Ferroptosis inducer, RSL3 and erastin, and ferroptosis inhibitor, ferrostatin-1 (Fer-1), were purchased from selleckchem. Ferroptosis inducer, FIN56, was purchased from MedChemExpress. Other reagents used in this article: CAY10566, Z-VAD-FMK, oleic acid, palmitoleic acid, DIM-C-pPhOH, gemcitabine were purchased from MedChemExpress.
Cay10566
Manufactured by MedChemExpress
CAY10566 is a laboratory reagent product offered by MedChemExpress. It functions as an inhibitor of the enzyme DNA methyltransferase 1 (DNMT1). The core purpose of this product is to serve as a research tool to study the role of DNMT1 in biological processes.
Automatically generated - may contain errors
Lab products found in correlation
Fin56, by MedChemExpress (1 mentions)
Dim c pphoh, by MedChemExpress (1 mentions)
Oleic acid, by MedChemExpress (1 mentions)
Ferrostatin 1, by Selleck Chemicals (1 mentions)
Erastin, by Selleck Chemicals (1 mentions)
Z vad fmk, by MedChemExpress (1 mentions)
Gemcitabine, by MedChemExpress (1 mentions)
Tunicamycin, by Merck Group (1 mentions)
Thapsigargin, by Merck Group (1 mentions)
Atglistatin, by Merck Group (1 mentions)
Gsk2850163, by Merck Group (1 mentions)
Ceapin a7, by Merck Group (1 mentions)
Gsk2606414, by MedChemExpress (1 mentions)
Bafilomycin a1, by Avantor (1 mentions)
2 protocols using cay10566
1
Ferroptosis Inducers and Inhibitors
2
Modulation of Lipid Metabolism Pathways
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TAG formation was inhibited using the DGAT1 inhibitor T863 (MedChemExpress, #HY-32219) and the DGAT2 inhibitor PF 06424439 (Bio-Techne, #6348/5). Import of fatty acids into mitochondria was blocked by CPT1 inhibitor etomoxir (Calbiochem, #236020). Desaturation of fatty acids was inhibited by the SCD1 inhibitor CAY10566 (MedChemExpress, #HY-15823-1mg). Lipolysis was inhibited by treating the cells with the ATGL inhibitor atglistatin (Sigma-Aldrich, #SML1075). The ER stress response branches were inhibited individually using the PERK inhibitor GSK2606414 (MedChemExpress, #HY-18072), the IRE1a inhibitor GSK2850163 (Sigma-Aldrich, #1684), and the ATF6 inhibitor Ceapin-A7 (Sigma-Aldrich, #SML2330). ER stress was chemically induced with tunicamycin (Sigma-Aldrich, #5045700001) and thapsigargin (Sigma-Aldrich, #586005). Autophagosome-lysosome fusion was blocked using the V-ATPase inhibitor bafilomycin A1 (VWR, #J61835.MX). The concentration of each treatment is indicated in the figure legends.
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