Magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) were performed to evaluate local inflammation within the lesion site and regeneration of tracking fibers using the Discovery 750 system (3.0 Tesla, GE Medical Systems, Waukesha, WI, USA). Rats from the different treatment groups were imaged before and at 30 days after intrathecal transplantation (n = 3/group). Rats euthanatized with an intraperitoneal administration of 1% pentobarbital sodium (50 mg/kg) were fastened to the center of the small-animal special coil (Wankang, Jiangyin, Jiangsu, China) and placed on the scanning bed. T2-weighted and DTI images of the SCI site (T7–T12) were then obtained. The parameters for the T2-weighted scans were time of repetition = 3000 ms, matrix = 192 × 192, field of view (FOV) = 100 mm, thickness = 1 mm, spacing = 0 mm, and number of excitations = 8. The parameters for the DTI scans were time of echo = 66.6 ms, time of repetition = 3200 ms, bandwidth = 166.7 kHz, matrix = 96 × 48, FOV = 80 mm, phase FOV = 0.5, thickness = 2 mm, spacing = 0 mm, number of excitations = 10, b (dispersion sensitivity) = 800, and the number of diffusion directions = 9. Image post-processing software (Functool) in the AW 4.6 workstation (GE Healthcare, Chicago, IL, USA) was used to reconstruct MRI T2-weighted and DTI images in both anterior-posterior and sagittal views.
Discovery 750 system
Manufactured by GE Healthcare
Sourced in United States
The Discovery 750 system is a medical imaging device designed for Positron Emission Tomography (PET) and Computed Tomography (CT) imaging. It provides integrated PET and CT capabilities for diagnostic and research applications.
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3 protocols using discovery 750 system
1
MRI and DTI Evaluation of SCI Lesions
2
Resting-State fMRI Acquisition Protocol
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MR data acquisition was conducted on a 3-T GE MR scanner (Discovery 750 System, Milwaukee, WI, USA) with a 16-channel head coil. The rs-fMRI data were obtained using the following parameters: 32 axial slices without slice gap, repetition time (TR)/echo time = 2,000/41 ms, field of view = 220 × 220 mm2, in-plane matrix = 64 × 64, section thickness = 5 mm, slice gap = 0.4 mm, flip angle = 90°, and a total of 240 volumes and lasted 480 s for each subject. All participants were placed in a supine position with wearing earplugs to reduce the noise. To reduce head excessive motion, a foam pad was fixed on the both sides of head. During MR scanning, all participants were required to keep their eyes closed and heads still without falling asleep and try not to think about anything in particular.
3
Resting-state fMRI Acquisition Protocol
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All the MR scans were performed on a 3.0‐T MR scanner (Discovery 750 system; GE Healthcare, Waukesha, WI) with a 16‐channel head coil. Subjects were placed in a supine position with a foam pad fixed on the head to reduce head motion during MR scanning. At the same time, rubber earplugs were used to minimize the discomfort that the noise caused to the subjects. During MR scanning, all subjects were told to be quiet, keep their eyes closed and heads still, but stay awake, and try not to think about anything. The Rs‐fMRI data were obtained using a gradient‐echo echo‐planar (GRE‐EPI) sequence with the following parameters: 32 axial slices; repetition time/echo time, 2000/41 ms; field of view, 220 × 220 mm2; matrix, 64 × 64; section thickness, 5 mm; slice gap, 0.4 mm; flip angle, 90°. Each functional scan included 240 brain volumes and lasted 480 s. High‐resolution three‐dimensional T1‐weighted anatomical images were acquired using a three‐dimensional brain volume imaging (3D‐BRAVO) sequence (188 sagittal slices, 1‐mm in‐plane resolution).
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