip of the SSD (Figure 1A). ABs were inside, and the backs of ABs were covered by a seal plate to protect organs from heat injury for the bipolar SSDs. One of the blades was a double-edged AB, and the outside of the other, a movable blade, was defined as the back of the AB for the UCSs (Figure 1A).
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8

Surgical Techniques for Laparoscopic Resection

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Surgical techniques of LR in our institution were described previously [17 (link)18 (link)19 (link)]. The choice between LLR or open LR (OLR) depended on the preferences of individual patients and their surgeons. The selection criteria for choosing the laparoscopic approach were surgeon-dependent and are described in a previous study [10 ]. The indication of OLR included tumor size of greater than 10 cm, except when the tumor was of the pedunculated type; reconstruction of vascular or biliary conduit; proximity to an important vital structure that is deemed difficult to dissect laparoscopically; and invasion to adjacent organs necessitating concomitant resection and reconstruction. A flexible laparoscopic camera was used while maintaining the intraperitoneal pressure of 11 to 12 mmHg during LLR. A Cavitron ultrasonic surgical aspirator (Excel; Valleylab, Boulder, CO, USA) was used in OLR and different energy devices (Sonicison or Ligasure from Medtronic, Minneapolis, MN, USA; Harmonic Ace from Ethicon, Somerville, NJ, USA) were applied in LLR in accordance with the surgeon’s decision [20 (link)].
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9

Laparoscopic Hepatic Metastasectomy Technique

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A standardized approach was used. Patients were placed in a supine position with legs apart and if required on a beanbag. After placement of 3-5 trocars, parenchymal dissection was performed with ultrasonic shears (Harmonic Ace ® ; Ethicon Endo-Surgery, Cincinnati, OH, USA) and, for larger/posterior lesions or resections, laparoscopic cavitron ultrasonic surgical aspirator (CUSA) (Valleylab, Boulder, CO, USA). For left lateral sectionectomy, only ultrasonic shears and endostaplers were used. Rarely, for posterior lesions, a handport was used (n = 4). Specimens were extracted in a plastic endoscopic bag (Endocatch; Ethicon Endo-Surgery, Cincinnati, OH, USA) via a Pfannenstiel incision or, in case of lesions <3 cm, through a widened trocar incision. Pringle maneuver was applied for laparoscopic major procedures, including posterior metastasectomies and larger, atypical metastasectomies. For metastasectomies the 'diamond technique' was preferred. 19 All laparoscopic hemihepatectomies and laparoscopic resections involving segment 7 were performed by a team of two surgeons (MB, PT).
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