High performance digital ft nmr spectrometer advance 3

Melting points were determined by open glass capillary tubes using an Electro thermal IA9100 digital melting point apparatus and were uncorrected. Elemental microanalyses were carried out at the Micro Analytical Unit at Cairo University and were found within ± 0.5%. ¹H NMR and ¹³C NMR spectra were recorded on a Bruker High Performance Digital FT-NMR Spectrometer Advance III (400/100 MHz) in the presence of TMS as the internal standard. Infrared spectra were recorded by using the KBr disc technique on a Jasco FT/IR-6100, Fourier transform, Infrared spectrometer (Japan) at the cm⁻¹ scale. The ESI-mass spectra were measured using an Advion Compact Mass Spectrometer (CMS) NY, USA. Follow-up of the reactions and checking the purity of the compounds were made by TLC on silica gel aluminum sheets (Type 60, F 254, Merck, Darmstadt, Germany) and the spots were illustrated by exposure to UV analysis lamp at λ 254/366 nm or by iodine vapor. The nomenclature of the new synthesized compounds is according to the IUPAC system. The starting 3-amino-6-phenylthieno[2,3-b]pyridine-2-carboxamides 1a,b were prepared as per reported methods [44 ,45 ].

The melting points were obtained in open capillary tubes using an Electrothermal IA9100 digital melting point apparatus. Elemental microanalyses were carried out at the Micro Analytical Unit at Cairo University. ¹H NMR and ¹³C NMR spectra were recorded on a Bruker High Performance Digital FT-NMR Spectrometer Advance III (400/100 MHz) in the presence of TMS as the internal standard at Ain Shams University, Cairo, Egypt. Infrared spectra were measured using the KBr disc technique on a Jasco FT/IR-6100 Fourier transform IR spectrometer (Japan) at the scale of 400–4000 cm⁻¹. ESI-mass spectra were determined using an Advion Compact Mass Spectrometer (CMS), NY, USA. TLC on silica gel-precoated aluminum sheets (Type 60, F 254, Merck, Darmstadt, Germany) was used for following up the reactions and checking the purity of the chemical compounds using chloroform/methanol (3:1, v/v), and spots were detected with iodine vapor or through exposure to a UV lamp at δ 254 nm for several seconds. The nomenclature of the compounds is according to the IUPAC system. The starting compounds, 3-amino-thieno[2,3-b]pyridine-2-carboxamides (1a,b), were prepared using the reported method [56 (link)].