Skyra 3.0t scanner

Manufactured by Siemens

Sourced in Germany

The Skyra 3.0T scanner is a magnetic resonance imaging (MRI) device manufactured by Siemens. It operates at a magnetic field strength of 3.0 Tesla and is designed to produce high-quality images of the human body for clinical and research applications.

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Lab products found in correlation

20 channel radio frequency head coil, by Siemens (1 mentions) Discovery mr750 3.0t scanner, by GE Healthcare (1 mentions) Discovery mr750w 3.0t scanner, by GE Healthcare (1 mentions) Discovery 750, by GE Healthcare (1 mentions) 32 channel head coil, by Siemens (1 mentions) 8 channel head coil, by Siemens (1 mentions)

Close spelling variants of this product

Skyra 3.0T 3.0T scanners Skyra scanner Siemens scanners

9 protocols using skyra 3.0t scanner

Neuroimaging Protocol for Functional MRI

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All MRI data was acquired on a Siemens Skyra 3.0T scanner equipped with a standard 20-channel radio-frequency head coil. Thirty-two slices were obtained in an oblique orientation of 30° to the anterior commissure-posterior commissure line to prevent signal drop-out from the prefrontal cortex (27 (link)).
High-resolution structural images were collected using a standard T1-weighted pulse sequence (TR = 2,100 ms, TE = 3.43 ms; 32 slices; 1 × 1 × 1 mm voxels). Using these images, functional activation could be localized. Functional data for four runs, consisting of 172 volumes each, was collected by using a standard T2^*-weighted echo planar sequence (TR = 2,000 ms; TE = 30 ms; 3 × 3 × 3 mm voxels; flip angle = 90°; FoV = 256 mm; slice gap = 1 mm) sensitive to the blood oxygen level dependent (BOLD) contrast.

Spirou A., Liu P.P., Natsheh J.Y., Neuteboom E, & Dobryakova E. (2018). Neural Correlates of Outcome Anticipation in Multiple Sclerosis. Frontiers in Neurology, 9, 572.

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MRI Protocols for Neoadjuvant Chemoradiotherapy

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Patients received baseline MR scan in 2 weeks before nCRT. Fat-suppressed T2WI were accessed from two institutions. At institution 1, all MR examinations were performed using a GE Discovery MR750w 3.0T scanner or a GE Discovery MR750 3.0T scanner. At institution 2, MR examinations were performed using four scanners (SIEMENS Skyra 3.0T scanner, SIEMENS Avanto 1.5T scanner, UIH uMR780 3.0T scanner, and UIH uMR588 1.5T scanner). Details of all scanner protocols are provided in eTable 1.

Liu Y., Wang Y., Wang X., Xue L., Zhang H., Ma Z., Deng H., Yang Z., Sun X., Men Y., Ye F., Men K., Qin J., Bi N., Wang Q, & Hui Z. (2024). MR radiomics predicts pathological complete response of esophageal squamous cell carcinoma after neoadjuvant chemoradiotherapy: a multicenter study. Cancer Imaging, 24, 16.

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Functional MRI Preprocessing Pipeline

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All participants in the discovery cohort underwent MRI image scanning using a 3.0T scanner (Discovery 750; GE Healthcare, USA). The MRI data of participants in the validation cohort were collected using a Siemens Skyra 3.0T scanner (Siemens Medical, Erlangen, Germany). Detailed scan sequences and parameters are described in the Data S1 (Method 2). Functional images were preprocessed using DPARSF (v5.2, http://rfmri.org/dparsf) and SPM12 toolbox (http://www.fil.ion.ucl.ac.uk/spm). Slice timing correction and head motion correction were conducted after removing the first 15 time points. Participants with excessive head motion (2 mm translation or 2.0° rotation) were excluded. Structural images were co‐registered to the preprocessed functional images, and then segmented into GM, WM, and cerebrospinal fluid (CSF) by using DARTEL. The resulting images were normalized to the Montreal Neurological Institute space, and each voxel was resampled to 3 × 3 × 3 mm³. Next, the mean signals from CSF, Friston‐24 head motion parameters were regressed out by multiple linear regression analysis. To avoid elimination of important neural signals, we did not remove WM and brain global signal. Finally, smoothing with 6 mm full‐width half‐maximum, detrending, and temporal filtering (bandpass, 0.01–0.08 Hz) were performed.

Gai Q., Chu T., Li Q., Guo Y., Ma H., Shi Y., Che K., Zhao F., Dong F., Li Y., Xie H, & Mao N. (2024). Altered intersubject functional variability of brain white‐matter in major depressive disorder and its association with gene expression profiles. Human Brain Mapping, 45(5), e26670.

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Multimodal MRI Acquisition and Preprocessing

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Procedures for image acquisition and pre-processing have been performed by UK Biobank, and are available on the UK Biobank website (http://www.ukbiobank.ac.uk/), and have been documented previously33 37 (link). In short, images were collected in Cheadle Manchester on a Siemens Skyra 3.0 T scanner (Siemens Medical Solutions, Germany) with a 32-channel head coil (https://www.healthcare.siemens.com/magnetic-resonance-imaging). T1-weighted scans were acquired using a 3D MPRAGE (resolution 1 mm³ isotropic voxels) sequence, and diffusion-weighted (DW) scans were acquired with a monopolar Steejskal-Tanner pulse sequence and multi-shell acquisition (b₀ = 0 s/mm², b = 1,000 s/mm², b = 2,000 s/mm²). Images were preprocessed and analysed with the FMRIB Software Library (FSL) (http://fsl.fmrib.ox.ac.uk/fsl). More detailed information is reported in the supplementary materials.

Reus L.M., Shen X., Gibson J., Wigmore E., Ligthart L., Adams M.J., Davies G., Cox S.R., Hagenaars S.P., Bastin M.E., Deary I.J., Whalley H.C, & McIntosh A.M. (2017). Association of polygenic risk for major psychiatric illness with subcortical volumes and white matter integrity in UK Biobank. Scientific Reports, 7, 42140.

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Functional MRI Protocol for Brain Imaging

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All scans were acquired using a Siemens Skyra 3.0 T scanner at the Lewis Center for Neuroimaging at the University of Oregon. Participants completed a mock scan prior to the MRI scan to familiarize them with the scanner. They received instructions for the task and practiced the task during the mock scan. Acquisition parameters were as follows: 2 × 180 volumes of 72 slices with 2 mm isometric voxels, TR = 2000 ms, TE = 25 ms, multiband acceleration factor = 3, in plane acceleration factor = 2, FOV = 208 mm, flip angle = 90°, duration = 6.5 min. per run. T1-weighted images were acquired as follows for co-registration: sagittal 3D MP-RAGE, 176 slices with 1 mm isometric voxels, FOV = 256 mm, TR = 2500 ms, TE = 3.41 ms, flip angle = 7°, TI = 1100 ms, matrix size = 256 × 256, acceleration factor = 2.

Barendse M.E., Cosme D., Flournoy J.C., Vijayakumar N., Cheng T.W., Allen N.B, & Pfeifer J.H. (2020). Neural correlates of self-evaluation in relation to age and pubertal development in early adolescent girls. Developmental Cognitive Neuroscience, 44, 100799.

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MRI Brain Image Processing Pipeline

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Image acquisition and pre-processing of MRI scans have been performed by UK Biobank. Brain images were acquired on a Siemens Skyra 3.0 T scanner (Siemens Medical Solutions, Germany) with a 32-channel head coil. T1-weighted images with 1 mm³ isotropic resolution were previously analysed with FMRIB Software Library (FSL) (http://fsl.fmrib.ox.ac.uk/fsl), with image-derived phenotypes (IDPs – imaging summary statistics such as brain volume and hippocampal volume) made available for general access. More detailed information on MRI acquisition and analysis have been reported elsewhere (Miller et al., 2016 (link); Alfaro-Almagro et al., 2018 (link)). UK Biobank also published a standardised MRI analysis pipeline (FMRIB's Biobank Pipeline version 1.0) that is freely available to the public, including the source code (https://git.fmrib.ox.ac.uk/falmagro/UK_biobank_pipeline_v_1) (Alfaro-Almagro et al., 2018 (link)).

Nobis L., Manohar S.G., Smith S.M., Alfaro-Almagro F., Jenkinson M., Mackay C.E, & Husain M. (2019). Hippocampal volume across age: Nomograms derived from over 19,700 people in UK Biobank. NeuroImage : Clinical, 23, 101904.

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High-Resolution T1-Weighted Structural MRI Acquisition

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Magnetic resonance imaging scanning was performed on a Siemens Skyra 3.0T scanner with an 8-channel head coil in the Shenzhen Sixth Hospital of Guangdong Medical University. All subjects were instructed to remain still and awake with their eyes closed during scanning. High-resolution T1-weighted structural images were obtained using a Siemens 3D MPRAGE sequence with the following parameters: 320 slices, slice thickness = 0.6 mm, TR/TE = 1900/2.12 ms, field of view = 256 × 256 mm², data matrix = 448 × 448, spatial resolution = 0.57 × 0.57 × 0.60 mm³, inversion time = 900 ms, flipped angle = 9°.

Zeng P., Huang J., Wu S., Qian C., Chen F., Sun W., Tao W., Liao Y., Zhang J., Yang Z., Zhong S., Zhang Z., Xiao L, & Huang B. (2019). Characterizing the Structural Pattern Predicting Medication Response in Herpes Zoster Patients Using Multivoxel Pattern Analysis. Frontiers in Neuroscience, 13, 534.

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Multi-Sequence MRI Imaging Protocol

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Patients from training set and test set 1 were examined on scanner A (Siemens Magnetom Essenza 1.5-T scanner), and patients from test set 2 were examined on scanner B and C (GE Signa HDxt 3.0-T scanner, Siemens Magnetom Skyra 3.0-T scanner). Axial and coronal fast-spin-echo (FSE) T1-weighted image (T1WI), fat-suppressed T2-weighted image (T2WI) and contrast-enhanced T1-weighted image (CE-T1WI) were performed on all patients. Gadopentetate dimeglumine (Gd⁃DTPA) contrast agent was administered intravenously at an injection dose of 0.1 mL/kg body weight and rate of 2.5mL/sec. The scanning protocol and parameters are detailed in the Supplementary Table S1.

Gu J., Yu Q., Li Q., Peng J., Lv F., Gong B, & Zhang X. (2022). MRI radiomics-based machine learning model integrated with clinic-radiological features for preoperative differentiation of sinonasal inverted papilloma and malignant sinonasal tumors. Frontiers in Oncology, 12, 1003639.

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Non-Invasive Renal Imaging Protocol

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Subjects were instructed not to drink water 1 hour before the examination. If they could not cooperate with the examination, a 6.5% chloral hydrate (0.8 mL/kg) solution was taken orally for sedation. Subjects who were able to cooperate with the examination in the awake state underwent prior breathing training. The MRI was performed with a Siemens Skyra 3.0T scanner (Siemens Healthcare, Erlangen, Germany). Subjects were laid in the supine position, and their body surface was covered with an 18-channel body coil with the renal region as the center. The scanning sequence included coronal T2-weighted imaging (T2WI), axial T1-weighted imaging (T1WI), fat-suppressed T2WI, IVIM, and DKI. Simultaneous multi-slice (SMS) was used to complete the IVIM and DKI sequences in one scan and combined with a single shot-echo planar imaging (SS-EPI) sequence with multi-b values (0, 10, 20, 30, 50, 100, 200, 300, 500, 800, 1,000, 1,500, and 2,000 s/mm²) for coronal scanning with the level of the renal hilum as the center (5 (link)).

Yan Z., Chen L., Shen W., Dong L., Wang C., Guan Y., Zheng M., Li Y., Zhang C, & Grimm R. (2022). Preliminary study on intravoxel incoherent motion imaging and diffusion kurtosis imaging based on magnetic resonance imaging of normal kidneys in children. Translational Pediatrics, 11(12), 1928-1938.

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