Dexketoprofen ((R, S)-2-(3-benzoylphenyl)propionic acid) with purity of 99.5% was purchased from Huangshi Shixing Pharmaceuticals Co. Ltd. (Huangshi, China). Fenli was purchased from Hubei Anlian Pharmaceutical Co. Ltd. (Wuxue, China). Azone (AZO), isopropyl myristate (IPM), propylene glycol (PG), lauryl lactate (LA), and poly(ethylene glycol) (PEG) 200 were purchased from Merck Chemicals Co. Ltd. (Shanghai, China). Eudragit RL PO was provided by Degussa (Germany). Plasdone S-630 was supplied by International Specialty Products (USA). Kollidone PF 12 and PVP K30 were procured from BASF (Germany). Egg-albumin, xylene, and L-arginine were purchased from Aladdin Industrial Co. (Shanghai, China). Acetic acid was procured from Sino Pharm Chemicals Co. Ltd. (Shanghai, China). All other chemicals and solvents were of analytical reagent grade or chromatography reagent grades.
All the animals used in this study were purchased from the SLAC Laboratory Animal Company Ltd. (Shanghai, China). The animal studies in this study were performed in accordance with the Ethical Guidelines for Investigations in Laboratory Animals and was approved by the National Pharmaceutical Engineering and Research Center.
All the animals used in this study were purchased from the SLAC Laboratory Animal Company Ltd. (Shanghai, China). The animal studies in this study were performed in accordance with the Ethical Guidelines for Investigations in Laboratory Animals and was approved by the National Pharmaceutical Engineering and Research Center.